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significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
challenges decrease » challenges case (Expand Search)
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1101
Table 2_Long-term trends and comparison of the burden of lower respiratory tract infections in China and globally from 1990 to 2021: an analysis based on the Global Burden of Disea...
Published 2024“…Compared with the previous period, the COVID-19 pandemic has led to a significant decrease in the disease burden of LRIs. …”
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1102
Data Sheet 1_Understanding mechanistic relationships between IgG titers and Fc effector functions: a computational framework to assess polyfunctionality.docx
Published 2025“…Surprisingly, simulated boosting of IgG3 alone had the potential to significantly decrease ADCP (p<0.00001), though it would increase ADCC responses. …”
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1103
Data Sheet 1_Comparison of trend analysis of varicella zoster disease burden between China and the world 1990–2021 and disease burden forecast 2030.csv
Published 2025“…Projections suggest a slight decrease in the VZV burden in China by 2030. However, due to the country’s large and aging population, VZV will continue to pose a significant public health challenge.…”
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1104
Table 1_The burden and etiologies of diarrhea in Asia and its countries from 1990 to 2021 and the forecast to 2040: analyses informed by the global burden of disease study 2021.doc...
Published 2025“…</p>Conclusion<p>The study demonstrates an overall declining trend in the burden of diarrhea in Asia due to urbanization, economic growth, and public health interventions. However, significant challenges persist in some countries and specific population groups. …”
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1105
Data Sheet 1_Emotional prompting amplifies disinformation generation in AI large language models.docx
Published 2025“…The widespread dissemination of AI-generated disinformation adds complexity to the existing challenges of the ongoing infodemic, significantly affecting public health and the stability of democratic institutions.…”
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1106
Table 5_The burden and etiologies of diarrhea in Asia and its countries from 1990 to 2021 and the forecast to 2040: analyses informed by the global burden of disease study 2021.doc...
Published 2025“…</p>Conclusion<p>The study demonstrates an overall declining trend in the burden of diarrhea in Asia due to urbanization, economic growth, and public health interventions. However, significant challenges persist in some countries and specific population groups. …”
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1107
Table 2_The burden and etiologies of diarrhea in Asia and its countries from 1990 to 2021 and the forecast to 2040: analyses informed by the global burden of disease study 2021.doc...
Published 2025“…</p>Conclusion<p>The study demonstrates an overall declining trend in the burden of diarrhea in Asia due to urbanization, economic growth, and public health interventions. However, significant challenges persist in some countries and specific population groups. …”
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1108
Data Sheet 1_The burden and etiologies of diarrhea in Asia and its countries from 1990 to 2021 and the forecast to 2040: analyses informed by the global burden of disease study 202...
Published 2025“…</p>Conclusion<p>The study demonstrates an overall declining trend in the burden of diarrhea in Asia due to urbanization, economic growth, and public health interventions. However, significant challenges persist in some countries and specific population groups. …”
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1109
Table 4_The burden and etiologies of diarrhea in Asia and its countries from 1990 to 2021 and the forecast to 2040: analyses informed by the global burden of disease study 2021.doc...
Published 2025“…</p>Conclusion<p>The study demonstrates an overall declining trend in the burden of diarrhea in Asia due to urbanization, economic growth, and public health interventions. However, significant challenges persist in some countries and specific population groups. …”
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1110
Table 3_The burden and etiologies of diarrhea in Asia and its countries from 1990 to 2021 and the forecast to 2040: analyses informed by the global burden of disease study 2021.doc...
Published 2025“…</p>Conclusion<p>The study demonstrates an overall declining trend in the burden of diarrhea in Asia due to urbanization, economic growth, and public health interventions. However, significant challenges persist in some countries and specific population groups. …”
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1111
Icaritin and lenvatinib treatment for unresectable localized progressive pancreatic cancer: a report of six cases
Published 2025“…Cases 4 and 5 showed limited relief following a slight decrease in tumor size. In cases 2 and 6, no significant progression of the lesion was observed. …”
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1112
Supplementary Material for: Immune Synaptopathy and Sex Differences in Recognition Memory from Neonatal Staphylococcus epidermidis Infection
Published 2025“…At the cellular level, both sexes displayed a significant decrease in doublecortin-positive (DCX⁺) neurons in the dentate gyrus after SE infection, indicating impaired neuroplasticity. …”
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1113
Table1_Identification of key biomarkers and therapeutic targets in sepsis through coagulation-related gene expression and immune pathway analysis.docx
Published 2024“…<p>Sepsis, characterized by a widespread and dysregulated immune response to infection leading to organ dysfunction, presents significant challenges in diagnosis and treatment. In this study, we investigated 203 coagulation-related genes in sepsis patients to explore their roles in the disease. …”
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1114
Data Sheet 1_Effects of cattle manure and sludge vermicompost on nutrient dynamics and yield in strawberry cultivation with distinct continuous cropping histories in a greenhouse.d...
Published 2025“…<p>Continuous cropping has emerged as a significant challenge affecting yield and quality in greenhouse strawberries, particularly as the cultivation of strawberries as a protected crop continues to increase. …”
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1115
Image 5_Trends and cross-country inequality in the global burden of nutritional deficiencies in children, with projections to 2035: results from the Global Burden of Disease study...
Published 2025“…Background<p>Nutritional deficiencies in children are a significant global health concern, contributing to considerable morbidity and mortality. …”
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1116
Image 8_Trends and cross-country inequality in the global burden of nutritional deficiencies in children, with projections to 2035: results from the Global Burden of Disease study...
Published 2025“…Background<p>Nutritional deficiencies in children are a significant global health concern, contributing to considerable morbidity and mortality. …”
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1117
Image 7_Trends and cross-country inequality in the global burden of nutritional deficiencies in children, with projections to 2035: results from the Global Burden of Disease study...
Published 2025“…Background<p>Nutritional deficiencies in children are a significant global health concern, contributing to considerable morbidity and mortality. …”
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1118
Image 6_Trends and cross-country inequality in the global burden of nutritional deficiencies in children, with projections to 2035: results from the Global Burden of Disease study...
Published 2025“…Background<p>Nutritional deficiencies in children are a significant global health concern, contributing to considerable morbidity and mortality. …”
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1119
Table 4_Trends and cross-country inequality in the global burden of nutritional deficiencies in children, with projections to 2035: results from the Global Burden of Disease study...
Published 2025“…Background<p>Nutritional deficiencies in children are a significant global health concern, contributing to considerable morbidity and mortality. …”
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1120
Image 2_Trends and cross-country inequality in the global burden of nutritional deficiencies in children, with projections to 2035: results from the Global Burden of Disease study...
Published 2025“…Background<p>Nutritional deficiencies in children are a significant global health concern, contributing to considerable morbidity and mortality. …”