Search alternatives:
significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
challenges decrease » challenges case (Expand Search)
significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
challenges decrease » challenges case (Expand Search)
-
1321
Image 2_Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway.jpeg
Published 2024“…MiR-936 overexpression and GV102-Pim-3-shRNA significantly attenuated the activity of the ANKRD18A/Src/NRF2 pathway to decrease the expression of Ankyrin repeat domain-containing protein 18A (ANKRD18A), Src, and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), especially decreasing NRF2 nuclear retention and transcriptional activity. …”
-
1322
Image 1_Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway.jpeg
Published 2024“…MiR-936 overexpression and GV102-Pim-3-shRNA significantly attenuated the activity of the ANKRD18A/Src/NRF2 pathway to decrease the expression of Ankyrin repeat domain-containing protein 18A (ANKRD18A), Src, and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), especially decreasing NRF2 nuclear retention and transcriptional activity. …”
-
1323
Image 5_Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway.jpeg
Published 2024“…MiR-936 overexpression and GV102-Pim-3-shRNA significantly attenuated the activity of the ANKRD18A/Src/NRF2 pathway to decrease the expression of Ankyrin repeat domain-containing protein 18A (ANKRD18A), Src, and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), especially decreasing NRF2 nuclear retention and transcriptional activity. …”
-
1324
Table 1_Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway.docx
Published 2024“…MiR-936 overexpression and GV102-Pim-3-shRNA significantly attenuated the activity of the ANKRD18A/Src/NRF2 pathway to decrease the expression of Ankyrin repeat domain-containing protein 18A (ANKRD18A), Src, and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), especially decreasing NRF2 nuclear retention and transcriptional activity. …”
-
1325
Image 3_Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway.jpeg
Published 2024“…MiR-936 overexpression and GV102-Pim-3-shRNA significantly attenuated the activity of the ANKRD18A/Src/NRF2 pathway to decrease the expression of Ankyrin repeat domain-containing protein 18A (ANKRD18A), Src, and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), especially decreasing NRF2 nuclear retention and transcriptional activity. …”
-
1326
Table 1_Analysis of the threshold range of ROS concentration in winter rapeseed of the Brassica napus type.docx
Published 2025“…<p>The threshold range of reactive oxygen species (ROS) concentration remains a critical challenge and focal point in future research concerning its influence on the growth and development of both beneficial and harmful plants. …”
-
1327
Image1_The fruit fly Drosophila melanogaster as a screening model for antiseizure medications.JPEG
Published 2024“…Despite numerous newly marketed ASMs, the proportion of drug-resistant people with epilepsy has not significantly decreased over the years. Therefore, novel and innovative seizure models for preclinical drug screening are highly desirable. …”
-
1328
Data_Sheet_1_Investigating the impact of mental rehearsal on prefrontal and motor cortical haemodynamic responses in surgeons using optical neuroimaging.docx
Published 2024“…Mean objective performance score was significantly higher following MR compared with TR (p = 0.043).…”
-
1329
Table 1_Comparative study of endophytic bacterial strains from non-host crops for enhancing plant growth and managing early blight in tomato.docx
Published 2024“…In the glasshouse, individual and combined applications via seed treatment (ST), seedling dip (SD), and foliar spray (FS) significantly enhanced shoot growth (23.63–57.61%), root growth (43.27–118.23%), number of leaves (77.52–93.58%), number of shoots (33.42–45.28%) and root dry matter (42.17–43.86%), reducing early blight (PDI) by 70.95–76.12% compared to uninoculated control. …”
-
1330
Supplementary file 1_Characterizing rainfall patterns and dynamics in the Little Ruaha catchment, southern Tanzania.docx
Published 2025“…<p>Water resources in many regions are increasingly under pressure due to population growth, agricultural expansion, and climate variability, which presents significant challenges in maintaining sustainable water supplies. …”
-
1331
Supplementary file 1_MoodyTunes: a single cohort study of a music-based smartphone app for mental health and mood regulation in young people.pdf
Published 2025“…Depression was found to have decreased, although not at a statistically significant level. …”
-
1332
Supporting data for "The Mediating and Moderating Factors in the Association between Tooth Loss and Cognitive Decline"
Published 2025“…The management and financial burden of AD, including the support required for affected patients, pose significant challenges to individuals, families, and the healthcare system.…”
-
1333
Data Sheet 1_A standard procedure for dune mapping along the Bulgarian Black Sea coast: an integrated approach combining UAS photogrammetry, geomorphological and phytocoenological...
Published 2025“…The urbanization of coastal areas, global warming and rising sea levels pose significant threats to CD systems, leading to erosion and habitat loss. …”
-
1334
Data Sheet 2_Forecasting the production and export of shrimp in Bangladesh: a policy focused time series analysis.docx
Published 2025“…The VAR(1) model predicts a slight decline in production by 2026–27, with exports potentially decreasing by a factor of 3.2 compared to 2010–11. Key challenges include hazardous residues, poor management practices, and disease outbreaks. …”
-
1335
Data Sheet 1_Forecasting the production and export of shrimp in Bangladesh: a policy focused time series analysis.docx
Published 2025“…The VAR(1) model predicts a slight decline in production by 2026–27, with exports potentially decreasing by a factor of 3.2 compared to 2010–11. Key challenges include hazardous residues, poor management practices, and disease outbreaks. …”
-
1336
多杀性巴氏杆菌流行过程中水平基因转移对其毒力与耐药的影响-附录.xlsx
Published 2024“…The transcription levels of iron acquisition systems such as fecABCDE, sitABCD operons, and dppAB were also significantly reduced, but the afuAB-dependent periplasmic binding protein-mediated iron transport mechanism was significantly upregulated. …”
-
1337
Potential benefits and neural correlates of adjunctive acupuncture therapyin unilateral stroke rehabilitation
Published 2024“…Previous studies have shown it to improve balance, decrease spasticity, increase muscle strength, and enhance mean blood-flow velocity in the brains of stroke patients. …”
-
1338
Table 1_Telestroke management during the Hajj seasons 2023–2024: insights from SEHA Virtual Hospital in KSA.xlsx
Published 2025“…Background<p>The Hajj pilgrimage in Saudi Arabia poses significant healthcare challenges due to overcrowding and high demand. …”
-
1339
Table_1_Toward workforce integration: enhancements in adaptive behaviors and social communication skills among autistic young adults following vocational training course.DOCX
Published 2024“…No significant Time x Group interaction was found for any of the examined measures, meaning similar trends were observed in all three vocational groups.…”
-
1340
Data Sheet 1_Evaluation of tolerability and safety of transcranial electrical stimulation with gel particle electrodes in healthy subjects.pdf
Published 2024“…Additionally, fatigue increased, and energy levels decreased on VAMS-R with longer durations. No significant differences were found in other neuropsychological tests.…”