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significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
challenges decrease » challenges case (Expand Search)
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1441
Image 2_Phage (cocktail)-antibiotic synergism: a new frontier in addressing Klebsiella pneumoniae resistance.tif
Published 2025“…In vitro investigations demonstrated that the phage cocktail significantly decreased both planktonic and sessile cells. …”
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1442
Table 4_Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden...
Published 2025“…Introduction<p>Congenital heart disease (CHD) represents a significant global public health burden, with substantial variability in mortality rates across different regions and age groups.…”
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1443
Table 3_Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden...
Published 2025“…Introduction<p>Congenital heart disease (CHD) represents a significant global public health burden, with substantial variability in mortality rates across different regions and age groups.…”
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1444
<b>Evaluating Trauma-Focused Cognitive Behavioral Therapy in Earthquake Survivors: A Controlled Trial</b>
Published 2024“…<p dir="ltr">Traumatic events such as earthquakes often lead to significant psychological distress among survivors. …”
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1445
Table 1_Phage (cocktail)-antibiotic synergism: a new frontier in addressing Klebsiella pneumoniae resistance.xls
Published 2025“…In vitro investigations demonstrated that the phage cocktail significantly decreased both planktonic and sessile cells. …”
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1446
Image 2_Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden...
Published 2025“…Introduction<p>Congenital heart disease (CHD) represents a significant global public health burden, with substantial variability in mortality rates across different regions and age groups.…”
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1447
Image 4_Phage (cocktail)-antibiotic synergism: a new frontier in addressing Klebsiella pneumoniae resistance.tif
Published 2025“…In vitro investigations demonstrated that the phage cocktail significantly decreased both planktonic and sessile cells. …”
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1448
DataSheet2_Diverse responses of hypoxia-inducible factor alpha mRNA abundance in fish exposed to low oxygen: the importance of reporting methods.CSV
Published 2024“…<p>Low dissolved oxygen (hypoxia) poses significant challenges to aquatic ecosystems, affecting the behavior, reproduction, and survival of aquatic organisms. …”
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1449
Effects of efgartigimod treatment on humoral and cellular immune responses: analysis of T-cell-dependent antibody response in cynomolgus monkeys
Published 2025“…No statistically significant differences emerged in anti-KLH IgM levels between the efgartigimod and control groups. …”
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1450
DataSheet1_Anaerobic membrane bioreactor (AnMBR) with external ultrafiltration membrane for the treatment of sugar beet vinasse.PDF
Published 2024“…<p>Vinasse, a by-product of ethanol production, is generated at significant rates. While rich in nutrients such as calcium, magnesium, and potassium, its high solids, organic matter, acidity, and sulfate content pose challenges when disposed directly on soil, necessitating treatment. …”
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1451
Data Sheet 1_Plant and soil microbial composition legacies following indaziflam herbicide treatment.pdf
Published 2024“…Indaziflam application also was associated with increased soil nitrate (NO<sub>3</sub><sup>−</sup>), decreased soil organic matter, and had a significant effect on the composition of the soil microbiome. …”
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1452
Supplementary file 1_Age-period-cohort analysis of syphilis epidemics in Eastern China, China, 2005–2024.docx
Published 2025“…The reported incidence of syphilis decreased by an average of −3.53% per year across all age groups (95% CI: −4.34, −2.70%). …”
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1453
Image 1_Age-period-cohort analysis of syphilis epidemics in Eastern China, China, 2005–2024.jpeg
Published 2025“…The reported incidence of syphilis decreased by an average of −3.53% per year across all age groups (95% CI: −4.34, −2.70%). …”
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1454
Data Sheet 1_Immune monitoring of trabectedin therapy in refractory soft tissue sarcoma patients - the IMMUNYON study.pdf
Published 2025“…Gene expression analysis identified changes in BTRC (decreased), IFNA1 (increased), and IL9 (increased) in PD versus SD patients (p<0.05). …”
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1455
Experimental and Numerical Investigations of Soot Formation in the Laminar to Turbulent Transition of an Acetylene Diffusion Flame
Published 2025“…Soot formation from incomplete hydrocarbon combustion poses significant challenges for emission control in propulsion systems. …”
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1456
Image 3_Age-period-cohort analysis of syphilis epidemics in Eastern China, China, 2005–2024.jpeg
Published 2025“…The reported incidence of syphilis decreased by an average of −3.53% per year across all age groups (95% CI: −4.34, −2.70%). …”
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1457
Image 2_Age-period-cohort analysis of syphilis epidemics in Eastern China, China, 2005–2024.jpeg
Published 2025“…The reported incidence of syphilis decreased by an average of −3.53% per year across all age groups (95% CI: −4.34, −2.70%). …”
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1458
Data Sheet 3_Esophageal cancer mortality trends in the United States: a comprehensive longitudinal study (1999–2023) using CDC WONDER data.xlsx
Published 2025“…Background<p>Esophageal cancer continues to pose a significant public health challenge worldwide. However, the extent to which advancements in treatment have reduced mortality at the population level remains unclear. …”
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1459
Image 1_Esophageal cancer mortality trends in the United States: a comprehensive longitudinal study (1999–2023) using CDC WONDER data.tif
Published 2025“…Background<p>Esophageal cancer continues to pose a significant public health challenge worldwide. However, the extent to which advancements in treatment have reduced mortality at the population level remains unclear. …”
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1460
Image 2_Esophageal cancer mortality trends in the United States: a comprehensive longitudinal study (1999–2023) using CDC WONDER data.tif
Published 2025“…Background<p>Esophageal cancer continues to pose a significant public health challenge worldwide. However, the extent to which advancements in treatment have reduced mortality at the population level remains unclear. …”