بدائل البحث:
significant challenges » significant challenge (توسيع البحث), significant changes (توسيع البحث)
significant decrease » significant increase (توسيع البحث), significantly increased (توسيع البحث)
challenges decrease » challenges case (توسيع البحث)
significant challenges » significant challenge (توسيع البحث), significant changes (توسيع البحث)
significant decrease » significant increase (توسيع البحث), significantly increased (توسيع البحث)
challenges decrease » challenges case (توسيع البحث)
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1561
Data Sheet 1_Global burden of Type 2 Diabetes Mellitus attributable to dietary risks in elderly adults: insights from the Global Burden of Disease study 2021.docx
منشور في 2025"…Background<p>Type 2 Diabetes Mellitus (T2DM) poses a significant global health challenge, particularly among elderly adults. …"
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1562
Table 1_Case Report: Application of accelerated continuous theta burst stimulation in treatment-resistant depression.docx
منشور في 2025"…<p>Treatment-resistant depression (TRD) poses a significant challenge in psychiatric practice. While repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising non-invasive neuromodulation technique for TRD, a subset of patients fails to respond adequately to these traditional rTMS protocols. …"
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1563
Data Sheet 1_Use of HLA desensitization in the management of renal transplant recipients in Europe.pdf
منشور في 2025"…<p>A significant challenge in kidney transplantation is overcoming immunological barriers such as human leukocyte antigen (HLA) incompatibilities. …"
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1564
Image 1_PipC affects the virulence of Salmonella enterica serovar Enteritidis and its deletion strain provides effective immune protection in mice.tif
منشور في 2025"…The results of the mouse intraperitoneal challenge experiment showed that compared with the wild-type strain, the 50% lethal dose (LD<sub>50</sub>) of the ΔpipC strain increased by 47 times, and the bacterial loads in the liver, spleen, and cecum were significantly reduced. …"
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1565
The feasibility of the Todoist application to assist students with time management
منشور في 2025"…Students verified through direct interviews that their poor time management skills represent a significant academic challenge. The analysis emphasises the importance of students managing their time effectively during their academic journey and recommends Todoist as a helpful tool to address this challenge. …"
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1566
Data Sheet 1_Yeast culture improves growth, antioxidant status, immunity, and gut microbiota homeostasis in preweaning Holstein calves.csv
منشور في 2025"…Serum levels of total antioxidant capacity (T-AOC), total superoxide dismutase (T-SOD), and glutathione peroxidase (GSH-Px) were significantly elevated, while malondialdehyde (MDA) content was significantly decreased (p < 0.05), indicating improved antioxidant status. …"
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1567
Table 1_Yeast culture improves growth, antioxidant status, immunity, and gut microbiota homeostasis in preweaning Holstein calves.docx
منشور في 2025"…Serum levels of total antioxidant capacity (T-AOC), total superoxide dismutase (T-SOD), and glutathione peroxidase (GSH-Px) were significantly elevated, while malondialdehyde (MDA) content was significantly decreased (p < 0.05), indicating improved antioxidant status. …"
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1568
Table_1_Effectiveness of sofosbuvir-based treatments for patients with hepatitis C virus genotype 6 infection: a real-world study from East China.DOC
منشور في 2024"…Background<p>Over the past decade, the proportion of hepatitis C virus (HCV) genotypes (GT) 1 and 2 has decreased in almost all regions of China, while GT 3 and 6 have emerged as new challenges. …"
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1569
Data Sheet 1_Global, regional, and national burden and trends of intracerebral hemorrhage among adolescents and young adults aged 15–39 years from 1990 to 2021: a comprehensive tre...
منشور في 2025"…Background<p>Intracerebral hemorrhage (ICH) poses a significant health challenge, notably affecting adolescents and young adults (AYAs) aged 15–39 years. …"
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1570
Table 1_Long-term oyster shell powder applications increase crop yields and control soil acidity and cadmium in red soil drylands.docx
منشور في 2025"…While the short-term use of soil amendments has shown significant potential for mitigating these challenges, few studies have explored their long-term effects on acidified soils and heavy metal accumulation. …"
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1571
Table 1_Optimization of the scale-up production process for high-yield laccase from white-rot fungi.docx
منشور في 2025"…Dissolved oxygen (DO) was a crucial factor for high laccase yield, and its maintenance at a high level in the fermentation system significantly enhanced the enzyme activity. Fermentation batches with varying laccase production levels exhibited a trend of decreasing pH and a subsequent increase in the mid-to-late fermentation stages. …"
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1572
Table 1_Global burden trends of tension-type headache, 1990–2021: socio-demographic patterns, age-period-cohort effects, and frontier analysis from the GBD 2021 study.docx
منشور في 2025"…Contrasting trends emerged: globally and in High and High-middle SDI regions rates decreased, while Middle SDI regions showed significant increases (prevalence: +5.83%). …"
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1573
Table 2_Global burden trends of tension-type headache, 1990–2021: socio-demographic patterns, age-period-cohort effects, and frontier analysis from the GBD 2021 study.docx
منشور في 2025"…Contrasting trends emerged: globally and in High and High-middle SDI regions rates decreased, while Middle SDI regions showed significant increases (prevalence: +5.83%). …"
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1574
Data Sheet 1_Exogenous putrescine modulates variety-specific cadmium tolerance in wheat seedlings: synergistic roles of antioxidant defense and physiological homeostasis.pdf
منشور في 2025"…Introduction<p>Cadmium (Cd) contamination in farmland is a significant environmental issues affecting crop yields. …"
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1575
Table 3_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.docx
منشور في 2025"…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …"
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1576
Image 3_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.tif
منشور في 2025"…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …"
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1577
Table 5_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.docx
منشور في 2025"…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …"
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1578
Image 2_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.tif
منشور في 2025"…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …"
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1579
DataSheet1_CircFOXO3 upregulation mediates the radioresistance of glioblastoma by affecting cellular metabolome.DOCX
منشور في 2024"…Introduction<p>Radioresistance remains a significant challenge in the treatment of glioblastoma multiforme (GBM), the most prevalent and lethal brain cancer in adults. …"
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1580
Table1_CircFOXO3 upregulation mediates the radioresistance of glioblastoma by affecting cellular metabolome.XLSX
منشور في 2024"…Introduction<p>Radioresistance remains a significant challenge in the treatment of glioblastoma multiforme (GBM), the most prevalent and lethal brain cancer in adults. …"