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significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
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significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
challenges decrease » challenges case (Expand Search)
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1581
Table 1_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.docx
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1582
Table 4_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.docx
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1583
Table 2_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.docx
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1584
Data Sheet 1_Integrated computational and experimental identification of N-[(1H-1,2,4-triazol-3-yl)phenyl]-1-(1H-pyrazolo[3,4-b]pyridin-3-yl)methanamide as a potent and selective T...
Published 2025“…<p>Non-small cell lung cancer (NSCLC) remains a significant clinical challenge, necessitating exploration of novel therapeutic targets such as TIM-3. …”
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1585
Image 1_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.tif
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1586
Data Sheet 1_Effectiveness of community-based management models in chronic obstructive pulmonary disease: a systematic review and meta-analysis.docx
Published 2025“…Telemedicine management also significantly reduced the frequency of acute exacerbations of COPD (MD = −0 0.56; 95% CI [−0.79, −0.32], p < 0.00001). …”
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1587
Table 1_Global burden of disease changes related to high red meat diets and breast cancer from 1990 to 2021 and its prediction up to 2030.docx
Published 2025“…</p>Conclusion<p>From 1990 to 2021, the global age-standardized rate of the breast cancer disease burden decreased, but disparities between regions with different SDI levels remain a major challenge. …”
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1588
Nyamsuren, I., Mitchell, E., and Tsay, J. (April 27 - May 2, 2025), <i>Learning Sign Language with Real-Time Kinematic Feedback</i> [Poster Presentation]. The Annual Meeting of the...
Published 2025“…This growing demand emphasizes the significance of sign language—not just as a communication tool, but as a key to ensuring equal participation in society.…”
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1589
Data Sheet 1_A longitudinal study on perceived burdensomeness and its influencing factors among older adult hemodialysis patients who migrated with their families in China.pdf
Published 2025“…The family support scores showed a gradually decreasing trend (T1: 10.25 ± 1.91, T2: 9.70 ± 1.84, and T3: 9.13 ± 1.88). …”
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1590
Data Sheet 1_Workplace harassment is associated with differences in personality traits, coping strategies and work ability: cross sectional study among healthcare professionals.pdf
Published 2025“…Exposure to WPH is associated with decreased work ability. Low rate of formal reporting reveals systemic gaps in institutional responses. …”
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1591
Table 2_Temporary trigeminal ganglion stimulation can improve zoster-related trigeminal neuralgia: a retrospective study in a single center.docx
Published 2025“…At the six-month follow-up, the mean VAS score decreased from preoperative 6.1 ± 1.5 to 2.5 ± 1.9, demonstrating a statistically significant reduction (t = 4.36, p < 0.05). …”
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1592
Table 1_Temporary trigeminal ganglion stimulation can improve zoster-related trigeminal neuralgia: a retrospective study in a single center.docx
Published 2025“…At the six-month follow-up, the mean VAS score decreased from preoperative 6.1 ± 1.5 to 2.5 ± 1.9, demonstrating a statistically significant reduction (t = 4.36, p < 0.05). …”
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1593
Image 2_Temporary trigeminal ganglion stimulation can improve zoster-related trigeminal neuralgia: a retrospective study in a single center.tif
Published 2025“…At the six-month follow-up, the mean VAS score decreased from preoperative 6.1 ± 1.5 to 2.5 ± 1.9, demonstrating a statistically significant reduction (t = 4.36, p < 0.05). …”
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1594
Image 1_Temporary trigeminal ganglion stimulation can improve zoster-related trigeminal neuralgia: a retrospective study in a single center.tif
Published 2025“…At the six-month follow-up, the mean VAS score decreased from preoperative 6.1 ± 1.5 to 2.5 ± 1.9, demonstrating a statistically significant reduction (t = 4.36, p < 0.05). …”
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1595
Global, regional, and national trends in colorectal cancer from 2010 to 2021: an analysis of the global burden of disease study 2021
Published 2025“…<p>Colorectal cancer (CRC) is a major global health challenge due to its high incidence and mortality rates. …”
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1596
Investigating the effects of ankle foot orthoses on electromyography in impaired populations: a systematic review
Published 2025“…</p><p>Longitudinal studies refute concerns about adverse effects on EMG activity with prolonged AFO use, challenging the notion of decreased muscle activation and supporting the safety of extended AFO utilization.…”
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1597
Table1_Local sediment amendment can potentially increase barley yield and reduce the need for phosphorus fertilizer on acidic soils in Kenya.DOCX
Published 2024“…The Baringo 3% amendment significantly increased soil pH (from 4.7 to 7.0), the available P content (from 0.01 mg g<sup>−1</sup> to 0.02 mg g<sup>−1</sup>) and decreased the Al availability (from 3.03 mg g<sup>−1</sup>–2.17 mg g<sup>−1</sup>). …”
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1598
Data Sheet 1_Prevalence trends, population characteristics and treatment outcomes of tuberculosis combined with diabetes in Southwest China: a register-based retrospective study.do...
Published 2024“…Background<p>The global situation regarding the prevention and control of pulmonary tuberculosis (PTB) remains challenging. With the ongoing aging population and the increasing prevalence of chronic diseases, the epidemic of comorbid pulmonary tuberculosis and diabetes mellitus (PTB-DM) presents challenges to PTB control. …”
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1599
Data Sheet 1_Impact of multiple environmental factors on influenza–like illness in Fujian Province, China, 2015–2023: a multicity study.zip
Published 2025“…Introduction<p>Influenza-like illness (ILI) represents a significant global public health challenge influenced by environmental factors. …”
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1600
Data_Sheet_1_A novel chimeric endolysin Cly2v shows potential in treating streptococci-induced bovine mastitis and systemic infections.docx
Published 2024“…Additionally, in a systemic infection model, treatment with Cly2v (400 μg/mouse) provided protection rates of up to 100 and 78% against S. agalactiae ATCC13813 infections when challenged for 1 h and 3 h, respectively. Furthermore, a significant reduction in bacterial loads was observed in the blood and organs compared to the PBS group. …”