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significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
challenges decrease » challenges case (Expand Search)
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1601
Data Sheet 1_Global, regional and national burden of decubitus ulcers in 204 countries and territories from 1990 to 2021: a systematic analysis based on the global burden of diseas...
Published 2025“…Background<p>Decubitus ulcers, also known as pressure ulcers, pose a significant public health challenge due to their substantial impact on morbidity, mortality, and healthcare expenditures.…”
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1602
Table 1_The role of eosinophils and their activation state in hypereosinophilia-associated heart disease.pdf
Published 2025“…</p>Results<p>Mice challenged with the myocarditic and control peptide had peripheral blood leukocytosis, but only those challenged with the myocarditic peptide had heart inflammation. …”
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1603
Presentation 1_The role of eosinophils and their activation state in hypereosinophilia-associated heart disease.pdf
Published 2025“…</p>Results<p>Mice challenged with the myocarditic and control peptide had peripheral blood leukocytosis, but only those challenged with the myocarditic peptide had heart inflammation. …”
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1604
Table 2_The role of eosinophils and their activation state in hypereosinophilia-associated heart disease.xlsx
Published 2025“…</p>Results<p>Mice challenged with the myocarditic and control peptide had peripheral blood leukocytosis, but only those challenged with the myocarditic peptide had heart inflammation. …”
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1605
SEAwise Report on the impacts of fisheries on stocks and landings under SEAwise EBFM
Published 2025“…The ecosystem model generally showed less optimistic outcomes under climate change, with significant decreases in biomass and catches in both the Celtic and North Seas. …”
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1606
The impact of chronic pain on the quality of life of patients attending soshanguve community health centre (CHC), Tshwane district, South Africa
Published 2025“…<p dir="ltr">Background: Chronic pain poses a considerable challenge to individuals' well-being, leading to decreased quality of life, limitations in daily functioning, and a higher reliance on healthcare services, resulting in significant economic burdens. …”
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1607
Video 2_Efficacy of P62-expressing plasmid in treatment of canine osteoarthritis pain: a pilot study.mp4
Published 2025“…Traditional OA management consist of non-steroidal anti-inflammatory drugs and remains challenging because of significant side effects, thus there is an urgent need for new effective and safe therapeutics for OA.…”
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1608
Video 3_Efficacy of P62-expressing plasmid in treatment of canine osteoarthritis pain: a pilot study.mp4
Published 2025“…Traditional OA management consist of non-steroidal anti-inflammatory drugs and remains challenging because of significant side effects, thus there is an urgent need for new effective and safe therapeutics for OA.…”
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1609
Supplementary file 1_Efficacy of flavonoids in non-alcoholic fatty liver disease: an updated systematic review and meta-analysis.docx
Published 2025“…Flavonoids intervention significantly decreased aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT), total cholesterol (TC), steatosis score, body mass index (BMI), triglycerides (TG), fasting blood sugar (FBS), insulin levels and augmented the quantitative insulin sensitivity check index (QUICKI) levels. …”
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1610
Video 1_Efficacy of P62-expressing plasmid in treatment of canine osteoarthritis pain: a pilot study.mp4
Published 2025“…Traditional OA management consist of non-steroidal anti-inflammatory drugs and remains challenging because of significant side effects, thus there is an urgent need for new effective and safe therapeutics for OA.…”
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1611
Data Sheet 1_Global burden, trends and inequalities of maternal hypertensive disorders among reproductive-age women of advanced maternal age, 1990–2021: a population-based study.pd...
Published 2025“…Background<p>Maternal hypertensive disorders (MHD) are leading causes of maternal morbidity and mortality worldwide, particularly among reproductive-age women of advanced maternal age (AMA), representing a significant global public health challenge.</p>Objective<p>This study aimed to analyze the global trends, inequalities, and disparities in the burden of MHD among reproductive-age AMA women from 1990 to 2021.…”
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1612
Data Sheet 1_Biomarker-based risk assessment of dietary intervention in patients with coronary artery disease during cardiac rehabilitation—a quasi-experimental study.pdf
Published 2025“…Total cholesterol, LDL, and triglyceride levels also decreased in all groups during CR without significant differences (p ≥ 0.3957). …”
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1613
Data Sheet 1_Mechanistic insights into pyrolysis temperature-dependent lead (Pb) stabilization in phytoremediation residue-derived biochar.docx
Published 2025“…<p>The substantial generation of hazardous, metal-enriched biomass residues poses significant risks of secondary contamination, presenting a critical bottleneck to the broader implementation of phytoremediation that urgently requires effective treatment solutions. …”
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1614
Data Sheet 1_Global, regional, and national burden of interstitial lung disease in middle-aged and older adults from 1990 to 2021 with projections to 2050: a systematic analysis of...
Published 2025“…Background<p>Interstitial lung disease (ILD) constitutes a significant global health challenge. However, existing epidemiological studies predominantly focus on worldwide and regional distribution patterns, while a substantial knowledge gap persists regarding the epidemiological characteristics of ILD among middle-aged and older adults (50–74 years). …”
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1615
Table 1_Spatio-temporal patterns and determinants of persistent catastrophic health expenditure in China: evidence from the China Family Panel Studies.docx
Published 2025“…Background<p>The escalating out-of-pocket medical expenses pose a significant threat to the financial stability of households worldwide. …”
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1616
Presentation 2_Rethinking pre-training: cognitive load implications for learners with varying prior knowledge.pdf
Published 2025“…While learners with lower prior knowledge did not show significant reductions in intrinsic load, they benefited from decreased extraneous load during problem-solving. …”
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1617
Presentation 1_Rethinking pre-training: cognitive load implications for learners with varying prior knowledge.pdf
Published 2025“…While learners with lower prior knowledge did not show significant reductions in intrinsic load, they benefited from decreased extraneous load during problem-solving. …”
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1618
Image 1_Rethinking pre-training: cognitive load implications for learners with varying prior knowledge.png
Published 2025“…While learners with lower prior knowledge did not show significant reductions in intrinsic load, they benefited from decreased extraneous load during problem-solving. …”
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1619
Unveiling the molecular legacy of transient insulin resistance: Implications for hepatic metabolic adaptability (Sup Tables). Berthier et al. J. Hepatol. 2025
Published 2025“…</p><h3>Conclusions</h3><p dir="ltr">Seemingly reversible metabolic challenges in early adulthood may predispose the liver to exacerbated metabolic dysfunctions when confronted with chronic challenges later in life.…”
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1620
Automated matching and visualisation of magnetic flux leakage data in shale gas pipeline based on ICP and DBSCAN algorithm
Published 2025“…Despite many pipelines have completed two or more rounds of internal inspection and have accumulated substantial data, effectively analyzing and utilizing this MFL data remains a significant challenge. To that end, this study proposes a novel combined model that integrates Iterative Closest Point (ICP) and DBSCAN (Density-Based Spatial Clustering of Applications with Noise) fusion to match multiple MFL data. …”