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significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
challenges decrease » challenges case (Expand Search)
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1621
Table 1_GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells.xlsx
Published 2025“…However, resistance to EGFR inhibitors, such as erlotinib, presents a significant challenge in treating lung cancer. In this study, we established an EGFR-independent, erlotinib-resistant (ER) phenotype in lung cancer A549 cells by exposing them to erlotinib for an extended period. …”
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1622
Supplementary Material for: Relationships between Skin Structure and Skin Function of Pregnant Women and Their Infants: A Prospective Cohort Study
Published 2025“…In women during pregnancy and in infants during the first months after birth skin health is challenged. However, evidence about the structural and functional changes of the skin during and after pregnancy is largely lacking. …”
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1623
Data Sheet 1_GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells.pdf
Published 2025“…However, resistance to EGFR inhibitors, such as erlotinib, presents a significant challenge in treating lung cancer. In this study, we established an EGFR-independent, erlotinib-resistant (ER) phenotype in lung cancer A549 cells by exposing them to erlotinib for an extended period. …”
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1624
Data Sheet 1_Global burden of inflammatory bowel disease in the elderly: trends from 1990 to 2021 and projections to 2051.docx
Published 2024“…</p>Conclusion<p>The absolute burden of IBD in the elderly population is projected to increase substantially by 2051, despite decreasing ASRs. These findings underscore the need for tailored healthcare strategies and resource allocation to address the growing challenge of elderly IBD globally.…”
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1625
Table 1_D-amino acid enhanced the sensitivity of avian pathogenic Escherichia coli to tetracycline and amikacin.doc
Published 2025“…<p>Avian pathogenic Escherichia coli (APEC) biofilm formation has led to increased antibiotic resistance, presenting a significant challenge for the prevention and control of the disease. …”
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1626
Table 2_D-amino acid enhanced the sensitivity of avian pathogenic Escherichia coli to tetracycline and amikacin.docx
Published 2025“…<p>Avian pathogenic Escherichia coli (APEC) biofilm formation has led to increased antibiotic resistance, presenting a significant challenge for the prevention and control of the disease. …”
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1627
Changes in the effective optical zone following hyperopic keratorefractive lenticule extraction
Published 2025“…</p> <p>The EOZ continued decreasing following hyperopic KLEx. A larger TZ and POZ would result in a larger postoperative EOZ.…”
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1628
Thymoquinone loaded nanoemulgel in streptozotocin induced diabetic wound
Published 2024“…</p> <p>In diabetic wound animal model nanoemulgel showed significant decreased levels of TNF-α, IL-6, MMP-9 and IL-1β. …”
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1629
Image 2_Load-bearing aerobic exercise prior to injury moderates systemic immunosuppression response to fracture.jpeg
Published 2025“…Subjects that exercised before fracture had decreased post-fracture circulating immunosuppressive myeloid-derived suppressor cells and pain sensitivity, however there was no significant effect of prehabilitation on bone repair volume, defect bridging rate, or biomechanical properties. …”
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1630
Competition constrains the resistance and recovery of fungi to heat stress under low nutrient concentration
Published 2025“…Yet, we know little about how biotic interactions among fungi, such as competition, may influence fungal stability against environmental stresses. For instance, a significant challenge is understanding the roles of competition in driving resistance (immediate response to stress) and recovery (response after the stress is over) of fungi under climate extremes, such as heat waves, particularly under variable resource availability. …”
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1631
Table 1_Load-bearing aerobic exercise prior to injury moderates systemic immunosuppression response to fracture.docx
Published 2025“…Subjects that exercised before fracture had decreased post-fracture circulating immunosuppressive myeloid-derived suppressor cells and pain sensitivity, however there was no significant effect of prehabilitation on bone repair volume, defect bridging rate, or biomechanical properties. …”
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1632
Table 2_Load-bearing aerobic exercise prior to injury moderates systemic immunosuppression response to fracture.docx
Published 2025“…Subjects that exercised before fracture had decreased post-fracture circulating immunosuppressive myeloid-derived suppressor cells and pain sensitivity, however there was no significant effect of prehabilitation on bone repair volume, defect bridging rate, or biomechanical properties. …”
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1633
Image 1_Load-bearing aerobic exercise prior to injury moderates systemic immunosuppression response to fracture.jpeg
Published 2025“…Subjects that exercised before fracture had decreased post-fracture circulating immunosuppressive myeloid-derived suppressor cells and pain sensitivity, however there was no significant effect of prehabilitation on bone repair volume, defect bridging rate, or biomechanical properties. …”
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1634
Data Sheet 1_China’s readiness for transitioning to a low-carbon economy: mitigant and catalyst factors for a geopolitical conflict.zip
Published 2025“…This study examines the relationship between Low-Carbon Economic Development (LCED) and Geopolitical Risk (GPR) in China by focusing on the challenges and opportunities they present. We use a qualitative analysis to identify that rising GPR, exacerbated by market instability, resource allocation conflicts, and trade disputes, significantly hinders LCED progress. …”
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1635
Data Sheet 1_Psychological Well-Being in Adults Across the COVID-19 Pandemic: A Two-Year Longitudinal Study.docx
Published 2025“…Decreasing or consistently low well-being was significantly associated with younger age, limited social support, caregiving responsibilities, concerns about COVID-19 infection, and stress due to pandemic-related changes.…”
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1636
Data Sheet 1_Global, regional, and national time trends in falls and their predictions: an age-period-cohort analysis of the Global Burden of Disease Study 2021.pdf
Published 2025“…These findings underscore the urgent need for age- and region-specific interventions to address this public health challenge.</p>…”
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1637
Table 1_Improved medical protective clothing comfort for medical staff facing high-intensity infectious diseases.docx
Published 2025“…</p>Methods<p>To address this challenge, a novel integrated MPC was developed through the recombination of mainstream materials. …”
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1638
Supplementary Material for: Delayed Onset of Central Serous Chorioretinopathy (CSCR) following corticosteroid treatment for Giant Cell Arteritis (GCA): A Case Report
Published 2025“…The patient presented with decreased vision in the left eye for 10 days, prompting ophthalmologic evaluation. …”
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1639
Data Sheet 1_Associations between glycan signature alterations and the cellular antigenic properties of passaged chondrocytes.docx
Published 2024“…Background<p>Cartilage repair is a significant clinical challenge because of the limited intrinsic healing capacity. …”
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1640
Datasheet1_Combined endovascular interventions for pulmonary embolism at high altitude in Tibet.zip
Published 2024“…The heart rate (p < 0.05) and respiratory rate (p < 0.001) of all enrolled patients were significantly decreased, and the peripheral capillary oxygen saturation (SpO2) was significantly increased (p < 0.05) after interventions. …”