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significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
challenges decrease » challenges case (Expand Search)
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1721
Image 1_Ozone promotes macrophage efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway.tif
Published 2024“…Background<p>Neuropathic pain (NPP) is a multifaceted pain syndrome that occurs as a consequence of physical injury or underlying diseases, with an incidence rate of 7%-10%, NPP poses a significant clinical challenge as current treatment options are ineffective. …”
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1722
Table 1_PitNET tissue deconvolution: tracing normal tissue residues and immune dynamics.xlsx
Published 2025“…However, its limited ability to resolve cellular heterogeneity – particularly in samples containing residual non-tumor pituitary cells – remains a significant challenge.</p>Objective<p>We developed and validated a tissue deconvolution framework using a reference dataset derived from single-nucleus RNA sequencing (snRNA-seq) of normal pituitary tissue, aimed at estimating cellular composition in PitNETs from bulk RNA-seq data and characterizing the tumor microenvironment (TME).…”
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1723
Data Sheet 6_Global, regional, and national burdens of pancreatitis in children and adolescents aged 0–24 years from 1992 to 2021: a trend analysis based on the global burden of di...
Published 2025“…Background<p>The younger onset of pancreatitis presents a significant public health challenge. This study aims to analyze the global burden of pancreatitis in younger populations based on the Global Burden of Disease 2021.…”
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1724
Improved antidiabetic potential of quercetin-loaded chitosan–lecithin nanoparticles for effective glycaemic control
Published 2025“…<p>Diabetes mellitus is a major global health challenge, causing significant morbidity and mortality. …”
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1725
Video 4_Ozone promotes macrophage efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway.mp4
Published 2024“…Background<p>Neuropathic pain (NPP) is a multifaceted pain syndrome that occurs as a consequence of physical injury or underlying diseases, with an incidence rate of 7%-10%, NPP poses a significant clinical challenge as current treatment options are ineffective. …”
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1726
Data Sheet 8_Global, regional, and national burdens of pancreatitis in children and adolescents aged 0–24 years from 1992 to 2021: a trend analysis based on the global burden of di...
Published 2025“…Background<p>The younger onset of pancreatitis presents a significant public health challenge. This study aims to analyze the global burden of pancreatitis in younger populations based on the Global Burden of Disease 2021.…”
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1727
Image_2_Cytomegalovirus results in poor graft function via bone marrow-derived endothelial progenitor cells.PNG
Published 2024“…Introduction<p>Poor graft function (PGF), characterized by myelosuppression, represents a significant challenge following allogeneic hematopoietic stem cell transplantation (allo-HSCT) with human cytomegalovirus (HCMV) being established as a risk factor for PGF. …”
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1728
Image 6_Ozone promotes macrophage efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway.tif
Published 2024“…Background<p>Neuropathic pain (NPP) is a multifaceted pain syndrome that occurs as a consequence of physical injury or underlying diseases, with an incidence rate of 7%-10%, NPP poses a significant clinical challenge as current treatment options are ineffective. …”
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1729
Data Sheet 2_Global, regional, and national burdens of pancreatitis in children and adolescents aged 0–24 years from 1992 to 2021: a trend analysis based on the global burden of di...
Published 2025“…Background<p>The younger onset of pancreatitis presents a significant public health challenge. This study aims to analyze the global burden of pancreatitis in younger populations based on the Global Burden of Disease 2021.…”
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1730
Video 3_Ozone promotes macrophage efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway.mp4
Published 2024“…Background<p>Neuropathic pain (NPP) is a multifaceted pain syndrome that occurs as a consequence of physical injury or underlying diseases, with an incidence rate of 7%-10%, NPP poses a significant clinical challenge as current treatment options are ineffective. …”
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1731
Video 2_Ozone promotes macrophage efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway.mp4
Published 2024“…Background<p>Neuropathic pain (NPP) is a multifaceted pain syndrome that occurs as a consequence of physical injury or underlying diseases, with an incidence rate of 7%-10%, NPP poses a significant clinical challenge as current treatment options are ineffective. …”
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1732
Data Sheet 5_Global, regional, and national burdens of pancreatitis in children and adolescents aged 0–24 years from 1992 to 2021: a trend analysis based on the global burden of di...
Published 2025“…Background<p>The younger onset of pancreatitis presents a significant public health challenge. This study aims to analyze the global burden of pancreatitis in younger populations based on the Global Burden of Disease 2021.…”
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1733
Presentation 1_Global patterns of change in the burden of malnutrition in older adults from 1990 to 2021 and the forecast for the next 25 years.pdf
Published 2025“…Background<p>Malnutrition poses a significant public health challenge, particularly as the global population ages. …”
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1734
Data Sheet 2_Ozone promotes macrophage efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway.xlsx
Published 2024“…Background<p>Neuropathic pain (NPP) is a multifaceted pain syndrome that occurs as a consequence of physical injury or underlying diseases, with an incidence rate of 7%-10%, NPP poses a significant clinical challenge as current treatment options are ineffective. …”
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1735
Innovation in a Post-Oil City: Moving Design Away from Carbon Dependency
Published 2025“…This unconscious act increases the ability to imagine while decreasing the possibilities for low-carbon and responsible innovation. …”
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1736
Video 1_Ozone promotes macrophage efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway.mp4
Published 2024“…Background<p>Neuropathic pain (NPP) is a multifaceted pain syndrome that occurs as a consequence of physical injury or underlying diseases, with an incidence rate of 7%-10%, NPP poses a significant clinical challenge as current treatment options are ineffective. …”
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1737
Image 2_Ozone promotes macrophage efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway.tif
Published 2024“…Background<p>Neuropathic pain (NPP) is a multifaceted pain syndrome that occurs as a consequence of physical injury or underlying diseases, with an incidence rate of 7%-10%, NPP poses a significant clinical challenge as current treatment options are ineffective. …”
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1738
Supplementary Material for: Non-Prescribed Use of Opioid Agonist Medications and Associations with Non-Fatal Overdoses: A Repeated Cross-Sectional Study Across a Decade of Reduced...
Published 2025“…Multinomial regression analyses showed no significant association between non-prescribed OAT use and increased risk of non-fatal overdoses. …”
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1739
Data Sheet 1_Global, regional, and national burdens of pancreatitis in children and adolescents aged 0–24 years from 1992 to 2021: a trend analysis based on the global burden of di...
Published 2025“…Background<p>The younger onset of pancreatitis presents a significant public health challenge. This study aims to analyze the global burden of pancreatitis in younger populations based on the Global Burden of Disease 2021.…”
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1740
Enamel matrix derivative in the treatment of tooth replantation: from a biological basis to clinical application
Published 2024“…Although the pooled outcomes suggested increased incidence of surface resorption (RR=1.19, <i>P</i>=0.730) and decreased risk of inflammation resorption (RR=0.68, <i>P</i>=0.560) among replanted teeth with resorption in the EMD-treated group, neither difference was statistically significant.…”