يعرض 1,881 - 1,900 نتائج من 2,040 نتيجة بحث عن '(( significant decrease decrease ) OR ( significant challenges decrease ))~', وقت الاستعلام: 0.26s تنقيح النتائج
  1. 1881

    Data Sheet 2_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.docx حسب Lina Ouologuem (22489549)

    منشور في 2025
    "…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. …"
  2. 1882

    Video 4_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 حسب Lina Ouologuem (22489549)

    منشور في 2025
    "…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. …"
  3. 1883

    Data Sheet 1_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.docx حسب Lina Ouologuem (22489549)

    منشور في 2025
    "…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. …"
  4. 1884

    Data Sheet 1_IDO1-AhR axis increases T regulatory cells in Plasmodium vivax malaria infection.pdf حسب Rafaella Oliveira dos Santos (21710366)

    منشور في 2025
    "…Introduction<p>Malaria remains a significant public health challenge in Brazil, where Plasmodium vivax (P. vivax) is the predominant species. …"
  5. 1885

    Video 3_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 حسب Lina Ouologuem (22489549)

    منشور في 2025
    "…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. …"
  6. 1886

    Video 7_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 حسب Lina Ouologuem (22489549)

    منشور في 2025
    "…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. …"
  7. 1887

    Image1_Efficacy and Safety of a Polysaccharide-Based Natural Substance Complex in the Treatment of Obesity and Other Metabolic Syndrome Components: A Systematic Review.TIF حسب Giuseppina Guarino (6795282)

    منشور في 2024
    "…However, preventing and treating MetS is one of the most pressing challenges for public health services worldwide. At present, the only approved treatments for MetS are dietary changes and physical activity, which are associated with a high rate of non-compliance. …"
  8. 1888

    AjMLKL is involved in 10<sup>8</sup> CFU/mL AJ01 induced lytic coelomocyte death independent on its phosphorylation. حسب Kaiyu Chen (11691918)

    منشور في 2025
    "…Treatment of sea cucumber coelomocytes with 100 μM GW806724X for 3 h and then challenged by 10<sup>8</sup> CFU/mL AJ01. Coelomocyte viability was significantly increased (L), and coelomocytes plasma membrane disruption (M) and the percentage of Annexin V+/PI+ coelomocytes significantly decreased (N). …"
  9. 1889

    Description of study characteristics. حسب Feline de la Court (15194678)

    منشور في 2025
    "…Loss of PrEP retention rates were significantly (p < 0.05) lower in studies from Europe, Australia and multiple regions (vs. …"
  10. 1890

    DataSheet1_Effects of mesenchymal stromal cells and human recombinant Nerve Growth Factor delivered by bioengineered human corneal lenticule on an innovative model of diabetic reti... حسب Letizia Pelusi (9606879)

    منشور في 2024
    "…In the last years, mesenchymal stromal cells (MSCs) and neurotrophins like Nerve Growth Factor (NGF), have garnered significant attention as innovative therapeutic approaches targeting DR-associated neurodegeneration. …"
  11. 1891

    Image 1_Regulation effect of seed priming on sowing rate of direct seeding of rice under salt stress.pdf حسب Yicheng Zhang (790286)

    منشور في 2025
    "…However, the global intensification of soil salinization presents a significant challenge to food security. Increasing sowing rates is a common practice to enhance germination under salt stress, although it leads to higher seed costs. …"
  12. 1892

    Table 1_CD9 regulates proliferation, invasion, migration and radioresistance of esophageal squamous cell carcinoma by activating AKT/GSK3β signaling pathway.docx حسب Liubing Hou (10888140)

    منشور في 2025
    "…Background<p>Radioresistance poses a major therapeutic challenge in ESCC, significantly impacting patient prognosis. …"
  13. 1893

    Table 1_Regulation effect of seed priming on sowing rate of direct seeding of rice under salt stress.pdf حسب Yicheng Zhang (790286)

    منشور في 2025
    "…However, the global intensification of soil salinization presents a significant challenge to food security. Increasing sowing rates is a common practice to enhance germination under salt stress, although it leads to higher seed costs. …"
  14. 1894

    Accommodating talker variability in noise (Zhang & Peng, 2025) حسب Kaile Zhang (21763791)

    منشور في 2025
    "…However, high noise levels significantly hinder this ability. BN presents greater challenges than BMN at lower SNRs, likely due to increased informational masking. …"
  15. 1895

    Data Sheet 1_The efficacy and safety of panax quinquefolius saponin for heart failure: a systematic review and meta-analysis.pdf حسب Jing Wang (6206297)

    منشور في 2025
    "…Background<p>Heart failure (HF) is a global health concern, affecting millions of individuals worldwide and leading to significant morbidity and mortality. Despite advances in conventional therapeutic strategies, the prognosis for HF patients remains challenging, and there is a constant search for novel therapeutic options. …"
  16. 1896

    Update on trimethylamine N-oxide (TMAO) as a piezolyte and cryoprotectant: its role in a depth limit for marine fishes and loss from hadal fish during capture حسب Paul Yancey (14354982)

    منشور في 2025
    "…<p dir="ltr"><b>I</b><b>NTRODUCTION</b></p><p dir="ltr">Trimethylamine N-oxide (TMAO) is a small organic molecule found at osmotically-significant concentrations in many marine animal taxa. …"
  17. 1897

    Applications of Human Biostasis in Crewed Space Exploration حسب Josh Universe (21186797)

    منشور في 2025
    "…These achievements provide critical context for the future challenges humanity will face as it pushes further into space.…"
  18. 1898

    Factors affecting LLINs usage at household level. حسب Job Oyweri (22041452)

    منشور في 2025
    "…Bed ownership was 50.8% in the pyrethroid-LLIN group and 55.3% in the PBO-LLIN group. Not owning a bed decreased the likelihood of net usage by 13.3% [aOR=0.867 (95% CI = 0.816–0.920), p < 0.001]. …"
  19. 1899

    Net usage across intervention arms. حسب Job Oyweri (22041452)

    منشور في 2025
    "…Bed ownership was 50.8% in the pyrethroid-LLIN group and 55.3% in the PBO-LLIN group. Not owning a bed decreased the likelihood of net usage by 13.3% [aOR=0.867 (95% CI = 0.816–0.920), p < 0.001]. …"
  20. 1900

    Factors associated with malaria infection. حسب Job Oyweri (22041452)

    منشور في 2025
    "…Bed ownership was 50.8% in the pyrethroid-LLIN group and 55.3% in the PBO-LLIN group. Not owning a bed decreased the likelihood of net usage by 13.3% [aOR=0.867 (95% CI = 0.816–0.920), p < 0.001]. …"