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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
significant change » significant changes (Expand Search), significant challenge (Expand Search), significant challenges (Expand Search)
change decrease » change increases (Expand Search), change degree (Expand Search)
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6361
Image 2_Probiotic Bacillus pumilus LV149 enhances gut repair, modulates microbiota, and alters transcriptome in DSS-induced colitis mice.tif
Published 2025“…Notably, only the LV149-H significantly decreased the expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, while both doses increased the expression of the anti-inflammatory cytokine IL-10 in a dose-dependent in colonic tissue. …”
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6362
Table 1_Probiotic Bacillus pumilus LV149 enhances gut repair, modulates microbiota, and alters transcriptome in DSS-induced colitis mice.xlsx
Published 2025“…Notably, only the LV149-H significantly decreased the expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, while both doses increased the expression of the anti-inflammatory cytokine IL-10 in a dose-dependent in colonic tissue. …”
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6363
Table 1_Weizmannia coagulans BC99 regulates oxidative stress and serum metabolic pathways to improve allergic rhinitis: a randomized, double-blind, placebo-controlled trial.docx
Published 2025“…Furthermore, BC99 supplementation significantly decreased serum IgA, complement C3, EOS, and MDA levels (p < 0.05) while enhancing antioxidant capacity (increased GSH, stabilized SOD). …”
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6364
Image 4_Probiotic Bacillus pumilus LV149 enhances gut repair, modulates microbiota, and alters transcriptome in DSS-induced colitis mice.tif
Published 2025“…Notably, only the LV149-H significantly decreased the expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, while both doses increased the expression of the anti-inflammatory cytokine IL-10 in a dose-dependent in colonic tissue. …”
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6365
Data_Sheet_1_Effect of synbiotic supplementation on obesity and gut microbiota in obese adults: a double-blind randomized controlled trial.docx
Published 2024“…</p>Results<p>Synbiotics supplementation significantly decreased body fat percentage, waist, and serum low-density lipoprotein cholesterol (LDL-C), increased peptide YY, cholecystokinin, oxyntomodulin, GSH (glutathione peroxidase) in individuals with obesity. …”
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6366
Table 2_Age-Period-Cohort analysis and 2036 projections of the burden of ischemic stroke in Finland, Korea, Singapore and China, 1990–2021.xlsx
Published 2025“…Objective<p>To analyze the temporal changes in ischemic stroke incidence and prevalence and their correlations with age, period, and birth cohort from 1990 to 2021 in Finland, Korea, Singapore and China, and to predict the trends of incidence and number of cases in 2036.…”
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6367
Supplementary file 3_Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.jpeg
Published 2025“…</p>Results and Discussion<p>Calycosin significantly reduced neurological impairments and brain infarction in a dose-dependent manner, alleviated neuronal damage and decreased the expression of pyroptosis-related markers, including NLRP3, GSDMD, HMGB1, IL-1β, IL-18, and caspase-1. …”
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6368
Image 6_Study on the ecosystem service flow based on the relationship of between supply and demand in Yangtze River Economic Belt.jpeg
Published 2024“…From 2015 to 2020, the number of areas with balanced supply and demand of ecosystem services in the Yangtze River Economic Belt decreases and the number of areas with unbalanced supply and demand increases, which is related to the changes in the level of economic development and land use patterns. 3). …”
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6369
Supplementary file 4_Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.docx
Published 2025“…</p>Results and Discussion<p>Calycosin significantly reduced neurological impairments and brain infarction in a dose-dependent manner, alleviated neuronal damage and decreased the expression of pyroptosis-related markers, including NLRP3, GSDMD, HMGB1, IL-1β, IL-18, and caspase-1. …”
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6370
Image 2_Viral encephalitis and seizures cause rapid depletion of neuronal progenitor cells and alter neurogenesis in the adult mouse dentate gyrus.tif
Published 2025“…They resumed proliferation at 14 dpi, but, did not recover to CTR levels, and displayed aberrant migration patterns. (2) The number of proliferating NSCs significantly decreased within the dorsal DG of TMEV mice at 14 dpi compared to CTR, while (3) a heightened population of proliferating astrocytes was observed. …”
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6371
Data Sheet 1_Case Report: Late diagnosis of McCune-Albright with severe kyphoscoliosis, acromegaly and tertiary hyperparathyroidism.pdf
Published 2025“…Bone scintigraphy revealed increased tracer uptake in multiple skeletal system parts, corresponding to degenerative changes. Genetic testing using Sanger sequencing was negative for MEN1 and CDKN1B mutations but revealed a common germline, heterozygous GNAS variant NM_000516.7:c.531-13_531-10del (rs576071932) – classified as a variant of uncertain significance (RCV000597562.1) with a minor allele frequency of 0.265%. …”
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6372
Image_3_Loss of Cdc42 causes abnormal optic cup morphogenesis and microphthalmia in mouse.JPEG
Published 2024“…EdU incorporation is significantly downregulated. In addition, mitotic retinal progenitor cells mislocalize deeper, basal regions, likely contributing to decreased proliferation. …”
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6373
Table 1_Angiotensin converting enzyme inhibitors and angiotensin receptor blockers impact on the gut microbiome: a systematic review.docx
Published 2025“…In the human study, ACEi/ARB use did not significantly alter microbial diversity, but decreased populations of facultative aerobic pathogens including Staphylococcus and Enterobacterales. …”
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6374
Table 4_Age-Period-Cohort analysis and 2036 projections of the burden of ischemic stroke in Finland, Korea, Singapore and China, 1990–2021.xlsx
Published 2025“…Objective<p>To analyze the temporal changes in ischemic stroke incidence and prevalence and their correlations with age, period, and birth cohort from 1990 to 2021 in Finland, Korea, Singapore and China, and to predict the trends of incidence and number of cases in 2036.…”
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6375
Data Sheet 1_Galangin reduces MPTP-induced dopamine neuron injury via the autophagy dependent-PI3K/AKT pathway.pdf
Published 2025“…Moreover, the expression of significantly different genes in the Galangin-treated group and model group analyzed by transcriptomics was basically consistent with the qRT-PCR verification results.…”
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6376
Table_2_ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1.docx
Published 2025“…This reduction correlated with changes in the expression of autophagic activity markers, suggesting decreased basal levels of autophagy in primary and metastatic melanomas. …”
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6377
Table 5_Age-Period-Cohort analysis and 2036 projections of the burden of ischemic stroke in Finland, Korea, Singapore and China, 1990–2021.xlsx
Published 2025“…Objective<p>To analyze the temporal changes in ischemic stroke incidence and prevalence and their correlations with age, period, and birth cohort from 1990 to 2021 in Finland, Korea, Singapore and China, and to predict the trends of incidence and number of cases in 2036.…”
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6378
Table_2_Diffusion and functional MRI reveal microstructural and network connectivity impairment in adult-onset neuronal intranuclear inclusion disease.docx
Published 2024“…</p>Results<p>Compared with the HCs, NIID patients showed reduced mean kurtosis (MK), radial kurtosis (RK), axial kurtosis (AK), and kurtosis fractional anisotropy (KFA) values in deep gray matter regions. Significantly decreased MK, RK, AK, KFA and fractional anisotropy (FA), and increased mean diffusivity (MD) values were observed in extensive white matter fiber tracts. …”
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6379
Table 1_Neonatal supplementation of oleamide during suckling ameliorates maternal postpartum sleep interruption-induced neural impairment and endocannabinoid dysfunction in early a...
Published 2025“…Introduction<p>Postpartum sleep disturbances in women are common and can significantly affect maternal mental health and breastfeeding. …”
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6380