Data_Sheet_1_Genetically predicted serum metabolites mediate the association between inflammatory proteins and polycystic ovary syndrome: a Mendelian randomization study.CSV حسب Ming-Jie Jia (18267391)

"…</p>Results<p>The IVW method revealed that the inflammatory proteins IFN-γ (p-value = 0.037, OR = 1.396, 95% CI = 1.020–1.910) and CCL7 (p-value = 0.033, OR = 1.294, 95% CI = 1.021–1.641) were associated with an increased risk of PCOS, while IL-6 (p-value = 0.015, OR = 0.678, 95% CI = 0.495–0.929) and MMP-10 (p-value = 0.025, OR = 0.753, 95% CI = 0.587–0.967) were associated with a decreased risk. No significant evidence suggested an effect of genetically predicted PCOS on inflammatory proteins. …"

Data_Sheet_2_Genetically predicted serum metabolites mediate the association between inflammatory proteins and polycystic ovary syndrome: a Mendelian randomization study.CSV حسب Ming-Jie Jia (18267391)

"…</p>Results<p>The IVW method revealed that the inflammatory proteins IFN-γ (p-value = 0.037, OR = 1.396, 95% CI = 1.020–1.910) and CCL7 (p-value = 0.033, OR = 1.294, 95% CI = 1.021–1.641) were associated with an increased risk of PCOS, while IL-6 (p-value = 0.015, OR = 0.678, 95% CI = 0.495–0.929) and MMP-10 (p-value = 0.025, OR = 0.753, 95% CI = 0.587–0.967) were associated with a decreased risk. No significant evidence suggested an effect of genetically predicted PCOS on inflammatory proteins. …"

Data Sheet 1_Oxyresveratrol as a novel ferroptosis inducer exhibits anticancer activity against breast cancer via the EGFR/PI3K/AKT/GPX4 signalling axis.pdf حسب Lei Xiang (528500)

"…Introduction<p>Oxyresveratrol (ORes) exhibits significant anticancer activity, particularly against breast cancer. …"

Table 1_Sex-specific association between triglyceride-glucose index and all-cause mortality in patients with osteoporotic fractures: a retrospective cohort study.docx حسب Shao-han Guo (19690687)

"…TyG-I indicated a statistically significant relation with sex (P for interaction = 0.01).…"

Supplementary file 1_Sex-specific association between triglyceride-glucose index and all-cause mortality in patients with osteoporotic fractures: a retrospective cohort study.xlsx حسب Shao-han Guo (19690687)

"…TyG-I indicated a statistically significant relation with sex (P for interaction = 0.01).…"

Table 1_Study on Chaiyuwendan decoction’s inhibition of hippocampal neuron apoptosis to alleviating depression by activating the AKT/CREB pathway.docx حسب Shaoliang Zhang (7523498)

"…Chaiyuwendan decoction (CYWD) has significant clinical efficacy in treating depression, however, its specific mechanism is still unclear. …"

Data Sheet 1_The role of ATP6V0D2 in breast cancer: associations with prognosis, immune characteristics, and TNBC progression.docx حسب Jingyu Zhang (256203)

"…Objective<p>Researches have identified ATPase H+ transporting V0 subunit d2 (ATP6V0D2) as a significant factor in various cancers. However, its prognostic value in breast cancer (BRCA) and its biological role in BRCA cells remain unclear.…"

Image 1_Association of estimated glucose disposal rate with chronic kidney disease: comparative analysis against traditional insulin resistance indices.jpeg حسب Yuanxin Liu (6307949)

"…Background<p>Chronic kidney disease (CKD) is a widespread condition, marked by significant morbidity and mortality rates, particularly in individuals with comorbidities such as diabetes and hypertension. …"

Data Sheet 1_Impact of liposomal bupivacaine on subjective recovery quality after surgery: a meta-analysis of randomized controlled trials.docx حسب Longyi Zhang (11120151)

"…The LB group also exhibited lower cumulative morphine-equivalent opioid consumption within 72 h after surgery, a reduced incidence of PONV, and significantly higher patient satisfaction scores.</p>Conclusion<p>The use of LB was associated with improved QoR scores within 72 h after surgery, a reduced incidence of PONV, and decreased opioid consumption. …"

Data_Sheet_1_Long-term phenobarbital treatment is effective in working-age patients with epilepsy in rural Northeast China: a 10-year follow-up study.docx حسب Rongxin Li (3552779)

"…</p>Methods<p>Patients aged 18–65 years diagnosed with convulsive epilepsy in rural areas of Jilin Province between 2010 and 2024 were included, and demographic and clinical data were recorded. Seizure frequency, self-efficacy, adherence, and adverse events (AEs) were assessed monthly.…"

Data Sheet 1_Astaxanthin mitigates doxorubicin-induced cardiotoxicity via inhibiting ferroptosis and autophagy: a study based on bioinformatic analysis and in vivo/vitro experiment... حسب Bowen Yin (11925053)

"…This has substantial practical significance for the clinical application of DOX.</p>Methods<p>Bioinformatic analyses were conducted using transcriptomic data from the gene expression omnibus (GEO) database to identify key mechanisms underlying DIC. …"

Data Sheet 2_Astaxanthin mitigates doxorubicin-induced cardiotoxicity via inhibiting ferroptosis and autophagy: a study based on bioinformatic analysis and in vivo/vitro experiment... حسب Bowen Yin (11925053)

"…This has substantial practical significance for the clinical application of DOX.</p>Methods<p>Bioinformatic analyses were conducted using transcriptomic data from the gene expression omnibus (GEO) database to identify key mechanisms underlying DIC. …"

Table 1_The mitochondrial function of peripheral blood cells in cognitive frailty patients.docx حسب Li Qin (205731)

"…</p>Conclusion<p>Age, lower educational attainment, malnutrition, and depression are significant risk factors for CF. Moreover, mitochondrial dysfunction, characterized by decreased mtDNAcn, impaired respiratory function and increased ROS levels appears to be a critical phenotype of CF.…"

Multicomponent physical exercise program among community-dwelling older adults who are users of home care services: a quasi-experimental pilot study حسب Aida Ruiz-Fernández (22822586)

"…Group-by-time analyses suggested improvements in the MPEP group for the Short Physical Performance Battery (η²ₚ=0.154) and Fried Frailty Scale (η²ₚ=0.164). Frailty decreased on both scales (OR = 0.142 and 0.125). No further significant effects were observed.…"

Data Sheet 1_Association of estimated glucose disposal rate with atrial fibrillation, heart failure and cardiovascular mortality in patients with diabetes: a prospective cohort stu... حسب Zhen Tan (384977)

"…</p>Conclusions<p>This study demonstrated that higher eGDR levels were associated with a decreased risk of AF, HF, and cardiovascular mortality. …"

Data Sheet 1_Efficacy and safety of PCSK9 inhibitors, potent statins, and their combinations for reducing low-density lipoprotein cholesterol in hyperlipidemia patients: a systemat... حسب Yuhua Jiang (10300159)

"…</p>Results<p>A total of 68 clinical studies involving 21,288 patients with hyperlipidemia were incorporated into the NMA. …"

Data Sheet 1_Unveiling causal immune cell–gene associations in multiple myeloma: insights from systematic reviews and Mendelian randomization analyses.docx حسب Hui Zhang (7197)

"…NCAM1 also exhibited a significant methylation-level association with disease.…"

Data Sheet 1_Impact of mini-dose dexmedetomidine supplemented analgesia on sleep structure in patients at high risk of obstructive sleep apnea: a pilot trial.docx حسب Pei Sun (115160)

"…Other sleep structure and sleep-respiratory parameters did not differ significantly between the two groups. Subjective sleep quality was slightly improved with dexmedetomidine on the night of surgery, but not statistically significant (median difference, 6; 95% CI, 0 to 13; p = 0.060). …"

Table 9_Exploring Histoplasma species seroprevalence and risk factors for seropositivity in The Gambia’s working equid population: Baseline analysis of the Tackling Histoplasmosis... حسب Tessa Rose Cornell (15460726)

"…Following informed owner consent, equid clinical and management data were recorded. Blood samples were collected by jugular venepuncture, and sera were subject to the IMMY Latex Agglutination Histoplasma test (LAT). …"

Table 1_Exploring Histoplasma species seroprevalence and risk factors for seropositivity in The Gambia’s working equid population: Baseline analysis of the Tackling Histoplasmosis... حسب Tessa Rose Cornell (15460726)

"…Following informed owner consent, equid clinical and management data were recorded. Blood samples were collected by jugular venepuncture, and sera were subject to the IMMY Latex Agglutination Histoplasma test (LAT). …"