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421
Treatment consequence and adverse events of cyclin-dependent kinase 4/6 inhibitors on patients with hormone receptor-positive, HER2-negative metastatic breast cancer: a systematic...
Published 2025“…</p> <p>CDK4/6 inhibitor combined with endocrine therapy can prolong progression-free survival, overall survival, objective response rate, and clinical benefit rate, and decrease progressive disease rate.</p> <p>Hematological toxicities are the main concern for CDK4/6 inhibitors. …”
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422
Table 1_Dividend announcements and share price dynamics: new evidence from Saudi-listed companies using event study approach.docx
Published 2025“…Furthermore, results demonstrate that the abnormal return is negative but not significantly different from zero at the time of the announcement of a decrease in the dividend payment level. …”
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423
Data Sheet 1_Temporal dynamics of summer phytoplankton communities and their response to environmental changes in the northern Yellow Sea (2011-2020).docx
Published 2025“…The results indicated a significant decrease in dissolved inorganic nitrogen (DIN) concentration after 2011, resulting in a decreased N/P ratio, while phosphorus limitation persisted. …”
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424
Longitudinal study on changes in COVID-19 vaccination intentions in Benin and Senegal: Insights from Generalized Estimating Equations (GEE)
Published 2025“…Differences emerged: perceived efficacy and behavioral control were significant in Benin, while safety concerns were a major barrier in Senegal. …”
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425
Liquid mosquito repellent induces toxic effects in zebrafish
Published 2024“…While these products demonstrate significant efficacy, the toxicological implications associated with their use are not yet fully understood and continue to be a subject of debate. …”
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426
Supplementary Material for: A case report of adult lead-poisoning followed by use of non-prescription Ayurvedic medication in Germany
Published 2025“…The patient responded well to DMSA therapy, with subsequent serum lead levels showing a marked decrease to 86 µg/L at 10-month follow-up. She tolerated the treatment without significant adverse effects and is in good health, able to engage fully in both her personal and professional life. …”
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427
Multimorbidity and health related quality of life in midlife – a longitudinal study from Northern Finland Birth Cohort 1966
Published 2025“…</p> <p>In general, HRQoL decreased during 15-year follow-up for everyone. Furthermore, decrease in the quality of life is significantly associated with multimorbidity in this longitudinal setting.…”
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428
Table 1_Dietary supplementation with proanthocyanidins and rutin alleviates the symptoms of type 2 diabetes mice and regulates gut microbiota.xlsx
Published 2025“…Background<p>Obesity and high fasting blood glucose (FBG) resulting from high-fat diets (HFDs) have emerged as significant public health concerns, garnering increasing attention. …”
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429
Image 1_Dietary supplementation with proanthocyanidins and rutin alleviates the symptoms of type 2 diabetes mice and regulates gut microbiota.png
Published 2025“…Background<p>Obesity and high fasting blood glucose (FBG) resulting from high-fat diets (HFDs) have emerged as significant public health concerns, garnering increasing attention. …”
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430
Data Sheet 1_Non-stationary response of Pacific saury (Cololabis saira) in the northwestern Pacific to climate variability.docx
Published 2025“…The dynamics of Pacific saury from 1970 to 2021 could be divided into four periods: the 1970s and 1980s when the Siberian High and the intensification of the East Asian winter monsoon drove down the water temperature, providing a suitable habitat and resulting in an increase in resource abundance; In the 1990s, the rise in temperature led to a reduction in resource abundance; At the beginning of the 21st century, the enhancement of the Siberian High brought about a suitable habitat, and the resource abundance showed a significant increase; The unfavorable high water temperature environment in the 2010s caused the resource abundance to decrease once again. …”
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431
Supplementary Material for: Yoga Asana Increases Pre-Frontal Cortex Activity and Reduces Resting State Functional Connectivity
Published 2025“…Furthermore, analysis of short-term changes in resting-state functional connectivity (rsFC) revealed a significant decrease, primarily in the left medial prefrontal cortex (PFC), a key region of the default mode network (DMN), an area known to exhibit heightened activity in individuals suffering from depression and anxiety Conclusion: This study provides neurological insight into the effects of yoga asana and supports fNIRS for assessing movement-based practices in real-world settings.…”
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432
Data_Sheet_1_Using differential reinforcement for all to manage disruptive behaviors: three class interventions at kindergarten and primary school.docx
Published 2024“…However, the results of all three interventions showed a significant decrease in the frequency of disruptive behaviors after the strategy implementation. …”
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433
Data Sheet 1_Numerical modeling of the influence of tidal flats on estuaries: the case of the Guadalquivir estuary, SW of the Iberian Peninsula.docx
Published 2025“…Introduction<p>Tidal flats play a crucial role in estuarine dynamics, yet their degradation due to human activities raises concerns about their ecological and hydrodynamic implications.…”
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434
Data_Sheet_1_Dynamics of urban development patterns on thermal distributions and their implications on water spread areas of Vellore, Tamil Nadu, India.docx
Published 2024“…Moreover, spatial and time series analyses of WSAs indicated a significant increase in LST. Furthermore, a strong negative correlation was found between WSA and LST, with a 10% decrease in WSA potentially increasing LST by 0.12°C to 0.55°C in surrounding regions. …”
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435
Data_Sheet_1_Dynamics of urban development patterns on thermal distributions and their implications on water spread areas of Vellore, Tamil Nadu, India.docx
Published 2024“…Moreover, spatial and time series analyses of WSAs indicated a significant increase in LST. Furthermore, a strong negative correlation was found between WSA and LST, with a 10% decrease in WSA potentially increasing LST by 0.12°C to 0.55°C in surrounding regions. …”
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436
pone.0331193.t003 -
Published 2025“…</p><p>Background</p><p>Cognitive decline is a significant concern in aging populations, with research suggesting that neuroplasticity and cognitive reserve can be enhanced through targeted cognitive training. …”
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437
Baseline characteristics by group.
Published 2025“…</p><p>Background</p><p>Cognitive decline is a significant concern in aging populations, with research suggesting that neuroplasticity and cognitive reserve can be enhanced through targeted cognitive training. …”
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438
Table 1_Effects of icariin as a feed additive on the reproductive function in bucks (Capra hircus).docx
Published 2024“…However, the serum concentration of GnRH in the ICA group initially increased, followed by a subsequent decrease (p < 0.05). The hypothalamic concentrations of dopamine (DA) and 5-hydroxytryptamine (5-HT) were significantly higher in the ICA group compared to the control group (p < 0.01). …”
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439
Data Sheet 1_Effects of icariin as a feed additive on the reproductive function in bucks (Capra hircus).docx
Published 2024“…However, the serum concentration of GnRH in the ICA group initially increased, followed by a subsequent decrease (p < 0.05). The hypothalamic concentrations of dopamine (DA) and 5-hydroxytryptamine (5-HT) were significantly higher in the ICA group compared to the control group (p < 0.01). …”
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440
Table 1_Temporal trends of cervical cancer demographics: a CDC WONDER database study.docx
Published 2025“…Between 2015 and 2023, there was a concerning positive change in AAMR [APC of 0.1272 (95% CI –0.3393 to 1.7502)], though not statistically significant. …”