Data Sheet 2_Qinggan Yipi capsule ameliorates hepatic fibrosis in rats by down-regulating the TGF-β1/Smad2/3 signaling pathway and improving gut microbiota imbalance.pdf by Wenjing Xue (2880686)

“…</p>Results<p>Histopathological analysis, serum biochemical tests, and ELISA measurements showed that QgYp effectively decreased the levels of ALT, AST, HA, LN, PCIII, and IV-C while improving collagen deposition and hepatocyte necrosis. …”

Data Sheet 1_Guanxinning attenuates diabetic myocardial ischemia–reperfusion injury by targeting oral Fusobacterium nucleatum and modulating PTEN signaling.docx by Yiwen Li (354034)

“…</p>Results<p>GXN treatment significantly reduced myocardial injury in diabetic mice and decreased oral F. nucleatum abundance, although its effects on other gut microbiota taxa were variable. …”

Table 1_Lyophyllum decastes-derived polysaccharides alleviate DSS-induced colitis in mice by suppressing inflammation, enhancing intestinal barrier integrity, and restoring gut mic... by Eslam Ghaleb (21698810)

“…Additionally, LDP improved intestinal barrier function by reducing MPO activity and enhancing occludin and ZO-1 expression. 16S rRNA sequencing revealed a significant restoration of gut microbiota diversity, with an increase in beneficial bacteria Muribaculaceae, Lactobacillus, and Lachnospiraceae, and a reduction in pathogenic bacteria Escherichia-Shigella. these findings suggest that LDP exhibits therapeutic effects in DSS-induced colitis through anti-inflammatory properties, enhancement of intestinal barrier function, and modulation of gut microbiota. …”

Azole drugs have differential efficacy in varied models of immunosuppression in larval zebrafish hosts by Kevin E. Ayala (21979064)

“…Two triazole antifungal drugs, voriconazole and posaconazole, were broadly effective in animals experiencing both genetically-induced and drug-induced immunosupression, while isavuconazole and itraconazole had decreased efficacy or increased toxicity in some cases. …”

Image 1_Metformin enhances alpelisib sensitivity in HER2+ breast cancer by suppressing cancer stemness and oncogenic signaling.tif by Yujie Shi (737203)

“…Metformin enhanced these effects, demonstrating strong synergism. Combination treatment induced significant G0/G1 cell-cycle arrest, reduced ALDH1⁺ populations, and decreased tumorsphere formation. …”

Table 2_High intake of n-6 polyunsaturated fatty acid exacerbates non-alcoholic steatohepatitis by the involvement of multiple metabolic pathways.docx by Jian-Tong (21583487)

“…The combined pathway alterations in the D1 group increased inflammation, leading to elevated NF-κB expression, Kupffer cell polarization to M1, and lipid peroxidation, with n-6 PUFA interacting with choline deficiency to exacerbate these effects. Correlational analysis revealed significant associations between these pathways and inflammatory/oxidative markers. …”

Image 2_Guanxinning attenuates diabetic myocardial ischemia–reperfusion injury by targeting oral Fusobacterium nucleatum and modulating PTEN signaling.jpeg by Yiwen Li (354034)

“…</p>Results<p>GXN treatment significantly reduced myocardial injury in diabetic mice and decreased oral F. nucleatum abundance, although its effects on other gut microbiota taxa were variable. …”

Image 1_Guanxinning attenuates diabetic myocardial ischemia–reperfusion injury by targeting oral Fusobacterium nucleatum and modulating PTEN signaling.png by Yiwen Li (354034)

“…</p>Results<p>GXN treatment significantly reduced myocardial injury in diabetic mice and decreased oral F. nucleatum abundance, although its effects on other gut microbiota taxa were variable. …”

Table 1_Guanxinning attenuates diabetic myocardial ischemia–reperfusion injury by targeting oral Fusobacterium nucleatum and modulating PTEN signaling.xlsx by Yiwen Li (354034)

“…</p>Results<p>GXN treatment significantly reduced myocardial injury in diabetic mice and decreased oral F. nucleatum abundance, although its effects on other gut microbiota taxa were variable. …”

Table 2_Guanxinning attenuates diabetic myocardial ischemia–reperfusion injury by targeting oral Fusobacterium nucleatum and modulating PTEN signaling.xlsx by Yiwen Li (354034)

“…</p>Results<p>GXN treatment significantly reduced myocardial injury in diabetic mice and decreased oral F. nucleatum abundance, although its effects on other gut microbiota taxa were variable. …”

Table 1_Enrichment of short-chain fatty acid-producing bacteria by pH-responsive sodium alginate and chitosan-encapsulated quercetin.docx by Qianyu Bai (21992984)

“…Compared to the DSS group, the SA-Q-CS MPs treatment group showed significant improvements, with the Disease Activity Index (DAI) and histopathological scores reduced by more than 66.9%, pro-inflammatory factor levels decreased by 65%, antioxidant levels increased over sevenfold, and tight junction protein expression elevated by more than threefold. …”

Table 1_High intake of n-6 polyunsaturated fatty acid exacerbates non-alcoholic steatohepatitis by the involvement of multiple metabolic pathways.docx by Jian-Tong (21583487)

“…The combined pathway alterations in the D1 group increased inflammation, leading to elevated NF-κB expression, Kupffer cell polarization to M1, and lipid peroxidation, with n-6 PUFA interacting with choline deficiency to exacerbate these effects. Correlational analysis revealed significant associations between these pathways and inflammatory/oxidative markers. …”

Data Sheet 1_YOLOv8 forestry pest recognition based on improved re-parametric convolution.docx by Lina Zhang (112887)

“…Traditional pest detection methods are often inefficient and inaccurate in complex environments, posing significant challenges for effective pest management. …”

Climate is more influential to vegetation green-up than factors that contribute to erosion following high-severity wildfire by Joseph Crockett (22077659)

“…In <a>highly erodible</a> scenarios, when accounting for growing season climate, coefficient of variation for year-of-fire precipitation, total precipitation, and soil erodibility decreased greenness in the fifth year. While the effects of year-of-fire factors related to erosion were significant, they were small, and the variability explained by growing season vapor pressure deficit and growing season precipitation were significantly greater.…”

Data Sheet 1_Interstitial fluid transport in linea alba is involved in acupuncture-induced attenuation of ovarian hypofunction in aged rats.pdf by Yaoyao Zhu (3487937)

“…Background<p>Age-related ovarian dysfunction, characterized by declining follicular reserve and hormonal imbalance, poses a significant challenge in reproductive endocrinology, severely compromising fertility and quality of life. …”

Table 1_Efficacy and mechanism of cyprosulfamide in alleviating the phytotoxicity of clomazone residue on maize seedling.xlsx by Lanlan Sun (1798921)

“…The findings revealed that the application of CSA effectively mitigated the inhibitory effects of Clo residues on maize plant height, fresh weight, carotenoids and chlorophyll content. …”

Mitigating toxicity of arsenic in sunflower (<i>Helianthus annuus</i> L.) with phosphate rock and farmyard manure using contrasting soil textures by Muhammad Awais Piracha (21234904)

“…</p> <p>Numerous studies investigate the ameliorating effect of phosphorus (P) and organic amendments to mitigate As stress. …”

Data Sheet 1_Dehydrozaluzanin C inhibits colon cancer cell proliferation, apoptosis and cycle arrest through peroxisome proliferator-activated receptor γ (PPARγ) activation.pdf by Shan-Shan Li (436534)

“…In vivo, DC treatment significantly decreased the weight and volume of xenograft tumor tissues in mice and apoptosis-related protein levels. …”

Data Sheet 4_Global, regional, and national burden of musculoskeletal disorders, 1990–2021: an analysis of the global burden of disease study 2021 and forecast to 2035.pdf by Meizhi Liu (21898892)

“…Frontier analysis revealed significant gaps between current burdens and achievable benchmarks, particularly in high-SDI regions, while some low-SDI regions demonstrated effective management despite limited resources. …”

Data Sheet 1_Does chlorhexidine improve periodontal health and bacterial profiles in patients with special health care needs? A systematic review and meta-analysis.docx by Deepak Sharma (131639)

“…Gingival inflammation also decreased significantly across studies (mean difference = −0.214; 95% CI: −0.306 to −0.121; P < .001), with 0.2% CHX formulations demonstrating the most consistent improvement.…”