Rinderine suppresses African swine fever virus replication in porcine alveolar macrophages by dual targeting of membrane-associated profilin 1 and phosphatidylethanolamine by Di Liu (30843)

“…Mechanistically, mass spectrometry-based cellular thermal shift assay, further experimental validation and molecular docking analysis indicate that profilin 1 (PFN1) is a key target protein mediating the inhibitory effects of RIN on ASFV attachment to PAMs. Structural prediction analysis, co-immunoprecipitation assay, and confocal microscopy demonstrate that RIN disrupts the interaction between PFN1 and actin, thereby decreasing the actin remodelling. …”

Supplementary Material for: Efficacy of Spray Cryotherapy on Airway Secretions in Canine Models of Chronic Bronchitis and Mechanism Insights by Wang B. (4026758)

“…Conclusion The SO2 inhalation protocol effectively establishes a CB model in dogs. SCT effectively treats CB by reducing mucin levels and may lower MUC5AC expression by decreasing acetylcholine and CHRM3.…”

Image2_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer’s d... by Huijing Ren (19986303)

“…Interference with this pathway significantly influenced the therapeutic effects of CPGB in the 3D-NVU model. …”

DataSheet1_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer... by Huijing Ren (19986303)

“…Interference with this pathway significantly influenced the therapeutic effects of CPGB in the 3D-NVU model. …”

Image1_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer’s d... by Huijing Ren (19986303)

“…Interference with this pathway significantly influenced the therapeutic effects of CPGB in the 3D-NVU model. …”

Impact of acute binge-like ethanol exposure during the third-trimester equivalent on subicular interneurons in mice by Katalina M. Lopez (21821714)

“…Adolescent neuronal density was significantly decreased in exposed males’ distal dorsal subiculum (<i>p</i> < .0001, g = −0.8). …”

Raw images. by Dahae Lee (3125157)

“…PPD, Rg1, Rb2, and Rg3 inhibited lipid accumulation in PA-treated HepG2 cells. PA significantly decreased lipid levels in HepG2 cells, which was prevented by PPD, Rg1, Rb2, and Rg3. …”

Table1_Berberine alleviates ETEC-induced intestinal inflammation and oxidative stress damage by optimizing intestinal microbial composition in a weaned piglet model.docx by Yue Wang (65477)

“…</p>Results<p>Berberine significantly improved the final body weight (BW), average daily gain (ADG), and average daily feed intake (ADFI) (P<0.05) of piglets, and effectively decreased the incidence of diarrhea among the animals (P<0.05). …”

Soluble average Klotho level as a prognostic marker for acute kidney injury outcomes: a 90-day follow-up study by ShaSha Li (12163175)

“…</p> <p>The sKlotho level decreased significantly with kidney injury and represented severity. …”

Image 1_Subepicardial adipose genes contribute to the deterioration of heart failure preserved ejection fraction.tif by Ruiying Zhang (3569693)

“…However, why visceral adipocytes show different effects on healthy and ageing cardiomyocytes is less known.…”

Data Sheet 1_Subepicardial adipose genes contribute to the deterioration of heart failure preserved ejection fraction.pdf by Ruiying Zhang (3569693)

“…However, why visceral adipocytes show different effects on healthy and ageing cardiomyocytes is less known.…”

Image 2_Subepicardial adipose genes contribute to the deterioration of heart failure preserved ejection fraction.tiff by Ruiying Zhang (3569693)

“…However, why visceral adipocytes show different effects on healthy and ageing cardiomyocytes is less known.…”

Data Sheet 2_Ophiopogonin D improves pancreatic islet cell dedifferentiation to treat diabetes by regulating the GRP78/ROS/PDX1 signaling pathway.doc by Haoxiang Sun (6396902)

“…Ophiopogonin D (Op D) exhibits certain hypoglycemic effects; however, its mechanisms remain unclear.</p>Methods<p>β-cell dedifferentiation, distinct from β-cell apoptosis, is a pathogenic mechanism we aim to explore regarding Op D’s regulatory effects. …”

Data Sheet 1_Ophiopogonin D improves pancreatic islet cell dedifferentiation to treat diabetes by regulating the GRP78/ROS/PDX1 signaling pathway.doc by Haoxiang Sun (6396902)

“…Ophiopogonin D (Op D) exhibits certain hypoglycemic effects; however, its mechanisms remain unclear.</p>Methods<p>β-cell dedifferentiation, distinct from β-cell apoptosis, is a pathogenic mechanism we aim to explore regarding Op D’s regulatory effects. …”

Lingganwuweijiangxin Decoction suppresses allergic airway inflammation in Guinea pigs with cough variant asthma by regulating the treg/Th17 balance and the JAK1/STAT6 signaling pat... by Yu Lai (764498)

“…Moreover, LD treatment increased <i>Foxp3</i> mRNA (<i>p</i> = 0.0013) and protein expression (<i>p</i> < 0.0001) and reduced <i>RORγt</i> mRNA (<i>p</i> < 0.0001). LD also decreased <i>JAK1</i> and <i>STAT6</i> transcription (<i>p</i> = 0.0021, <i>p</i> < 0.0001, respectively), with consistent effects observed at the protein level (<i>p</i> < 0.0001).…”

Table 1_Guiren Runchang granules alleviate slow transit constipation in mice by modulating gut microbiota and short-chain fatty acids.docx by Xinfeng Bai (5049932)

“…Specifically, the relative abundance of the genera Alloprevotella and Muribaculum increased, while that of Prevotellaceae_NK3B31_group, Ruminococcus, and Lachnospiraceae_UCG-001 decreased. These microbiota changes were significantly correlated with SCFAs level, motility-related hormone concentrations, and defecation phenotype. …”

Table 2_Modified maxillomandibular advancement for Eastern Asian patients with moderate or severe OSA: an anatomic and aerodynamic assessment of the upper airway.xlsx by Kan Li (490394)

“…The apnea–hypopnea index (36.05 ± 17.68 vs. 5.72 ± 4.76, p < 0.001) and the ESS (13.23 ± 8.9 vs. 6.23 ± 6.81 events/h, p < 0.05) decreased significantly, while the lowest oxygen saturation (76.54 ± 10.26% vs. 84.77 ± 6.02%, p < 0.05) improved greatly. …”

Table 1_Modified maxillomandibular advancement for Eastern Asian patients with moderate or severe OSA: an anatomic and aerodynamic assessment of the upper airway.xlsx by Kan Li (490394)

“…The apnea–hypopnea index (36.05 ± 17.68 vs. 5.72 ± 4.76, p < 0.001) and the ESS (13.23 ± 8.9 vs. 6.23 ± 6.81 events/h, p < 0.05) decreased significantly, while the lowest oxygen saturation (76.54 ± 10.26% vs. 84.77 ± 6.02%, p < 0.05) improved greatly. …”

Data Sheet 1_Comprehensive analysis of SQOR involvement in ferroptosis resistance of pancreatic ductal adenocarcinoma in hypoxic environments.zip by Quan Lin (5958)

“…SQOR knockdown resulted in decreased cell viability, decreased migration ability and increased MDA level under hypoxic Ersatin induced conditions. …”

<b>Litter decomposition regulated by stand ECM dominance but not litter mycorrhizal type in a subtropical mountainous forest</b> by Lu Mengzhen (20146224)

“…</a> AM and ECM litter decomposition in plots with a natural gradient of ECM tree dominance showed that the decomposition rates of both AM litter and ECM litter decreased significantly in plots with increasing ECM dominance. …”