Search alternatives:
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
significant effect » significant impact (Expand Search)
effect decrease » effects decreased (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
significant effect » significant impact (Expand Search)
effect decrease » effects decreased (Expand Search)
-
10341
Table 5_Therapeutic potential of luteolin in central precocious puberty: insights from a danazol-induced rat model.docx
Published 2025“…</p>Results<p>In the danazol-induced CPP model, luteolin treatment significantly decreased the abundances of Estradiol (E2), luteinizing hormone serum, and follicle-stimulating hormone in sera; reduced organ coefficients and ovarian and uterine wet weights; and delayed vaginal opening. …”
-
10342
Maresin-1 alleviates sepsis-induced acute kidney injury by inhibiting ferroptosis via the Nrf2/HO-1/Gpx4 signaling pathway
Published 2025“…Nrf2 knockdown was used to validate its role in MaR-1-mediated effects.</p> <p>MaR-1 significantly improved cell viability and reduced ferroptosis-related markers (ROS, MDA, and iron ion concentration) <i>in vitro</i>. …”
-
10343
Image 1_Different lysine-to-methionine ratios in a low-protein diet affect the microbiome and metabolome, influencing the jejunal barrier function in Tibetan sheep.pdf
Published 2025“…Furthermore, lowering the dietary Lys/ Met ratio significantly increased the abundance of Romboutsia, the Ruminococcus gauvreauii group, the Lachnospiraceae NK3A20 group, Ruminococcus 2, and the Christensenellaceae R-7 group (p < 0.05) while decreasing the abundance of Methanobrevibacter (p < 0.05). …”
-
10344
Table 1_Different lysine-to-methionine ratios in a low-protein diet affect the microbiome and metabolome, influencing the jejunal barrier function in Tibetan sheep.docx
Published 2025“…Furthermore, lowering the dietary Lys/ Met ratio significantly increased the abundance of Romboutsia, the Ruminococcus gauvreauii group, the Lachnospiraceae NK3A20 group, Ruminococcus 2, and the Christensenellaceae R-7 group (p < 0.05) while decreasing the abundance of Methanobrevibacter (p < 0.05). …”
-
10345
Minimum data set used in the article.
Published 2025“…Excessively high C:P reduced soil phosphorus effectiveness. Regarding the soil vertical profile, SOC and TN contents in forestland and grassland both decreased with increasing soil depth, while the three nutrients in cropland soil exhibited more complex vertical variation characteristics. …”
-
10346
Concentrations of C, N, and P in time change.
Published 2025“…Excessively high C:P reduced soil phosphorus effectiveness. Regarding the soil vertical profile, SOC and TN contents in forestland and grassland both decreased with increasing soil depth, while the three nutrients in cropland soil exhibited more complex vertical variation characteristics. …”
-
10347
Table1_Vermicompost application improves leaf physiological activity, 2-acetyl-1-pyrroline, and grain yield of fragrant rice through efficient nitrogen assimilation under Cd stress...
Published 2024“…In addition, VC application significantly (p < 0.05) decreased the Cd uptake and accumulation in rice plants. …”
-
10348
Da-Yuan-Yin decoction suppresses NETs formation, inhibits the IL-23/JAK2/STAT3 signalling pathway, and modulates metabolic profiles and gut microbiota composition in damp-heat synd...
Published 2025“…Complete blood count (CBC), blood biochemistry, short-chain fatty acids (SCFAs), gut microbiota composition in the colon, and metabolites in the cecum were analyzed.</p> <p>DYY significantly reduced symptom scores and decreased CRP level, while also regulating parameters in CBC and biochemical profiles. …”
-
10349
Data Sheet 1_Genetic knockdown of DYRK1A attenuates cognitive impairment, Aβ pathology, tauopathy and neuroinflammatory responses in mouse models of AD.docx
Published 2025“…Introduction<p>Dual specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is associated with the pathoprogression of neurodevelopmental and neurodegenerative disorders. However, the effects of direct genetic manipulation of DYRK1A in the brain on cognitive function, neuroinflammation and Alzheimer’s disease (AD) pathology and underlying molecular mechanisms have not been fully investigated.…”
-
10350
Accommodating talker variability in noise (Zhang & Peng, 2025)
Published 2025“…</p><p dir="ltr"><b>Results: </b>Listeners were able to use context cues to adapt to talker variability in Cantonese tones at SNRs of 0 dB and above. The effectiveness of using context cues decreased as the SNR lowered. …”
-
10351
Data Sheet 1_Improved myocardial mitochondrial energy metabolism in rats with chronic heart failure by modifying fatty acid oxidation using an extract of sand-fired aconite (Jianch...
Published 2025“…</p>Results<p>SFAS significantly improved cardiac function in CHF rats. …”
-
10352
Image 2_A natural PCID2-Targeting compound suppresses hepatocellular carcinoma progression: evidence from structure-based discovery and biological evaluation.jpeg
Published 2025“…Mechanistically, β-PGG decreased PCID2 expression and downregulated Cyclin D1 and CDK6. …”
-
10353
Supplementary file 1_A natural PCID2-Targeting compound suppresses hepatocellular carcinoma progression: evidence from structure-based discovery and biological evaluation.docx
Published 2025“…Mechanistically, β-PGG decreased PCID2 expression and downregulated Cyclin D1 and CDK6. …”
-
10354
Data Sheet 2_Soy-based purified ingredient diet affects mouse gut permeability and the microbiome in fragile X mice.pdf
Published 2025“…Beta-diversity of the cecal microbiome was significantly altered as a function of the four test diets. …”
-
10355
Image 1_A natural PCID2-Targeting compound suppresses hepatocellular carcinoma progression: evidence from structure-based discovery and biological evaluation.png
Published 2025“…Mechanistically, β-PGG decreased PCID2 expression and downregulated Cyclin D1 and CDK6. …”
-
10356
Supporting data for “<b>Human Lipocalin-2 Variants: Therapeutic Evaluations</b>”
Published 2024“…Using transgenic TG-hLcn2/LKO and global lipocalin-2 knockout (LKO) mouse models, we examined the expression of these lipocalin-2 variants during high-fat dietary exposure and assessed their effects on neutrophil lifespan and phenotype.</p><p dir="ltr">Following a high-fat diet, our findings demonstrated that C87A levels were significantly elevated in cardiac and epididymal white adipose tissue (eWAT). …”
-
10357
DataSheet1_DYNLT3 overexpression induces apoptosis and inhibits cell growth and migration via inhibition of the Wnt pathway and EMT in cervical cancer.pdf
Published 2025“…Up-regulation of DYNLT3 expression significantly inhibited tumor growth in a nude mouse model, while downregulation of DYNLT3 showed the opposite results. …”
-
10358
Data Sheet 1_Therapeutic potential of Glycyrrhiza polysaccharides in pseudorabies virus infection: immune modulation, antioxidant activity, and gut microbiota restoration.pdf
Published 2025“…Aim of the study<p>This study aimed to evaluate the protective effects of Glycyrrhiza polysaccharides (GPs) on Pseudorabies virus (PRV)-infected mice and elucidate their mechanisms of action, with a focus on intestinal immunity, oxidative stress, mucosal barrier function, and gut microbiota composition.…”
-
10359
Supplementary Material for: Hemispherotomy for Drug-Resistant Epilepsy in a Low-resource Setting: Surgical Outcomes and Quality of Life in 23 Children Treated in a Hybrid Program i...
Published 2025“…Introduction: Hemispherotomy is an effective treatment for children with drug-resistant epilepsy (DRE). …”
-
10360
Data Sheet 1_Soy-based purified ingredient diet affects mouse gut permeability and the microbiome in fragile X mice.pdf
Published 2025“…Beta-diversity of the cecal microbiome was significantly altered as a function of the four test diets. …”