Supplementary Material for: Efficacy of Spray Cryotherapy on Airway Secretions in Canine Models of Chronic Bronchitis and Mechanism Insights حسب Wang B. (4026758)

"…SCT treatment reduced mucus and pulmonary resistance, improved bronchial structure, and decreased goblet cells. SCT significantly reduced BALF mucin, MUC5AC, MUC5B, acetylcholine, IL-6, INF-γ, TNF-α, and IL-10, and bronchial MUC5AC and CHRM3. …"

DataSheet1_Synergistic combinations of Angelica sinensis for myocardial infarction treatment: network pharmacology and quadratic optimization approach.docx حسب Wen-Di Wang (20400446)

"…Further research revealed that Z-LIG/CGA treatment significantly increased IL-1R2 levels, significantly decreased IL-17RA levels, and inhibited the activation of p-STAT1, thereby alleviating cell apoptosis after MI. …"

Data Sheet 1_Effect of Fangxia-Dihuang Decoction on doxorubicin-induced cognitive impairment in breast cancer animal model.docx حسب Xuan Wang (55634)

"…The results of blood routine and cardiac HE staining showed that compared with the 4T1 group, the serum ALT, AST, CK, LDH, and CKMB in DOX group mice were significantly increased (P<0.05). After FXDH administration, all indicators in mice were decreased, but there was no statistical difference. …"

Raw data DOI 10.3389fphar.2024.1483686.zip حسب Changlin Wang (19822068)

"…In terms of mechanism, JJJG significantly increased the levels of FT3 and FT4 and decreased TSH level in serum (P<0.05). …"

Table1_The interaction between selenium and other elements in soil and rice roots shaped by straw and straw biochar regulated the enrichment of selenium in rice grain.docx حسب Qinlei Rong (3815335)

"…The results showed that the incorporation of straw and straw biochar into the fields increased the content of soil-soluble Se (SOL-Se) but significantly decreased the content of iron-manganese oxide-bound Se (FMO-Se) and organic matter-bound Se (OM-Se). …"

Table 1_Distinct response patterns of endothelial markers to the BNT162b2 mRNA COVID-19 booster vaccine are associated with the spike-specific IgG antibody production.docx حسب Beatriz Castro-Robles (20506802)

"…</p>Results<p>We identified two significantly distinct profiles of endothelial markers response, characterized by either increased or decreased serum levels of endocan and sVCAM. …"

Video 1_Effect of Fangxia-Dihuang Decoction on doxorubicin-induced cognitive impairment in breast cancer animal model.mp4 حسب Xuan Wang (55634)

"…The results of blood routine and cardiac HE staining showed that compared with the 4T1 group, the serum ALT, AST, CK, LDH, and CKMB in DOX group mice were significantly increased (P<0.05). After FXDH administration, all indicators in mice were decreased, but there was no statistical difference. …"

Data Sheet 1_Polydatin combined with hawthorn flavonoids alleviate high fat diet induced atherosclerosis by remodeling the gut microbiota and glycolipid metabolism.pdf حسب Dan Li (106345)

"…</p>Results<p>Polydatin combined with hawthorn flavonoids administration significantly reduced lipid and inflammatory cytokine levels, meanwhile, the atherosclerotic lesions in a high-fat diet-induced ApoE^−/− mice were significantly decreased. …"

Image 1_Yishen-Huoxue formula alleviates renal interstitial fibrosis by attenuating hypoxia-induced renal cell injury and promoting angiogenesis via miR-210/HIF-1α pathway.jpeg حسب Mouying Du (21398510)

"…In vitro experiments revealed that miR-210 downregulates the expression of HIF-1α and its downstream factors, mitigating hypoxia-induced cellular injuries, including decreased cell viability, migration ability, and angiogenesis capability. …"

Data Sheet 1_Global, regional, and national trends and burden of multiple sclerosis in adolescents and young adults: a data analysis from 1990 to 2021 and projections to 2040.zip حسب Peixi Zhao (620068)

"…Background and Objectives<p>Multiple sclerosis (MS) significantly impacts adolescents and young adults (aged 15–39 years), causing substantial neurological disability. …"

Data Sheet 2_Global, regional, and national trends and burden of multiple sclerosis in adolescents and young adults: a data analysis from 1990 to 2021 and projections to 2040.docx حسب Peixi Zhao (620068)

"…Background and Objectives<p>Multiple sclerosis (MS) significantly impacts adolescents and young adults (aged 15–39 years), causing substantial neurological disability. …"

Image 2_Apolipoprotein C1 -317H1/H2 and the rs4420638 genetic variations and risk of gestational diabetes mellitus in Chinese women: a case-control study.jpeg حسب Wandi Ma (17295430)

"…Background<p>Dyslipidemia and oxidative stress are key components in the pathophysiology of gestational diabetes mellitus (GDM), yet the contribution of genetic factors to these metabolic disturbances remains unclear. …"

Image 1_Apolipoprotein C1 -317H1/H2 and the rs4420638 genetic variations and risk of gestational diabetes mellitus in Chinese women: a case-control study.jpeg حسب Wandi Ma (17295430)

"…Background<p>Dyslipidemia and oxidative stress are key components in the pathophysiology of gestational diabetes mellitus (GDM), yet the contribution of genetic factors to these metabolic disturbances remains unclear. …"

Image 2_Yishen-Huoxue formula alleviates renal interstitial fibrosis by attenuating hypoxia-induced renal cell injury and promoting angiogenesis via miR-210/HIF-1α pathway.jpeg حسب Mouying Du (21398510)

"…In vitro experiments revealed that miR-210 downregulates the expression of HIF-1α and its downstream factors, mitigating hypoxia-induced cellular injuries, including decreased cell viability, migration ability, and angiogenesis capability. …"

Image 1_Loss of calcium/calmodulin-dependent protein kinase kinase 2, transferrin, and transferrin receptor proteins in the temporal cortex of Alzheimer’s patients postmortem is as... حسب Mohammad Golam Sabbir (15874493)

"…</p>Results<p>CAMKK2, TF, and TFRC levels were significantly decreased in AD patients’ temporal cortices compared to CN individuals, independent of age or postmortem interval-related changes. …"

Image 2_Loss of calcium/calmodulin-dependent protein kinase kinase 2, transferrin, and transferrin receptor proteins in the temporal cortex of Alzheimer’s patients postmortem is as... حسب Mohammad Golam Sabbir (15874493)

"…</p>Results<p>CAMKK2, TF, and TFRC levels were significantly decreased in AD patients’ temporal cortices compared to CN individuals, independent of age or postmortem interval-related changes. …"

Table 1_Loss of calcium/calmodulin-dependent protein kinase kinase 2, transferrin, and transferrin receptor proteins in the temporal cortex of Alzheimer’s patients postmortem is as... حسب Mohammad Golam Sabbir (15874493)

"…</p>Results<p>CAMKK2, TF, and TFRC levels were significantly decreased in AD patients’ temporal cortices compared to CN individuals, independent of age or postmortem interval-related changes. …"

Image 3_Loss of calcium/calmodulin-dependent protein kinase kinase 2, transferrin, and transferrin receptor proteins in the temporal cortex of Alzheimer’s patients postmortem is as... حسب Mohammad Golam Sabbir (15874493)

"…</p>Results<p>CAMKK2, TF, and TFRC levels were significantly decreased in AD patients’ temporal cortices compared to CN individuals, independent of age or postmortem interval-related changes. …"

Table 4_ESG performance and carbon emission intensity: examining the role of climate policy uncertainty and the digital economy in China’s dual-carbon era.xlsx حسب Shiyu Li (144475)

"…Additionally, it underscores the significance of considering CPU and DE as critical moderating factors in ESG-CEI dynamics, offering insights for policymakers aiming to balance technological advancement with environmental responsibility.…"

Table 6_ESG performance and carbon emission intensity: examining the role of climate policy uncertainty and the digital economy in China’s dual-carbon era.xlsx حسب Shiyu Li (144475)

"…Additionally, it underscores the significance of considering CPU and DE as critical moderating factors in ESG-CEI dynamics, offering insights for policymakers aiming to balance technological advancement with environmental responsibility.…"