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541
Table 1_Digital health management models improve the metabolism, sleep, and gut microbiota in patients with metabolic disorders.docx
Published 2025“…In the DHM group, the CV of fasting blood glucose decreased to 8.4 ± 1.1% (p < 0.001), REE increased by 167 kcal/d (p < 0.001), baPWV decreased by 348.6 cm/s (p < 0.001), the abundance of butyrate-producing bacteria increased 3.1-fold (p < 0.001), and sleep quality scores improved to 93.1 ± 9.3 points (p < 0.001). …”
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542
Genotoxic Mechanisms of Erythrophleum suaveolens Stem Bark Extracts and Fractions in MCF-7 Breast Cancer Cells via Mitochondrial and Non-Mitochondrial Pathways
Published 2025“…After 72 hours, ESSB-treated MCF-7 cells showed a significant (p < 0.05) increase in DNA fragmentation and comet tail DNA percentages (flavonoids induced a 1.21-fold increase in comet tail length). …”
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543
Neural lamella remodeling is needed for macrophage invasion.
Published 2025“…(<b>C</b>) Panglial expression of <i>Pvf2</i> and concomitant knockdown of <i>STAT92E</i> decreases the number of invaded macrophages by ~ 10-fold. …”
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544
HK2 regulates mRNA translation in melanoma cells.
Published 2025“…HK2 depletion significantly decreased the abundance of <i>SOX10</i>, <i>CDH2</i>, and <i>WNT5A</i> mRNAs extracted from polysome fractions, but not in total RNAs. …”
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545
Figure 3 from Synergistic Effects of PARP Inhibition and Cholesterol Biosynthesis Pathway Modulation
Published 2025“…Niraparib decreases CYP51A1 (lanosterol 14α-demethylase) enzyme levels (Supplementary Fig. …”
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546
Design, synthesis and biological evaluation of marine naphthoquinone-naphthol derivatives as potential anticancer agents
Published 2024“…Among these, Compound <b>13</b>, featuring an oxopropyl group at the <i>ortho</i>-position of quinone group, exhibited the most potent inhibitory effects on HCT116, PC9, and A549 cells, with IC<sub>50</sub> values decreasing from 5.27 to 1.18 μM (4.5-fold increase), 6.98 to 0.57 μM (12-fold increase), and 5.88 to 2.25 μM (2.6-fold increase), respectively, compared to compound <b>5</b>. …”
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547
Table 1_TCF3 downregulation alleviates renal fibrosis via PI3K/Akt/mTOR pathway inhibition and autophagy restoration in diabetic nephropathy.docx
Published 2025“…Statistical analyses were performed using one-way ANOVA followed by Tukey’s post-hoc test, with p < 0.05 considered statistically significant.</p>Results<p>We first confirmed that TCF3 expression was significantly elevated in both DN rat kidneys (2.8-fold increase at protein level, p < 0.001) and high glucose-treated HK-2 cells (2.5-fold at protein level, p < 0.001) compared to controls. …”
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548
DataSheet1_Transcriptomic and sugar metabolic analysis reveals molecular mechanisms of peach gummosis in response to Neofusicoccum parvum infection.zip
Published 2024“…Our results revealed that N. parvum infection drastically altered the transcripts of cell wall degradation-related genes, the log<sub>2</sub>Fold change in the transcript level of Prupe.1G088900 encoding xyloglucan endotransglycosylase decreased 2.6-fold, while Prupe.6G075100 encoding expansin increased by 2.58-fold at 12 hpi under N. parvum stress. …”
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549
Table 1_Efficacy and mechanism of cyprosulfamide in alleviating the phytotoxicity of clomazone residue on maize seedling.xlsx
Published 2024“…Additionally, the combination of CSA and Clo reduced MDA levels by 13.4%, increased SOD activity by 9.7% and GST activity by 26.7%, while elevating GSSG content by 31.3% compared to Clo alone, ultimately mitigating oxidative damage in maize plants. qRT-PCR analysis showed that the expression of five P450 genes (CYP72A5, CYP81A4, CYP81Q32, CYP81A9, CYP81A36), nine GST genes (GST30, GST31, GSTIV, GSTVI, GST21, GST7, GST37, GST25, IN2-1), and two UGT genes (UGT76C2, UGT83A1) significantly high increased by 6.74-, 10.27-, 4.98-, 10.56-, 25.67-, 16.70-, 46.92-,7.53-, 5.10-, 238.82-, 143.50-, 4.58-, 31.51-, 39.3-, 4.20-, 10.47-fold after CSA+Clo treatment compared to that in the Clo treatment. …”
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550
Study group background characteristics.
Published 2024“…This ratio was disrupted when blood CD4+ T-cells fell to <50 cells/μL and the CSF WBC count decreased to negligible levels; in this group the CSF:blood HIV-1 RNA ratio decreased nearly 10-fold to an overall ratio of <1:100. …”
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551
Supplementary file 1_Forced intensity-controlled endurance training on a small-animal treadmill machine inducing murine cardiac hypertrophy: insights and comparison to voluntary ru...
Published 2025“…After 8 and 12 weeks of training, the heart weight/tibia length ratio was significantly higher than the control. Cardiomyocyte (CM) cross-sectional areas were enlarged by 1.8-fold and shifted to the increased surface area upon training. …”
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552
Data Sheet 1_Antiviral therapy can effectively suppress irAEs in HBV positive hepatocellular carcinoma treated with ICIs: validation based on multi machine learning.zip
Published 2025“…Models were established using Lasso, RSF (RandomForest), and xgBoost, with ten-fold cross-validation and resampling methods used to ensure model reliability. …”
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553
Figure 2 from Loss of Sorting Nexin 10 Accelerates KRAS-Induced Pancreatic Tumorigenesis
Published 2025“…<p>OE of SNX10 decreased cell proliferation in AsPC1 and HPAF-II PDAC cell lines. …”
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554
Data Sheet 1_Morphological changes of lenticels and their role in gas exchange and sprouting physiology of potato tubers during postharvest storage.docx
Published 2025“…Respiration rate increased five-fold when apical lenticels were blocked, whereas it decreased 30-fold when the apical was the only unblocked section, suggesting differential physiological activity across lenticel locations. …”
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555
Data Sheet 2_Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy.docx
Published 2025“…The levels of pro-inflammatory cytokines in blood were also significantly decreased in shPD-L1 treated mice. Additionally, T cell apoptosis rates in the spleen showed a 2-fold increase in treated mice. …”
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556
Data Sheet 1_Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy.pdf
Published 2025“…The levels of pro-inflammatory cytokines in blood were also significantly decreased in shPD-L1 treated mice. Additionally, T cell apoptosis rates in the spleen showed a 2-fold increase in treated mice. …”
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557
Data Sheet 1_Efficacy and mechanism of cyprosulfamide in alleviating the phytotoxicity of clomazone residue on maize seedling.docx
Published 2024“…Additionally, the combination of CSA and Clo reduced MDA levels by 13.4%, increased SOD activity by 9.7% and GST activity by 26.7%, while elevating GSSG content by 31.3% compared to Clo alone, ultimately mitigating oxidative damage in maize plants. qRT-PCR analysis showed that the expression of five P450 genes (CYP72A5, CYP81A4, CYP81Q32, CYP81A9, CYP81A36), nine GST genes (GST30, GST31, GSTIV, GSTVI, GST21, GST7, GST37, GST25, IN2-1), and two UGT genes (UGT76C2, UGT83A1) significantly high increased by 6.74-, 10.27-, 4.98-, 10.56-, 25.67-, 16.70-, 46.92-,7.53-, 5.10-, 238.82-, 143.50-, 4.58-, 31.51-, 39.3-, 4.20-, 10.47-fold after CSA+Clo treatment compared to that in the Clo treatment. …”
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558
Water Hyacinth as a Renewable Source of Cellulose Nanofibers: Fabrication and Properties of Optically Transparent Nanocomposites
Published 2024“…Moreover, the CNF nanopaper significantly decreased the coefficient of thermal expansion of the acrylic resin from 192.3 to 16.3 ppm K<sup>−1</sup>, which is comparable to that of borosilicate glass. …”
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559
Data Sheet 8_Assessing the disease burden of lower respiratory infections attributable to particulate matter pollution: trends from 1990 to 2021 and projections for 2022-2050.pdf
Published 2025“…Low-SDI regions experienced 23-fold higher mortality (ASMR: 31.28 per 100,000) than high-SDI regions (ASMR: 1.34 per 100,000), with slower improvement rates (EAPC: -3.41% vs -6.76% in high-middle SDI). …”
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560
Data Sheet 5_Assessing the disease burden of lower respiratory infections attributable to particulate matter pollution: trends from 1990 to 2021 and projections for 2022-2050.pdf
Published 2025“…Low-SDI regions experienced 23-fold higher mortality (ASMR: 31.28 per 100,000) than high-SDI regions (ASMR: 1.34 per 100,000), with slower improvement rates (EAPC: -3.41% vs -6.76% in high-middle SDI). …”