STAT3 and MYC enrich at <i>STAT3</i> and <i>ZC3H18</i> promoters while EBNA1 predominantly enriches at the <i>BKRF1</i> (EBNA1) promoter. by Huanzhou Xu (8129922)

ZC3H18 regulates NF-kB components independently of LMP1. by Huanzhou Xu (8129922)

Overview of annotated metabolites. by Yunfei Xu (3156420)

“…Additionally, transcriptome analysis revealed 8049 differentially expressed genes, with 4418 upregulated and 3631 downregulated genes. …”

Primer sequences for target genes. by Yongle Du (3992198)

“…By integrating metabonomics with network pharmacology, we identified core targets of ZJP against myopia and constructed a compound-gene-disease-metabolite network. The expressions of LPCAT1 and CHRNA7 were found to decrease in the LIM group but increase with ZJP treatment, whereas NOS2 expression showed the opposite pattern.…”

ASP protects the AC16 cells from DOX-induced cardiotoxicity via Nrf2 activation. by Xueyang Bai (20550422)

“…<p>(A) Representative images of protein expression detected by Western blot of p-PI3K,p-AKT, AKT, and the Nrf2 downstream signaling pathways in AC16 cells; (B, C) ML385 does not affect PI3K/AKT (n = 3); (D-F) The statistical results show that ML385 significantly represses NRF2 activation, leading to a decrease in its downstream gene expression (n = 3); (G, H) Lipid ROS levels (n = 3); (I, J) Quantitative q-PCR analysis of relative ANP and BNP mRNA expression (n = 3); (K, L) Representative images (Scale bar =  100 μm) and statistical analysis of JC-1 (n = 150); One-way ANOVA (Tukey post-test), means ±  SD. …”

Fig 5 - by Joon Young Park (15256702)

“…Among the three RpoD binding sites upstream of <i>cyoABCDE</i>, only the binding intensity at the site corresponding to the transcription start site (TSS) significantly decreases. Additionally, a significant reduction in RpoD binding is also observed for <i>atpIBEFHAGDC</i>. …”

Reconstruction of RpoS regulon under both control and heat shock conditions. by Joon Young Park (15256702)

“…Majority of RpoS regulon genes were activated by RpoS, and the number of regulon genes were significantly expanded by heat shock. …”

Fig 6 - by Joon Young Park (15256702)

“…(B) RpoD binding events upstream of the phosphotransferase system (PTS) genes under four conditions. The binding intensity of RpoD upstream of <i>ptsG</i> and <i>ptsHI</i> significantly decreases in response to heat shock. …”

Ferroptosis Induction by a New Pyrrole Derivative in Triple Negative Breast Cancer and Colorectal Cancer by Domiziana Masci (4224451)

“…Furthermore, lactoperoxidase, malondialdehyde, and Fe­(II) levels significantly increased in <b>12</b>-treated tissues, whereas superoxide dismutase concentrations decreased. …”

Ferroptosis Induction by a New Pyrrole Derivative in Triple Negative Breast Cancer and Colorectal Cancer by Domiziana Masci (4224451)

“…Furthermore, lactoperoxidase, malondialdehyde, and Fe­(II) levels significantly increased in <b>12</b>-treated tissues, whereas superoxide dismutase concentrations decreased. …”

Gene Name to ID Conversion. by Guolian Wu (21464168)

“…Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed significant involvement of these DEGs in acute inflammatory responses, plasma membrane components, PI3K-Akt signaling, and cytokine interactions. …”

Primer sequence of target gene. by Qin Fu (143723)

“…The contents of reactive oxygen species, malondialdehyde and glutathione peroxidase in the music group had no changes compared with those in the control group, while the contents of reactive oxygen species and malondialdehyde in the noise group were higher than the control and the music groups, and the content of glutathione peroxidase was decreased. Compared with the music group, differently expressed genes analysis also showed that the mRNA expression level of inflammatory genes in the jejunum of the music group’ piglets decreased. …”

Relative expression of hub genes. by Ziyang Liu (242055)

Differential analysis of immune cells in brucellosis and healthy controls. by Xiaoyuan Hu (8085944)

Information of core targets. by Guobing Wang (288885)

“…The difference between the single drug group and the corresponding low dose group was significant (P<0.001). After Hela cells were cultured for 72 h, the mRNA and protein expressions corresponding to EGFR, TNF-α, VEGFA, PI3K, AKT and MDM2 were decreased in the experimental group compared with the control group as confirmed by RT-PCR and Western blot, and the extent of the decrease was more obvious with the increase of the drug concentration, and under the condition of the same drug dosage, the effect of the Baicalein group was more pronounced than that of the Wogonin group, and the effect was more obvious in the two-drug group compared with the single-drug group (P<0.05).…”

Composition of Scutellaria Barbata. by Guobing Wang (288885)

“…The difference between the single drug group and the corresponding low dose group was significant (P<0.001). After Hela cells were cultured for 72 h, the mRNA and protein expressions corresponding to EGFR, TNF-α, VEGFA, PI3K, AKT and MDM2 were decreased in the experimental group compared with the control group as confirmed by RT-PCR and Western blot, and the extent of the decrease was more obvious with the increase of the drug concentration, and under the condition of the same drug dosage, the effect of the Baicalein group was more pronounced than that of the Wogonin group, and the effect was more obvious in the two-drug group compared with the single-drug group (P<0.05).…”

GO function enrichment analysis. by Guobing Wang (288885)

“…The difference between the single drug group and the corresponding low dose group was significant (P<0.001). After Hela cells were cultured for 72 h, the mRNA and protein expressions corresponding to EGFR, TNF-α, VEGFA, PI3K, AKT and MDM2 were decreased in the experimental group compared with the control group as confirmed by RT-PCR and Western blot, and the extent of the decrease was more obvious with the increase of the drug concentration, and under the condition of the same drug dosage, the effect of the Baicalein group was more pronounced than that of the Wogonin group, and the effect was more obvious in the two-drug group compared with the single-drug group (P<0.05).…”

KEGG functional enrichment analysis. by Guobing Wang (288885)

“…The difference between the single drug group and the corresponding low dose group was significant (P<0.001). After Hela cells were cultured for 72 h, the mRNA and protein expressions corresponding to EGFR, TNF-α, VEGFA, PI3K, AKT and MDM2 were decreased in the experimental group compared with the control group as confirmed by RT-PCR and Western blot, and the extent of the decrease was more obvious with the increase of the drug concentration, and under the condition of the same drug dosage, the effect of the Baicalein group was more pronounced than that of the Wogonin group, and the effect was more obvious in the two-drug group compared with the single-drug group (P<0.05).…”

The basic flowchart of analysis in this study. by Jing Wang (6206297)

“…Finally, we discovered that the levels of <i>PDK1</i> expression in AD patients were remarkably upregulated, while <i>FDX1</i> and <i>GLS</i> were significantly decreased using qPCR.</p><p>Conclusion</p><p>This study examined changes in intercellular communication between immune cells in the peripheral blood and identified five novel feature genes associated with cuproptosis in AD patients. …”

The enriched GO terms of the 19 DECAGs. by Jing Wang (6206297)

“…Finally, we discovered that the levels of <i>PDK1</i> expression in AD patients were remarkably upregulated, while <i>FDX1</i> and <i>GLS</i> were significantly decreased using qPCR.</p><p>Conclusion</p><p>This study examined changes in intercellular communication between immune cells in the peripheral blood and identified five novel feature genes associated with cuproptosis in AD patients. …”