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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
significant i » significant _ (Expand Search), significant co (Expand Search), significant 17 (Expand Search)
i decrease » _ decrease (Expand Search), a decrease (Expand Search), _ decreased (Expand Search)
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19561
Data Sheet 6_Age-period-cohort analysis of global, regional, and national trends in laryngeal Cancer among older adults, 1990–2021: insights from the 2021 global burden of disease...
Published 2025“…</p>Results<p>From 1990 to 2021, the global ASIR of laryngeal cancer among older adults decreased from 15.16 to 12.25 per 100,000, with significant shifts in trends observed in 1995, 2002, and 2007. …”
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19562
Image 8_A diaryl urea derivative, SMCl inhibits cell proliferation through the RAS/RAF/MEK/ERK pathway in hepatocellular carcinoma.jpeg
Published 2025“…</p>Results<p>The MTS and colony formation assays demonstrated that SMCl significantly decreased the viability of HCC cells. Western blot analysis demonstrated that SMCl effectively suppressed hepatocellular carcinoma proliferation by markedly inhibiting the RAS/RAF/MEK/ERK signaling pathway, with this inhibitory effect exhibiting both time- and concentration-dependent characteristics. …”
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19563
Source data.zip
Published 2025“…In vivo, melatonin significantly increased MT1R (melatonin receptor 1A) expression in BPA-treated mouse testicular cells and the content of catalase, superoxide dismutase 2, and glutathione, while decreasing the level of malondialdehyde. …”
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19564
Citation patterns of Cochrane Reviews and other systematic reviews: a bibliometric analysis
Published 2025“…From 2008 and forward, the overall number of citations was similar between Cochrane Reviews and other systematic reviews (2018–2022: median difference <b>=</b> 5 [95% CI <b>=</b> 4.9–5.1] in favor of Cochrane Reviews; <i>p</i> = 0.83). …”
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19565
<b>Combination of isobavachalcone and amphotericin B has antifungal effect against </b><b>Cryptococcus neoformans</b><b>and protects host tissue damage by inhibiting ferroptosis</b...
Published 2025“…The results demonstrated that IBC (4 μg/mL) significantly reduced the minimum inhibitory concentration (MIC) of AmB from 1 μg/mL to 0.25 μg/mL, indicating a fourfold increase in potency. …”
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19566
Table3_Maslinic acid induces autophagy and ferroptosis via transcriptomic and metabolomic reprogramming in prostate cancer cells.xlsx
Published 2024“…Further, MA was observed to induce prostate cancer cell autophagy by increasing the expression of p53, p-p53, ULK1, Beclin1, Atg7, and Atg5 and the ratio of LC3-II/I and concurrently decreasing the expression of ERK1/2 and mTOR. …”
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19567
Table2_Maslinic acid induces autophagy and ferroptosis via transcriptomic and metabolomic reprogramming in prostate cancer cells.xlsx
Published 2024“…Further, MA was observed to induce prostate cancer cell autophagy by increasing the expression of p53, p-p53, ULK1, Beclin1, Atg7, and Atg5 and the ratio of LC3-II/I and concurrently decreasing the expression of ERK1/2 and mTOR. …”
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19568
Percent of recording electrodes excited or inhibited by stimulation at different frequencies, amplitudes, and types of electrodes.
Published 2024“…<p>(<b>a</b>) Percent of recording electrodes showing significant high frequency activity increases and decreases for each stimulation frequency for depth and surface stimulation sites. …”
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19569
Table 2_Burden of malaria in the Comoros, 1990–2021: findings from the global burden of disease study 2021.xlsx
Published 2025“…Over the past 32 years, the average annual percentage change (AAPC) in the ASPR was statistically significant at −7.60% (t = −2.68, p < 0.05). Moreover, the annual percentage change (APC) in ASIR and ASPR showed the most significant decline from 2012 to 2015, with APCs of −70.47% (t = −3.01, p < 0.05) and − 66.55% (t = −14.94, p < 0.05), respectively.…”
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19570
Data Sheet 2_Triterpenes in breast cancer: a systematic review of preclinical evidence in rodents.xlsx
Published 2025“…Introduction<p>Breast cancer poses a significant health problem for women worldwide due to late-stage diagnosis, toxicity of standard therapy and drug resistance. …”
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19571
Table 3_An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories: 1990–2021.xlsx
Published 2024“…High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). …”
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19572
Image 11_An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories: 1990–2021.tif
Published 2024“…High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). …”
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19573
Image 12_An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories: 1990–2021.tif
Published 2024“…High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). …”
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19574
Image 8_EEG-based characterization of auditory attention and meditation: an ERP and machine learning approach.png
Published 2025“…</p>Result<p>Examination of eventrelated potentials (ERPs) demonstrated that P300 amplitude showed significant growth when responding to oddball stimuli, which indicates increased attention allocation (p < 0.05). …”
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19575
Table 9_Burden of malaria in the Comoros, 1990–2021: findings from the global burden of disease study 2021.xlsx
Published 2025“…Over the past 32 years, the average annual percentage change (AAPC) in the ASPR was statistically significant at −7.60% (t = −2.68, p < 0.05). Moreover, the annual percentage change (APC) in ASIR and ASPR showed the most significant decline from 2012 to 2015, with APCs of −70.47% (t = −3.01, p < 0.05) and − 66.55% (t = −14.94, p < 0.05), respectively.…”
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19576
Table 10_Burden of malaria in the Comoros, 1990–2021: findings from the global burden of disease study 2021.xlsx
Published 2025“…Over the past 32 years, the average annual percentage change (AAPC) in the ASPR was statistically significant at −7.60% (t = −2.68, p < 0.05). Moreover, the annual percentage change (APC) in ASIR and ASPR showed the most significant decline from 2012 to 2015, with APCs of −70.47% (t = −3.01, p < 0.05) and − 66.55% (t = −14.94, p < 0.05), respectively.…”
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19577
Image 10_An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories: 1990–2021.tif
Published 2024“…High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). …”
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19578
Data Sheet 4_Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway.pdf
Published 2025“…Furthermore, SSA displayed inhibitory effects on tumor growth with minimal toxicity in animal studies, accompanied by activated biomarkers of cellular senescence and decreased expression of p-Akt and p-PI3K.</p>Conclusion<p>Taken together, based on the preliminary results of network analysis and further experimental validation, this study revealed that SSA significantly induced cell cycle arrest and senescence, and the inhibition of ROS-mediated PI3K/Akt pathway may be the potential mechanism in this process.…”
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19579
Table 2_An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories: 1990–2021.xlsx
Published 2025“…High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). …”
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19580
Image 8_An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories: 1990–2021.tif
Published 2024“…High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). …”