Circular plot of the forward (ForMR) and reverse (RevMR) MR analyses with inverse variance weighted (IVW) estimates from the 1^st metabolite set (metabolite ratios). by Ozvan Bocher (13813416)

“…<p>Metabolites having increased levels associated with T2D occurrence are presented in red and the ones with decreased levels in blue. Non-significant metabolites, or metabolites not replicated in the 2^nd metabolite set are colored in grey. …”

GRADE judgements. by Da Huang (1306407)

“…Furthermore, there was no significant difference in the change in resting heart rate (RHR) (MD = 2.04, 95% CI: −2.71–6.78; P = 0.40) between the physical activity group and the control group, but there was a significant difference in the change in maximum heart rate (HR-max) (MD = 6.27, 95% CI: 1.75–10.97, P = 0.007). …”

Basic characteristics of the included studies. by Da Huang (1306407)

“…Furthermore, there was no significant difference in the change in resting heart rate (RHR) (MD = 2.04, 95% CI: −2.71–6.78; P = 0.40) between the physical activity group and the control group, but there was a significant difference in the change in maximum heart rate (HR-max) (MD = 6.27, 95% CI: 1.75–10.97, P = 0.007). …”

The data of meta-analysis. by Da Huang (1306407)

“…Furthermore, there was no significant difference in the change in resting heart rate (RHR) (MD = 2.04, 95% CI: −2.71–6.78; P = 0.40) between the physical activity group and the control group, but there was a significant difference in the change in maximum heart rate (HR-max) (MD = 6.27, 95% CI: 1.75–10.97, P = 0.007). …”

Risk of bias. by Da Huang (1306407)

“…Furthermore, there was no significant difference in the change in resting heart rate (RHR) (MD = 2.04, 95% CI: −2.71–6.78; P = 0.40) between the physical activity group and the control group, but there was a significant difference in the change in maximum heart rate (HR-max) (MD = 6.27, 95% CI: 1.75–10.97, P = 0.007). …”

Overall risk of bias assessment. by Da Huang (1306407)

“…Furthermore, there was no significant difference in the change in resting heart rate (RHR) (MD = 2.04, 95% CI: −2.71–6.78; P = 0.40) between the physical activity group and the control group, but there was a significant difference in the change in maximum heart rate (HR-max) (MD = 6.27, 95% CI: 1.75–10.97, P = 0.007). …”

Funnel plot of VO_2Peak inclusion studies. by Da Huang (1306407)

“…Furthermore, there was no significant difference in the change in resting heart rate (RHR) (MD = 2.04, 95% CI: −2.71–6.78; P = 0.40) between the physical activity group and the control group, but there was a significant difference in the change in maximum heart rate (HR-max) (MD = 6.27, 95% CI: 1.75–10.97, P = 0.007). …”

Analysis of subgroups. by Da Huang (1306407)

“…Furthermore, there was no significant difference in the change in resting heart rate (RHR) (MD = 2.04, 95% CI: −2.71–6.78; P = 0.40) between the physical activity group and the control group, but there was a significant difference in the change in maximum heart rate (HR-max) (MD = 6.27, 95% CI: 1.75–10.97, P = 0.007). …”

Proposed model of how morphological plasticity contributes to echinocandin tolerance acquisition in <i>C. tropicalis</i> clinical isolates. by Yongqin Wu (272012)

“…Throughout this process, intricate alterations occur in the expression of genes (e.g., <i>CHS2</i> and <i>GSC1</i>) associated with the cell wall in both tolerant and non-tolerant strains, with a significant downregulation of genes (e.g., <i>ACE2</i>) related to cell division in the tolerant strains. …”

ExaF contributes to FA homeostasis by lowering the FA concentration. by Zachary T. Hying (21512605)

The lag phase defect is specific to transitions that require the production of FA, and correlates with FA concentration. by Zachary T. Hying (21512605)

The presence of lanthanum minimizes the lag phase and FA imbalance during the transition from formate to MeOH. by Zachary T. Hying (21512605)

Fig S1. by Leonardo Santos (477304)

“…Black arrows indicate the formation of heteroduplexes, which are absent in the controls of uninduced and untransfected cells, as well as in induced but untransfected cells (Ctrl and Ctrl2, respectively). A noticeable decrease in amplicon yield suggests significant modifications following Cas9 cleavage and DNA repair processes. …”

State variable definitions. by Richard Lagos (21087738)

“…Furthermore, the sensitivity index on indicates that a 10% reduction in the average time spent by peri-urban dogs in urban and rural areas could result in a decrease of approximately 1% in In conclusion, including the host mobility factor allows us to observe that, in general, the number of infected in the domestic cycle of the disease increases, i.e., our mathematical model provides valuable information on the impact of host mobility on the transmission and spread of cystic echinococcosis.…”

Circular plot of the forward (ForMR) and reverse (RevMR) MR analyses with inverse variance weighted (IVW) estimates from the 1^st metabolite set (absolute metabolite valu... by Ozvan Bocher (13813416)

“…<p>Metabolites having increased levels associated with T2D occurrence are presented in red and the ones with decreased levels in blue. Non-significant metabolites, or metabolites not replicated in the 2^nd metabolite set are colored in grey. …”

Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α₁‑Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents by Chaoquan Tian (21009122)

“…Compared with <b>Tam</b>, the potency of compound <b>10</b> against α_1A-, α_1B-, and α_1D-AR decreased by 118-fold, 642-fold, and 10,000-fold, respectively. …”

Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α₁‑Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents by Chaoquan Tian (21009122)

“…Compared with <b>Tam</b>, the potency of compound <b>10</b> against α_1A-, α_1B-, and α_1D-AR decreased by 118-fold, 642-fold, and 10,000-fold, respectively. …”

Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α₁‑Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents by Chaoquan Tian (21009122)

“…Compared with <b>Tam</b>, the potency of compound <b>10</b> against α_1A-, α_1B-, and α_1D-AR decreased by 118-fold, 642-fold, and 10,000-fold, respectively. …”

TSA alleviates the induction of inflammatory cytokines in <i>Col4a3</i> KO mice. by Yoon Seok Nam (20678482)

“…<p>(A) The mRNA level of proinflammatory cytokines IL-1β and TGF-β1 was higher in the cochlea of <i>Col4a3</i> KO mice, while IL-6 and TNF-α were significantly increased compared to wild-type (WT) mice. …”

Primer sequences. by Min Young Park (2886017)

“…Mice were fed either a 1.2% or 1.65% phosphorus diet and compared to mice fed a control diet containing 0.6% of phosphorus. …”