Video 1_Muscle-specific Bet1L knockdown induces neuromuscular denervation, motor neuron degeneration, and motor dysfunction in a rat model of familial ALS.mp4 by Adam Eckardt (20573576)

“…Bet1L knockdown decreased motor neuron size in the lumbar spinal cord, which innervated the siRNA-injected hindlimb. …”

Data Sheet 1_Effect of a high dose atorvastatin as adjuvant therapy to mesalamine in attenuating inflammation and symptoms in patients with ulcerative colitis: a randomized control... by Sumaiah J. Alarfaj (12889115)

“…</p>Results<p>Compared to the placebo group (n = 24), the atorvastatin group (n = 23) exhibited a significant decrease in the level of IL-6 (p = 0.001), S1P (p = 0.0001), TNF-α (p = 0.003), NO (p = 0.0001), CRP (p = 0.015), ESR (p = 0.012), PMS (p = 0.013), and fecal calprotectin (p = 0.0003), and improved SF-36 (p = 0.006). …”

Image1_AMPK Activation Alleviates Myocardial Ischemia-Reperfusion Injury by Regulating Drp1-Mediated Mitochondrial Dynamics.TIF by Jingxia Du (8752482)

“…We found that Mdivi-1 significantly improved MMP, inhibited ROS production, reduced the expression of TNF-a, IL-6, IL-1β, Fis1, and Mff, and improved the expression of Mfn1 and Mfn2. …”

Image1_The clinical and genetic aspects of six individuals with GH1 variants and isolated growth hormone deficiency type II.tif by Xiaozhen Huang (5858690)

“…Background<p>Isolated growth hormone deficiency type II (IGHD II) is an autosomal dominant disorder characterized by a GH1 gene variant resulting in a significant reduction in growth hormone (GH) secretion and a subsequent decrease of plasma insulin-like growth factor 1 (IGF-1) levels and eventual growth impairment.…”

Table1_The clinical and genetic aspects of six individuals with GH1 variants and isolated growth hormone deficiency type II.docx by Xiaozhen Huang (5858690)

“…Background<p>Isolated growth hormone deficiency type II (IGHD II) is an autosomal dominant disorder characterized by a GH1 gene variant resulting in a significant reduction in growth hormone (GH) secretion and a subsequent decrease of plasma insulin-like growth factor 1 (IGF-1) levels and eventual growth impairment.…”

Heterotrophic cell growth and dry cell yield of <i>Rhodovulum sulfidophilum</i> in artificial seawater (ASW) based growth medium of different salinities, wherein 100% corresponds t... by Shamitha Rao Morey-Yagi (19779981)

“…Asterisks indicate significant differences between 100% and decreasing concentrations of ASW tested using one-way ANOVA (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0321821#pone.0321821.g001" target="_blank">Figs 1b</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0321821#pone.0321821.g001" target="_blank">1c</a>) or two-way ANOVA (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0321821#pone.0321821.g001" target="_blank">Fig 1a</a>), and the Dunnett’s multiple comparison test (GraphPad Prism 9); * p < 0.05, ** p < 0.01, and *** p < 0.001.…”

miR-155 directly targets the 3′UTR of TRAF3 and STAT1. by Xinyue Zhang (271120)

“…Protein levels of endogenous TRAF3 and STAT1 were analyzed by Western blotting. <b>(F)</b> TRAF3 and STAT1 expression is decreased during the late phase of ALV-J infection. …”

Identification of novel pathogenic mutations in <i>ATP6V0A4</i> associated with distal renal tubular acidosis and analysis of wild-type expression in glomerular disease by Yaru Jiang (17458815)

“…This study investigated the key genes involved in renal tubular acid-base regulation (<i>SLC4A1</i>, <i>ATP6V1B1</i> and <i>ATP6V0A4</i>) through whole exome sequencing (WES) in a clinical cohort. …”

<b><i>Original data for "High risk of soil available silicon deficiency in bamboo forest: Insights from bamboo afforestation chronosequences in the karst region of southwest China"... by Kangning Yan (22751487)

“…Furthermore, aboveground Si content decreased significantly from leaves (10.54–21.45 g kg–1) to branches (3.81–5.61 g kg–1) and culms (1.07–1.98 g kg–1). …”

Supplementary file 1_The action of ginsenoside Rg1 in patients with carotid atherosclerosis: a controlled clinical trial.docx by Xu Fang (450501)

“…Fibroblast growth factor 21 levels differed significantly among the groups (P < 0.05), whereas Lumican and Fibulin-1 levels did not (P > 0.05). …”

Short-term antiretroviral therapy may not correct the dysregulations of plasma virome and cytokines induced by HIV-1 infection by Yingying Ma (3617810)

“…Notably, most dysregulated cytokines were not fully restored by ART, with extremely abnormal levels of IL-10, GM-CSF, VEGF, and eotaxin, and a significantly increased level of plasma I-FABP. Anelloviruses showed significantly negative correlations with other commensal viruses except HPgV-1 but had positive correlations with several anti-inflammatory and Th1 cytokines. …”

Image 1_Behavioral benefits of GSK-3β inhibition and state-dependent microtubule signatures in the Fmr1-KO mouse.jpeg by John Kealy (17399515)

“…We examined behaviors and hippocampal α-tubulin post-translational modifications (PTMs) in Fmr1-KO male mice without and with chronic administration of the GSK-3β inhibitors SB216763 (30 mg/kg, i.p.) and AF3581 (10 mg/kg, i.p.). …”

DataSheet1_Kinetics of endothelin-1 and effect selective ETA antagonism on ETB activation: a mathematical modeling analysis.docx by K. Melissa Hallow (9248960)

“…</p>Results<p>The model confirmed the significant role of ET_B in ET-1 clearance. …”

Increased COX6A2 promotes pancreatic β-cell apoptosis and is suppressed in diabetic GK rats after Roux-en-Y gastric bypass by Xiangchen Kong (9500542)

“…We found that RYGB significantly reduced β-cell apoptosis, accompanied by decreased COX6A2 expression in islets from diabetic Goto-Kakizaki (GK) rats. …”

Table 1_Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics study.docx by Kaylie I. Kirkwood-Donelson (19697360)

“…Our study also found significant decreases in cellular taurine, a natural antioxidant in cells. …”

Image 1_Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics study.pdf by Kaylie I. Kirkwood-Donelson (19697360)

“…Our study also found significant decreases in cellular taurine, a natural antioxidant in cells. …”

Data Sheet 1_Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics study.xlsx by Kaylie I. Kirkwood-Donelson (19697360)

“…Our study also found significant decreases in cellular taurine, a natural antioxidant in cells. …”

<b>Supplementary Fig. 1</b> by Richard Babicz (18865600)

“…Erlotinib treatment significantly decreased phospho-ERK levels at both concentrations (figure 1, left). …”

<b>Supplementary Figure 1</b> by Richard Babicz (18865600)

“…Erlotinib treatment significantly decreased phospho-ERK levels at both concentrations (figure 1, left). …”

Table 2_Lyg1 deficiency aggravated LPS-induced chronic epididymal inflammation and sperm dysfunction in mouse.docx by XueXia Liu (13114949)

“…IVF showed a more significant decrease in fertilization rate in KO mice.…”