Image 1_PLK1 inhibition impairs erythroid differentiation.jpeg by Peijun Jia (11334594)

“…In this study, we utilized an in vitro human umbilical cord blood-derived CD34⁺ cell-based erythroid differentiation system, alongside a murine model, to investigate the impact of PLK1 inhibitors on erythropoiesis. Our results indicate that PLK1 inhibitors, specifically GSK461364 and BI6727, significantly suppress the proliferation of erythroid cells, resulting in G2/M phase cell cycle arrest, increased apoptosis in erythroid cells, and the formation of abnormally nucleated late-stage erythroblasts. …”

DataSheet2_Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.DOCX by Na Wang (193263)

“…</p>Results<p>The forward MR analyses showed no significant association between cathepsins and IBD. …”

Supplementary Material for: The effect of far infrared treatment on changes in biomarkers in the arteriovenous fistula by figshare admin karger (2628495)

“…Regardless of treatment group, four-hours of HD caused a significant decrease in tumor necrosis factor-alpha (-1.30 [-1.70;-1.03] pg/ml , P= <0.001), monocyte chemoattractant protein-1 (-32.50 [-50.50;-8.25] pg/ml, P= <0.001), nitrite, and nitrate (-20.00 [-27.75;-14.00] µmol/L, P= <0.001) as well as asymmetric dimethylarginine(-0.24 [-0.28;-0.18], µmol/L P= <0.001). …”

Table 2_Flammulina velutipes mycorrhizae dietary fiber attenuates the development of obesity via regulating lipid metabolism in high-fat diet-induced obese mice.xlsx by Fengjuan Jia (703605)

“…</p>Methods<p>Herein, we conducted a comprehensive study utilizing HFD-induced C57BL/6J mice as an obesity model to investigate the impact of Fv-DF on liver lipid accumulation.</p>Results<p>The study, which included an evaluation of Fv-DF on a high-fat diet (HFD)-induced obese mice, revealed that Fv-DF supplementation can effectively decrease weight gain, improve serum lipid levels, and reduce fat deposition in adipose tissues. …”

Table2_Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.XLSX by Na Wang (193263)

“…</p>Results<p>The forward MR analyses showed no significant association between cathepsins and IBD. …”

Table 1_Apigenin protects ischemic stroke by regulating intestinal microbiota homeostasis, regulates brain metabolic profile.xlsx by Jinjian Li (1651954)

“…</p>Results<p>The intervention with apigenin resulted in significant alterations in the intestinal flora, characterized by an increase in the abundance of probiotic species and a decrease in harmful flora, alongside notable changes in brain metabolite profiles. …”

Table3_Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.XLSX by Na Wang (193263)

“…</p>Results<p>The forward MR analyses showed no significant association between cathepsins and IBD. …”

Data Sheet 1_Dupilumab treatment has no effect on the nasal microbiome in patients with NSAID-exacerbated respiratory disease: a longitudinal pilot study.pdf by Tina Bartosik (12300785)

“…Here, we investigated the impact of dupilumab treatment on the composition and diversity of the nasal microbiome.…”

Table 1_Techno-economic analysis of ocean iron fertilization.docx by C. Ward (7771667)

“…Additionally, the effect of learning rates on determining prospective costs is shown through a sensitivity analysis to have a less significant impact on the overall costs of deployment and, in turn, future cost reductions when large parameter input uncertainties are present. …”

Table 1_Adjuvant melatonin therapy during exercise prescription in breast cancer survivors on physical and anthropometric parameters, quality of life, and hormonal response. A rand... by Ana M. Celorrio San Miguel (21583961)

“…Finally, testosterone/cortisol ratio decreased in both groups at the end of intervention, but the difference was not statistically significant (p > 0.05).…”

Tropical volcanic eruptions enhance global tropical cyclone geneses by Jiuwei Zhao (8548263)

“…Here, we utilize global </b><b>reanalysis data and high-resolution large ensemble simulations to uncover a robust link </b><b>between TVEs and enhanced global TCGF. We find a significant increase in TCGF over the </b><b>Pacific within two years following strong TVEs, accompanied by an insignificant decrease </b><b>over the South Indian Ocean, leading to a net global TCGF increase. …”

The dataset for Aerosol emission reductions cause post-2011 rapid warming in the northwestern Pacific. by Nan Yang (22539191)

“…These findings provide crucial insights into the climate impacts of anthropogenic aerosol emission reduction, with significant implications for climate policy formulation.…”

Data Sheet 1_Emotional prompting amplifies disinformation generation in AI large language models.docx by Rasita Vinay (21006911)

“…Notably, emotional prompting had a significant impact on disinformation production rates, with models showing higher success rates when prompted with polite language compared to neutral or impolite requests. …”

Datasheet1_Short-term effects of temperature and air pollution on mortality in Norway: a nationwide cohort-based study.docx by Shilpa Rao (280703)

“…We also see that increased air pollution impacts temperature related mortality in winter and summer time.…”

Regression analysis predicting PAEE-tr. by Nils Georg Niederstrasser (7586426)

“…<div><p>Background</p><p>Pain is associated with a decrease in physical activity for most individuals. …”

Sample characteristics. by Nils Georg Niederstrasser (7586426)

“…<div><p>Background</p><p>Pain is associated with a decrease in physical activity for most individuals. …”

Data Sheet 1_Menthacarin, a proprietary combination of peppermint and caraway oil, alters cultured human fecal microbiota composition, resulting in increased SCFA production.pdf by Martin D. Lehner (3350846)

“…The relative abundance of Firmicutes (+13.6 ± 8.6%) and Actinobacteria (+54.9 ± 47.6%) significantly increased, whereas that of Bacteroidetes (−27.7% ± 21.9%) and Proteobacteria (−25.7% ± 12.3%) significantly decreased in the presence of Menthacarin. …”

Data_Sheet_1_Dynamics of urban development patterns on thermal distributions and their implications on water spread areas of Vellore, Tamil Nadu, India.docx by D. R. Manjunath (19748899)

“…Moreover, spatial and time series analyses of WSAs indicated a significant increase in LST. Furthermore, a strong negative correlation was found between WSA and LST, with a 10% decrease in WSA potentially increasing LST by 0.12°C to 0.55°C in surrounding regions. …”

Data Sheet 1_Microbial and molecular signatures for enhanced gut health in pigs fed a diet with spray-dried plasma as functional protein source.docx by Soumya K. Kar (4600924)

“…We report a significant (P < 0.05) decrease in the relative abundance of the Sarcina genera in the small intestine, an effect comparable to pharmaceutical concentrations of zinc oxide (ZnO). …”

Data_Sheet_1_Dynamics of urban development patterns on thermal distributions and their implications on water spread areas of Vellore, Tamil Nadu, India.docx by D. R. Manjunath (19748899)

“…Moreover, spatial and time series analyses of WSAs indicated a significant increase in LST. Furthermore, a strong negative correlation was found between WSA and LST, with a 10% decrease in WSA potentially increasing LST by 0.12°C to 0.55°C in surrounding regions. …”