يعرض 1,021 - 1,040 نتائج من 1,354 نتيجة بحث عن '(( significant decrease decrease ) OR ( significant impairment decrease ))~', وقت الاستعلام: 0.30s تنقيح النتائج
  1. 1021

    Table 5_Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum.xlsx حسب Fuxing Lin (7418234)

    منشور في 2025
    "…Furthermore, nearly all DEGs related to DNA replication were significantly suppressed. Biochemical assays confirmed these observations: Reduced activities of mitochondrial enzymes [malate dehydrogenase (MDH), isocitrate dehydrogenase (IDH), pyruvate dehydrogenase (PDH), and complexes I–V], decreased mitochondrial membrane potential, and diminished ATP content collectively indicated mitochondrial dysfunction. …"
  2. 1022

    Image 1_Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum.tif حسب Fuxing Lin (7418234)

    منشور في 2025
    "…Furthermore, nearly all DEGs related to DNA replication were significantly suppressed. Biochemical assays confirmed these observations: Reduced activities of mitochondrial enzymes [malate dehydrogenase (MDH), isocitrate dehydrogenase (IDH), pyruvate dehydrogenase (PDH), and complexes I–V], decreased mitochondrial membrane potential, and diminished ATP content collectively indicated mitochondrial dysfunction. …"
  3. 1023

    Table 1_The mitochondrial function of peripheral blood cells in cognitive frailty patients.docx حسب Li Qin (205731)

    منشور في 2024
    "…</p>Conclusion<p>Age, lower educational attainment, malnutrition, and depression are significant risk factors for CF. Moreover, mitochondrial dysfunction, characterized by decreased mtDNAcn, impaired respiratory function and increased ROS levels appears to be a critical phenotype of CF.…"
  4. 1024

    Data Sheet 2_Bifidobacterium depletion promotes goiter via gut-thyroid axis: evidence from Mendelian randomization and experimental validation.xlsx حسب Wenyong Liao (21669332)

    منشور في 2025
    "…In goiter rats, 16S rRNA sequencing revealed eight differentially abundant microbial taxa including significantly reduced B. bifidum, accompanied by: (1) impairment of two butyrate synthesis pathways, (2) decreased levels of six SCFAs (including butyrate), (3) impaired thyroid iodine uptake, (4) downregulated NIS expression, and (5) thyroid dysfunction [reduced triiodothyronine (T3), thyroxine (T4), free T3 (FT3), free T4 (FT4) with elevated thyroid-stimulating hormone (TSH)] - all measurements showing statistical significance (p < 0.05).…"
  5. 1025

    Data Sheet 1_Bifidobacterium depletion promotes goiter via gut-thyroid axis: evidence from Mendelian randomization and experimental validation.xls حسب Wenyong Liao (21669332)

    منشور في 2025
    "…In goiter rats, 16S rRNA sequencing revealed eight differentially abundant microbial taxa including significantly reduced B. bifidum, accompanied by: (1) impairment of two butyrate synthesis pathways, (2) decreased levels of six SCFAs (including butyrate), (3) impaired thyroid iodine uptake, (4) downregulated NIS expression, and (5) thyroid dysfunction [reduced triiodothyronine (T3), thyroxine (T4), free T3 (FT3), free T4 (FT4) with elevated thyroid-stimulating hormone (TSH)] - all measurements showing statistical significance (p < 0.05).…"
  6. 1026

    Dupilumab improves sense of smell and clinical outcomes in patients with severe chronic rhinosinusitis with nasal polyps with anosmia حسب Andrew P. Lane (20367704)

    منشور في 2024
    "…<p>Loss of sense of smell is a cardinal symptom of chronic rhinosinusitis with nasal polyps (CRSwNP) and significantly impacts health-related quality-of-life. …"
  7. 1027

    S1_Figure.pdf حسب George Brooks (21579206)

    منشور في 2025
    "…We observed no age-associated changes in coupling efficiency (ADP:O) of mitochondrial reticulum preparations, but respiratory control (RCR) was decreased in older mice. Additionally, older skeletal muscle exhibited subtle yet significant reductions in the expression of proteins functionally related to substrate uptake and oxidation (mMCT1, mPC1, CPT1b, HADH). …"
  8. 1028

    Alcohol perceptions and driving decisions among adolescents: Exploring the role of peer and parental influences in Virginia حسب Asmaa Namoos (21304297)

    منشور في 2025
    "…<p>This study aims to explore the role of peer and parental influences on adolescent driving behaviors, particularly concerning distracted and alcohol-impaired driving, in light of the significant number of road accidents and fatalities involving young drivers.…"
  9. 1029

    Uncovering the mechanistic basis of <i>Rheum palmatum</i> L. (rhubarb) in the treatment of chronic kidney disease: an integrative approach using network pharmacology, molecular doc... حسب Wenjing He (4278625)

    منشور في 2025
    "…Molecular docking confirmed strong binding affinities of rhubarb’s core compounds with key targets such as TNF and IL6, supporting their therapeutic roles.</p> <p>Rhubarb significantly reduces renal impairment, fibrosis, inflammation, and apoptosis through the NF-κB pathway, supporting its traditional use and potential as an adjunct therapy for CKD.…"
  10. 1030

    Image 2_Changes of brain structure and structural covariance networks in Parkinson’s disease with different sides of onset.tif حسب Tianqi Xu (9574329)

    منشور في 2025
    "…The CSA of the right PCUN showed a significant positive correlation with MMSE score in LPD patients. …"
  11. 1031

    Image 1_Changes of brain structure and structural covariance networks in Parkinson’s disease with different sides of onset.tif حسب Tianqi Xu (9574329)

    منشور في 2025
    "…The CSA of the right PCUN showed a significant positive correlation with MMSE score in LPD patients. …"
  12. 1032

    Image 3_Changes of brain structure and structural covariance networks in Parkinson’s disease with different sides of onset.tif حسب Tianqi Xu (9574329)

    منشور في 2025
    "…The CSA of the right PCUN showed a significant positive correlation with MMSE score in LPD patients. …"
  13. 1033

    Data Sheet 1_Sex differences in the reactivity of gastric myoelectrical activity and heart rate variability as putative psychophysiological markers in human pain research.docx حسب Rossitza Draganova (9154951)

    منشور في 2024
    "…</p>Results<p>Acute pain induced significant instability in EGG slow-wave frequency and amplitude, increased tachygastria, and decreased normogastric spectral power, without evidence of sex differences. …"
  14. 1034

    Raw data for hand and arm dysfunction following hemodialysis access placement حسب Kyoungrae Kim (10312460)

    منشور في 2024
    "…RESULTS: Six weeks post-surgery, patients exhibited significant functional decline in the access limb. Postoperative grip strength declined by approximately 15% (P=0.0015), finger pressure decreased by ~30 mmHg (P<0.0001), and the perceived HAD score increased significantly (P=0.0450) compared to the preoperative values. …"
  15. 1035

    Data Sheet 1_Changes of brain structure and structural covariance networks in Parkinson’s disease with different sides of onset.docx حسب Tianqi Xu (9574329)

    منشور في 2025
    "…The CSA of the right PCUN showed a significant positive correlation with MMSE score in LPD patients. …"
  16. 1036

    Table 1_Alleviating occupational stress in Chinese junior high school teachers: the role of mindfulness-based interventions.docx حسب Huimian Bian (19564274)

    منشور في 2025
    "…Introduction<p>Occupational stress is a significant issue among junior high school teachers in China, contributing to negative outcomes such as reduced mental health, impaired coping abilities, and decreased job satisfaction.…"
  17. 1037

    Image 3_Efficacy and safety of tocilizumab in managing cytokine release syndrome after CD19 CAR-T therapy for relapsed or refractory B-cell acute lymphoblastic leukemia.tiff حسب Qianyi Zhou (6196383)

    منشور في 2025
    "…Additionally, 10 patients showed decreased cytokine levels.Importantly, tocilizumab did not impair CAR-T cell expansion or efficacy, nor did it increase the incidence of adverse events.…"
  18. 1038

    Table 1_Efficacy and safety of tocilizumab in managing cytokine release syndrome after CD19 CAR-T therapy for relapsed or refractory B-cell acute lymphoblastic leukemia.docx حسب Qianyi Zhou (6196383)

    منشور في 2025
    "…Additionally, 10 patients showed decreased cytokine levels.Importantly, tocilizumab did not impair CAR-T cell expansion or efficacy, nor did it increase the incidence of adverse events.…"
  19. 1039

    Image 2_Efficacy and safety of tocilizumab in managing cytokine release syndrome after CD19 CAR-T therapy for relapsed or refractory B-cell acute lymphoblastic leukemia.tiff حسب Qianyi Zhou (6196383)

    منشور في 2025
    "…Additionally, 10 patients showed decreased cytokine levels.Importantly, tocilizumab did not impair CAR-T cell expansion or efficacy, nor did it increase the incidence of adverse events.…"
  20. 1040

    Table 2_Efficacy and safety of tocilizumab in managing cytokine release syndrome after CD19 CAR-T therapy for relapsed or refractory B-cell acute lymphoblastic leukemia.doc حسب Qianyi Zhou (6196383)

    منشور في 2025
    "…Additionally, 10 patients showed decreased cytokine levels.Importantly, tocilizumab did not impair CAR-T cell expansion or efficacy, nor did it increase the incidence of adverse events.…"