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significant impairment » significant improvement (Expand Search), significant improvements (Expand Search), significant impact (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
significant impairment » significant improvement (Expand Search), significant improvements (Expand Search), significant impact (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
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1281
Table 3_TSG-6 promotes healing of critical-sized bone defects in mice.xlsx
Published 2025“…Silencing Tnfaip6 significantly impaired osteogenic differentiation, as indicated by reduced alkaline phosphatase activity and downregulation of key osteogenic marker genes. …”
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1282
Data Sheet 2_TSG-6 promotes healing of critical-sized bone defects in mice.pdf
Published 2025“…Silencing Tnfaip6 significantly impaired osteogenic differentiation, as indicated by reduced alkaline phosphatase activity and downregulation of key osteogenic marker genes. …”
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1283
Data Sheet 1_The oncometabolite R-2-hydroxyglutarate inhibits microglial activation via the FTO/NF-κB pathway.docx
Published 2025“…While R-2HG is known to impair CD8+ T-cell function, its specific impact on microglial activation remains unknown. …”
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1284
Table 1_Exogenous myo-inositol enhances drought tolerance in maize seedlings by antioxidant defense, and photosynthetic efficiency.docx
Published 2025“…Introduction<p>Drought stress severely impairs maize (Zea mays L.) production, particularly during the seedling stage.…”
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1285
Raw data WB.pdf
Published 2025“…Moreover, miR-369-3p significantly decreased the release of pro-inflammatory cytokine IL-8. …”
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1286
Table 2_The gut commensal Faecalibacterium hominis attenuates indole—AhR signaling and restores ASD—like behaviors with BTBR mice.xlsx
Published 2025“…<p>Autism spectrum disorders (ASD), a group of neurodevelopmental disorders characterized by the core symptoms of impaired social communication and stereotyped behaviors, is strongly associated with dysregulated microbiota-gut-brain axis. …”
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1287
Supplementary file 2_Immune indicators as predictors of cancer-related fatigue: a risk prediction model in pan-cancer patients.docx
Published 2025“…Background<p>Cancer‐related fatigue (CRF) is a prevalent and multifactorial symptom that significantly impairs the quality of life in cancer patients. …”
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1288
Table 1_The gut commensal Faecalibacterium hominis attenuates indole—AhR signaling and restores ASD—like behaviors with BTBR mice.xlsx
Published 2025“…<p>Autism spectrum disorders (ASD), a group of neurodevelopmental disorders characterized by the core symptoms of impaired social communication and stereotyped behaviors, is strongly associated with dysregulated microbiota-gut-brain axis. …”
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1289
Supplementary file 1_Immune indicators as predictors of cancer-related fatigue: a risk prediction model in pan-cancer patients.docx
Published 2025“…Background<p>Cancer‐related fatigue (CRF) is a prevalent and multifactorial symptom that significantly impairs the quality of life in cancer patients. …”
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1290
Table 1_Case Report: Identification of a novel hemizygous CFAP47 variant in a primary ciliary dyskinesia patient with dual ciliary and flagellar defects.docx
Published 2025“…Experimental validation revealed significantly decreased CFAP47 mRNA levels in the patient’s sperm and the HEK293 cells transfected with mutant plasmid compared to controls, suggesting impaired transcript stability.…”
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1291
Supplementary file 1_The gut commensal Faecalibacterium hominis attenuates indole—AhR signaling and restores ASD—like behaviors with BTBR mice.docx
Published 2025“…<p>Autism spectrum disorders (ASD), a group of neurodevelopmental disorders characterized by the core symptoms of impaired social communication and stereotyped behaviors, is strongly associated with dysregulated microbiota-gut-brain axis. …”
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1292
Data Sheet 1_Reduction of orexin-expressing neurons and a unique sleep phenotype in the Tg-SwDI mouse model of Alzheimer’s disease.pdf
Published 2025“…The apoptotic cell death marker cleaved caspase-3 immunoreactive (Caspase-3-IR) percentage in orexin-IR neurons was significantly higher in Tg-SwDI mice than in WT controls. …”
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1293
Effect of CO<sub>2</sub> injection on asphaltene deposition.
Published 2025“…</p><p>Conclusions/Significance</p><p>Results demonstrate that clay minerals significantly promote CO<sub>2</sub>-induced asphaltene deposition, with the deposition amount in clay-containing crude oil increasing by 37% compared to clay-free systems. …”
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1294
Effect of clay content on IFT.
Published 2025“…</p><p>Conclusions/Significance</p><p>Results demonstrate that clay minerals significantly promote CO<sub>2</sub>-induced asphaltene deposition, with the deposition amount in clay-containing crude oil increasing by 37% compared to clay-free systems. …”
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1295
Data Sheet 1_Susceptibility to and severity of tuberculosis infection in mice depends upon MHC-II-determined level of activation-inhibition balance in CD4 T-cells.pdf
Published 2025“…Impaired TB control was characterized by decreased selection and maintenance of CD4<sup>+</sup> T-cells, their profoundly narrower TCR repertoires, and a disproportionally enlarged neutrophil population. …”
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1296
Effect of clay content on crude oil viscosity.
Published 2025“…</p><p>Conclusions/Significance</p><p>Results demonstrate that clay minerals significantly promote CO<sub>2</sub>-induced asphaltene deposition, with the deposition amount in clay-containing crude oil increasing by 37% compared to clay-free systems. …”
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1297
Effect of pressure on asphaltene deposition.
Published 2025“…</p><p>Conclusions/Significance</p><p>Results demonstrate that clay minerals significantly promote CO<sub>2</sub>-induced asphaltene deposition, with the deposition amount in clay-containing crude oil increasing by 37% compared to clay-free systems. …”
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1298
The quality metrics of 4C-seq data.
Published 2025“…Functional assays demonstrated that targeted repression of Pparα-En4 region significantly decreased <i><i>Ppar</i>α</i> expression and impaired brown adipocyte differentiation and thermogenesis. …”
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1299
<i>Edwardsiella piscicida</i> employs C3 derivative to mediate internalization and infection via the teleost-specific receptor
Published 2025“…When PoCD18 was knocked down or blocked, bacterial infection and tissue lesions were significantly decreased. Mechanistically, the intracellular domain of PoCD18 subsequently interacted with PoCytohesin and triggered the phosphorylation of the phosphatidylinositol 3-kinase (PI3K)/serine-threonine protein kinase (Akt) signalling pathway. …”
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1300
Data Sheet 3_The power of GM-CSF: immune regulation in the defense against Phialophora verrucosa infection.pdf
Published 2025“…</p>Results<p>Compared to WT mice, GM-CSF deficiency significantly delayed fungal clearance and prolonged disease progression, accompanied by reduced inflammatory responses and decreased neutrophil infiltration. …”