Graph illustrating the distribution of mutations across 20 genes. by Ashraf Attia Mahmoud (21262201)

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Molecular dynamics simulation results for Apo-TP53 (red), wild-typeTP53. by Ashraf Attia Mahmoud (21262201)

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Effect of mutations on protein stability predicted by I-MUTANT 2.0, MUpro and CUPSAT. by Ashraf Attia Mahmoud (21262201)

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P53 mutant docking results (HDOCK and pyDOCK servers). by Ashraf Attia Mahmoud (21262201)

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Oncogenic Classification of TP53 missense mutations. by Ashraf Attia Mahmoud (21262201)

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Computational analysis of missense mutations using PhD-SNP, PANTHER and, SNPs&GO. by Ashraf Attia Mahmoud (21262201)

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Redocking results showing the interaction between the TP53 protein (white ribbon) and its DNA dodecamer ligand (magenta and blue) from PDB ID: 2AC0, highlighting the binding confor... by Ashraf Attia Mahmoud (21262201)

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Result of the phenotypic analysis. by Ashraf Attia Mahmoud (21262201)

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Oncogenic nature of mutations predicted using CScape and CScape-somatic. by Ashraf Attia Mahmoud (21262201)

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(A) Pie chart showing the distribution of mutation types identified within the TP53 gene. by Ashraf Attia Mahmoud (21262201)

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Structural clashes in TP53 mutants: (A) G266E mutation causes steric clashes with PHE109 and LEU257, destabilizing the structure. by Ashraf Attia Mahmoud (21262201)

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(A) TP53 expression levels are elevated in TP53-mutant and nonmutant HNSC samples compared to normal tissues. by Ashraf Attia Mahmoud (21262201)

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Type of Mutations. by Ashraf Attia Mahmoud (21262201)

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Table 5_PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment.xlsx by Hong-Xing Li (316258)

“…After down expression of PABPN1, mRNA expression levels of MRPS15 and GPx (Glutathione peroxidase) decreased significantly in T24, 5637 HLF and MCF-7 cells.…”

Image 8_PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment.tif by Hong-Xing Li (316258)

“…After down expression of PABPN1, mRNA expression levels of MRPS15 and GPx (Glutathione peroxidase) decreased significantly in T24, 5637 HLF and MCF-7 cells.…”

Table 2_PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment.xlsx by Hong-Xing Li (316258)

“…After down expression of PABPN1, mRNA expression levels of MRPS15 and GPx (Glutathione peroxidase) decreased significantly in T24, 5637 HLF and MCF-7 cells.…”

Image 3_PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment.tif by Hong-Xing Li (316258)

“…After down expression of PABPN1, mRNA expression levels of MRPS15 and GPx (Glutathione peroxidase) decreased significantly in T24, 5637 HLF and MCF-7 cells.…”

Image 6_PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment.tif by Hong-Xing Li (316258)

“…After down expression of PABPN1, mRNA expression levels of MRPS15 and GPx (Glutathione peroxidase) decreased significantly in T24, 5637 HLF and MCF-7 cells.…”

Image 7_PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment.png by Hong-Xing Li (316258)

“…After down expression of PABPN1, mRNA expression levels of MRPS15 and GPx (Glutathione peroxidase) decreased significantly in T24, 5637 HLF and MCF-7 cells.…”

Table 4_PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment.xlsx by Hong-Xing Li (316258)

“…After down expression of PABPN1, mRNA expression levels of MRPS15 and GPx (Glutathione peroxidase) decreased significantly in T24, 5637 HLF and MCF-7 cells.…”