Supplementary file 1_Case Report: Loss-of-function TRPM4 mutation p.L91Δ implicated in progressive cardiac conduction defect.docx by Anne-Flore Hämmerli (18121647)

“…Functional experiments using the patch-clamp approach demonstrated a significant decrease in TRPM4 current, consistent with the biochemical observations.…”

Untargeted Urinary Proteomics Uncovers Nephroprotective and Systemic Adaptations after Obesity Surgery-Induced Weight Loss by Pedro R. Pereira (6016460)

“…Protein functional classification revealed associations with immune function (<i>n</i> = 17; e.g., protein S100-A9, α-1-acid glycoproteins); cytoskeleton/cell adhesion (<i>n</i> = 11; e.g., supervillin, ezrin, periplakin), and kidney adaptation (<i>n</i> = 11; e.g., elongation factor 1-α 1, megalin, cubilin). A decrease in inflammation protein markers (α-1-acid glycoproteins), alongside an increase in proteins associated with immune modulation and oxidative stress protection (dipeptidase 1, heat shock cognate 71 kDa protein) were observed. …”

<b>Indirect effects of warming via phenology on reproductive success of alpine plants</b> by Tianwu Zhang (13169939)

“…Furthermore, warming led to a decrease in the number of seeds and productivity of alpine plants, while seed size remained stable. …”

Data Sheet 1_Therapeutic effects of traditional Chinese medicine Hua-Feng-Dan in a rat model of ischemic stroke involve renormalization of gut microbiota.docx by Xiaoxia He (459582)

“…It partially reversed stroke-induced intestinal barrier disruption and leakage, inflammation, dyslipidemia and oxidative stress, as well as the stroke-induced increase in pathogenic gut microbiota (e.g., Escherichia-Shigella, Enterococcus, Clostridium_innocuum_group) and decrease in beneficial microbiota (e.g., Lachnospiraceae, unclassified__f__Lachnospiracea and Ruminococcus_torques_group). …”

Table 2_The impact of long-term trends in continuity of care on the medical expenses of hypertensive patients: based on group-based trajectory model.xlsx by Yanqiu Du (6817550)

“…</p>Results<p>Four COCI trajectories were identified: low-level maintenance (52.06%), low-level increase (17.14%), high-level decrease (18.94%), and high-level maintenance (11.87%). …”

Table 1_Therapeutic effects of traditional Chinese medicine Hua-Feng-Dan in a rat model of ischemic stroke involve renormalization of gut microbiota.xlsx by Xiaoxia He (459582)

“…It partially reversed stroke-induced intestinal barrier disruption and leakage, inflammation, dyslipidemia and oxidative stress, as well as the stroke-induced increase in pathogenic gut microbiota (e.g., Escherichia-Shigella, Enterococcus, Clostridium_innocuum_group) and decrease in beneficial microbiota (e.g., Lachnospiraceae, unclassified__f__Lachnospiracea and Ruminococcus_torques_group). …”

DataSheet1_Comparative genomic profiling of CBFs pan-gene family in five yellowhorn cultivars and functional identification of Xg11_CBF11.docx by Juan Wang (115708)

“…The results were as follows: the POD and SOD activities of transgenic lines were significantly higher than those of wild-type lines, indicating Xg11_CBF11 improved the adaptability of A. thaliana to low-temperature; The increase of relative conductivity and malondialdehyde, the decrease of chlorophyll content in transgenic lines were smaller than those of wild-type lines, indicating Xg11_CBF11 enhanced the resistance of A. thaliana to low-temperature stress. …”

Data Sheet 1_Response of microbial structure characteristics and enzyme activity to different altitude.pdf by Qiu-liang Cai (21163841)

“…Overall, fungal richness on the sunny side exhibited a slight decrease, whereas diversity increased with altitude. …”

DataSheet1_Single-cell RNA sequencing uncovers molecular mechanisms of intravenous immunoglobulin plus methylprednisolone in Kawasaki disease: attenuated monocyte-driven inflammati... by Minna Yang (11601433)

“…They can also decrease monocyte counts and repress the expression of S100A12, NLRP3, and genes associated with immune-cell migration in monocytes. …”

Table 1_The impact of long-term trends in continuity of care on the medical expenses of hypertensive patients: based on group-based trajectory model.docx by Yanqiu Du (6817550)

“…</p>Results<p>Four COCI trajectories were identified: low-level maintenance (52.06%), low-level increase (17.14%), high-level decrease (18.94%), and high-level maintenance (11.87%). …”

Supplementary Material for: Safety profile of intravitreal Dexamethasone implant to manage diabetic macular edema: A systematic review of real-world studies. by figshare admin karger (2628495)

“…In general, the peak IOP increase was typically observed 60 days post-DEX-i injection, followed by a decrease in the subsequent months. …”

Table 3_The impact of long-term trends in continuity of care on the medical expenses of hypertensive patients: based on group-based trajectory model.xlsx by Yanqiu Du (6817550)

“…</p>Results<p>Four COCI trajectories were identified: low-level maintenance (52.06%), low-level increase (17.14%), high-level decrease (18.94%), and high-level maintenance (11.87%). …”

Chordoma preclinical models are insensitive to BAF complex inhibitor FHD-286, alone or in combination with gemcitabine by Chordoma Foundation (4391989)

“…Gemcitabine did not significantly increase sensitivity to FHD-286 in CH22 and UM-Chor1. …”

Regioisomeric Engineering for Multicharge and Spin Stabilization in Two-Electron Organic Catholytes by H. T. Katie Chung (20496481)

“…Current approaches are limited to the incorporation of electronic substituents to increase or decrease the overall electron density or bulky substituents to sterically shield reactive sites. …”

Supplementary Material for: Preliminary efficacy, tolerability, and safety analysis of Darolutamide for metastatic castration‑resistant prostate cancer: a single-center, open-label... by Yu J. (3610580)

“…The median time to PSA50 in the Darolutamide group was 1.5 months (95%CI 0.2619- 0.9545), significantly lower than that in the placebo group (3.0 months [95%CI 1.048- 3.818], p= 0.0259); The median time to PSA90 in the experimental group was 4 months (95%CI 0.3094- 1.437), 2 months shorter than that in the placebo group (6.0 months [95%CI 0.6961- 3.232]).With the median follow-up of 6 months, , the median decrease in serum PSA was -81.8% (range -60.4 to -99.9%) in the Darolutamide group and -69.4% (range -50.3 to -89.6%) in the placebo group. …”

Image 4_Neutrophil proteins as potential biomarkers for a sputum-based tuberculosis screening test.tif by Mark Chambers (1845670)

“…</p>Results and discussion<p>Significant increases in all proteins were detectable in sputum from clinic-diagnosed TB participants relative to symptomatic controls. …”

Image 6_Neutrophil proteins as potential biomarkers for a sputum-based tuberculosis screening test.tif by Mark Chambers (1845670)

“…</p>Results and discussion<p>Significant increases in all proteins were detectable in sputum from clinic-diagnosed TB participants relative to symptomatic controls. …”

Image 8_Neutrophil proteins as potential biomarkers for a sputum-based tuberculosis screening test.tif by Mark Chambers (1845670)

“…</p>Results and discussion<p>Significant increases in all proteins were detectable in sputum from clinic-diagnosed TB participants relative to symptomatic controls. …”

Image 3_Neutrophil proteins as potential biomarkers for a sputum-based tuberculosis screening test.tif by Mark Chambers (1845670)

“…</p>Results and discussion<p>Significant increases in all proteins were detectable in sputum from clinic-diagnosed TB participants relative to symptomatic controls. …”

Image 7_Neutrophil proteins as potential biomarkers for a sputum-based tuberculosis screening test.tif by Mark Chambers (1845670)

“…</p>Results and discussion<p>Significant increases in all proteins were detectable in sputum from clinic-diagnosed TB participants relative to symptomatic controls. …”