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significant increases » significant increase (Expand Search), significantly increased (Expand Search), significantly decreased (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
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19981
Image 3_Pharmacological inhibition of the RhoA pathway by melatonin reduces viral replication and proinflammatory response against ZIKV and DENV-4 neuroinfections.tiff
Published 2025“…</p>Results<p>Melatonin treatment significantly reduced ZIKV and DENV-4 replication and the associated inflammatory response in U87-MG cells. …”
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19982
Image 8_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.tif
Published 2025“…Among them, BIN2 and CAPN12 were linked to an increased risk, while genes such as CXXC5 and KLRD1 were associated with decreased risk. …”
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19983
Table 1_Factors influencing net ecosystem carbon change in cold-temperate coniferous forests of the Da Xing’an Mountains: analysis across developmental stages based on stand, struc...
Published 2025“…</p>Results<p>Our findings demonstrate that: (1) Net Ecosystem Carbon Change (NECC) is co-limited by stand characteristics, structural diversity, and environmental factors, with stand characteristics exerting the strongest influence, primarily via direct effects. (2) As stands develop, the impacts of structural diversity (effect increasing from 8.68% to 16.44%) and soil factors (from 8.80% to 10.30%) on productivity intensify. (3) In contrast, the influence of climate (decreasing from 30.40% to 17.67%) and terrain (from 14.55% to 6.28%) diminishes with advancing growth stages.…”
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19984
<b>Type 1 diabetes depends on CD4-driven expression of the transcriptional repressor, </b><b><i>Bcl6</i></b>
Published 2024“…CD4-driven loss of functional BCL6 resulted in significantly reduced GC B cell and Tfh cell numbers in the pancreatic lymph nodes and pancreas at late pre-diabetic intervals. …”
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19985
Image 2_Pharmacological inhibition of the RhoA pathway by melatonin reduces viral replication and proinflammatory response against ZIKV and DENV-4 neuroinfections.tiff
Published 2025“…</p>Results<p>Melatonin treatment significantly reduced ZIKV and DENV-4 replication and the associated inflammatory response in U87-MG cells. …”
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19986
Table 2_Extraction of anthocyanins from purple sweet potato: evaluation of anti-inflammatory effects in a rheumatoid arthritis animal model, mechanistic studies on inflammatory cel...
Published 2025“…</p>Results<p>PSPA significantly reduced joint swelling and structural damage in CIA rats, with the highest dose (40 mg/kg) reducing tissue hyperplasia and inflammatory infiltration. …”
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19987
Table 1_Association between DASH diet and metabolic syndrome in US adults: a cross-sectional study.xlsx
Published 2025“…Objective<p>Metabolic syndrome (MetS) is a global issue increasingly threatening human health and the quality of life. …”
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19988
Shikonin promotes ferroptosis though NSUN2-mediated m<sup>5</sup>C methylation modification of TFRC in acute myelocytic leukemia
Published 2025“…Overexpression of NSUN2 similarly decreased cell viability and increased cell death and ferroptosis, effects that were mitigated upon silencing of TFRC. …”
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19989
Table 3_Extraction of anthocyanins from purple sweet potato: evaluation of anti-inflammatory effects in a rheumatoid arthritis animal model, mechanistic studies on inflammatory cel...
Published 2025“…</p>Results<p>PSPA significantly reduced joint swelling and structural damage in CIA rats, with the highest dose (40 mg/kg) reducing tissue hyperplasia and inflammatory infiltration. …”
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19990
Table 2_Elevated miR-17-5p facilitates mycobacterial immune evasion by targeting MAP3K2 in macrophages.doc
Published 2025“…This resulted in decreased production of inflammatory mediators (TNF-α, IL-6, IL-1β), reduced iNOS and ROS levels, and impaired bacterial clearance.…”
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19991
Data Sheet 1_Effects of low-temperature stress during rice heading stage on carbon and nitrogen allocation in paddy eco-system of northeastern China.docx
Published 2025“…</p>Results and Discussion<p>Low-temperature stress significantly reduced rice grain yield of JN809 (sensitive to low-temperature stress) and J88 (tolerant to low-temperature stress) varieties by 27.6% and 21.4%, respectively, This stress tendency increased C and N accumulation in rice stems and leaves, while concurrently decreasing C and N accumulation in panicles. …”
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19992
Data Sheet 2_Aurantii Fructus extract alleviates DSS-induced colitis in mice via regulating NF-κB and Nrf2/HO-1 signaling pathways and modulating intestinal microbiota.zip
Published 2025“…Concurrently, AFE enhanced antioxidant capacity by increasing glutathione (GSH) levels, decreasing malondialdehyde (MDA), and activating the Nrf2/HO-1 signaling pathway. …”
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19993
Table 1_Interaction with IGF1 overrides ANXA2-mediated anti-inflammatory functions of IGFBP5 in vivo.docx
Published 2025“…Monocytes of adjuvant-induced arthritis rats and RA patients expressed less IGFBP5 than normal controls, but its blood levels increased significantly. Adipocytes secreted large amounts of IGFBP5. …”
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19994
Image 11_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.tif
Published 2025“…Among them, BIN2 and CAPN12 were linked to an increased risk, while genes such as CXXC5 and KLRD1 were associated with decreased risk. …”
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19995
Image 3_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.tif
Published 2025“…Among them, BIN2 and CAPN12 were linked to an increased risk, while genes such as CXXC5 and KLRD1 were associated with decreased risk. …”
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19996
Table 2_Association between DASH diet and metabolic syndrome in US adults: a cross-sectional study.xlsx
Published 2025“…Objective<p>Metabolic syndrome (MetS) is a global issue increasingly threatening human health and the quality of life. …”
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19997
Table 2_Interaction with IGF1 overrides ANXA2-mediated anti-inflammatory functions of IGFBP5 in vivo.xlsx
Published 2025“…Monocytes of adjuvant-induced arthritis rats and RA patients expressed less IGFBP5 than normal controls, but its blood levels increased significantly. Adipocytes secreted large amounts of IGFBP5. …”
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19998
Image1_Neutrophil-activating protein in Bacillus spores inhibits casein allergy via TLR2 signaling.jpeg
Published 2024“…Interleukin-12 and interferon-gamma levels increased, whereas serum CAS-specific IgG1 and IgE levels decreased. …”
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19999
Table 2_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.xlsx
Published 2025“…Among them, BIN2 and CAPN12 were linked to an increased risk, while genes such as CXXC5 and KLRD1 were associated with decreased risk. …”
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20000
Image2_Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model.JPEG
Published 2025“…It also alleviated inflammatory responses, including microglial activation and leukocyte infiltration, relieved the impairment of the brain blood barrier and edema, and reduced neuronal apoptosis, axonal loss, and demyelination induced by EAE. The C16 peptide increased the expressions of pTie-2 and Tie-2, integrin αvβ3, and α5β1 and activated the PI3K/Akt signal pathway but decreased the expression of Rho. …”