Data Sheet 1_Circulating extracellular vesicles and neutrophil extracellular traps contribute to endothelial dysfunction in preeclampsia.pdf by Alex Ramos (16267028)

“…ECs incubated with PE-NETs increased VWF and VCAM-1 and decreased VE-cadherin expression vs. control (4 ± 1.6, 5.9 ± 1.2, and 0.5 ± 0.1, respectively, p < 0.05), and notably increased C5b-9 deposit (7.5 ± 2.9, p < 0.05). …”

Image 1_Different lysine-to-methionine ratios in a low-protein diet affect the microbiome and metabolome, influencing the jejunal barrier function in Tibetan sheep.pdf by Fengshuo Zhang (20641988)

“…Furthermore, lowering the dietary Lys/ Met ratio significantly increased the abundance of Romboutsia, the Ruminococcus gauvreauii group, the Lachnospiraceae NK3A20 group, Ruminococcus 2, and the Christensenellaceae R-7 group (p < 0.05) while decreasing the abundance of Methanobrevibacter (p < 0.05). …”

Table 1_Different lysine-to-methionine ratios in a low-protein diet affect the microbiome and metabolome, influencing the jejunal barrier function in Tibetan sheep.docx by Fengshuo Zhang (20641988)

“…Furthermore, lowering the dietary Lys/ Met ratio significantly increased the abundance of Romboutsia, the Ruminococcus gauvreauii group, the Lachnospiraceae NK3A20 group, Ruminococcus 2, and the Christensenellaceae R-7 group (p < 0.05) while decreasing the abundance of Methanobrevibacter (p < 0.05). …”

Image 3_Tetramethylpyrazine attenuates the blood-brain barrier damage against ischemic stroke by targeting endothelin-1/Akt pathway in astrocytes.tif by Minzhen Deng (11267109)

“…Tetramethylpyrazine (TMP), a component of the Chinese medicine, was identified as a potential therapeutic agent. It significantly increased cell viability, reduced ET-1 expression, and mitigated OGD-induced astrocyte damage, as shown by in vitro experiments with ET-1 siRNA and cell lines overexpressing ET-1. …”

Image 2_Tetramethylpyrazine attenuates the blood-brain barrier damage against ischemic stroke by targeting endothelin-1/Akt pathway in astrocytes.tif by Minzhen Deng (11267109)

“…Tetramethylpyrazine (TMP), a component of the Chinese medicine, was identified as a potential therapeutic agent. It significantly increased cell viability, reduced ET-1 expression, and mitigated OGD-induced astrocyte damage, as shown by in vitro experiments with ET-1 siRNA and cell lines overexpressing ET-1. …”

Data Sheet 1_Pinostilbene inhibits lung epithelial-mesenchymal transition and delays pulmonary fibrosis by modulating the PI3K/Akt pathway.docx by Xin Yu (124814)

“…Cellular experiments using A549 and Beas2B cells showed that PIN significantly reduced TGF-β1-induced mesenchymal marker expression while increasing epithelial marker expression. …”

Image 1_Tetramethylpyrazine attenuates the blood-brain barrier damage against ischemic stroke by targeting endothelin-1/Akt pathway in astrocytes.tif by Minzhen Deng (11267109)

“…Tetramethylpyrazine (TMP), a component of the Chinese medicine, was identified as a potential therapeutic agent. It significantly increased cell viability, reduced ET-1 expression, and mitigated OGD-induced astrocyte damage, as shown by in vitro experiments with ET-1 siRNA and cell lines overexpressing ET-1. …”

Unraveling Microplastic Effects on Gut Microbiota across Various Animals Using Machine Learning by Lingzi Yin (20477620)

“…Our study revealed that mice, compared with other animals, not only exhibit a heightened susceptibility to the toxic effects of microplasticsevidenced by decreased gut microbiota diversity, increased <i>Firmicutes</i>/<i>Bacteroidetes</i> ratios, destabilized microbial networks, and disruption in the equilibrium of beneficial and harmful bacteriabut also possess limited potential to degrade microplastics, unlike earthworms and insects. …”

Supplementary Material for: The effectiveness of regionalization of perinatal care and specific facility-based interventions: A systematic review by Ali A.A. (19754238)

“…Results: Implementation of regionalization programs significantly decreased maternal and perinatal mortality. …”

Data Sheet 1_The gastric microbiome altered by A4GNT deficiency in mice.zip by Dawei Gong (3070773)

“…The relative abundance of mutagenic Desulfovibrio and proinflammatory Prevotellamassilia in these mice was significantly increased, especially 4 weeks after birth. …”

Dataset visualization diagram. by Yaojun Zhang (389482)

“…Results on a specialized dataset reveal that YOLOv8n-BWG outperforms YOLOv8n by increasing the mean Average Precision (mAP) by 4.2%, boosting recognition speed by 21.3% per second, and decreasing both the number of floating-point operations (FLOPs) by 28.9% and model size by 26.3%. …”

Astaxanthin mediated repair of tBHP-Induced cellular injury in chondrocytes by Wenwei Liang (9286389)

“…In the osteoarthritis mouse model, they effectively decreased joint inflammation and increased the expression of chondrocyte markers.…”

The effect of G83R mutation on transthyretin protein structural stability by Xingwang Chen (11225802)

“…Molecular dynamics simulation suggested that the G83R mutation reduces the dynamic stability of TTR by increasing the molecule flexibility. In the thermodynamic stability, the quaternary and tertiary structural stability of TTR G83R is lower than wild-type TTR but significantly higher than TTR V30M. …”

Data Sheet 1_Cellular respiration and amino acid metabolism is altered by dietary oligosaccharides in Salmonella with epithelial cell association.docx by Claire A. Shaw (22382332)

“…However, gene expression analysis revealed significantly induced expression of Specific Pathogenicity Island (SPI) 1 (adj. p < 2.0−6) and 2 (adj. p < 3.0−5) with HMO treatment, opposed to increased fimbriae expression (adj.p < 3.0−3) with MOS treatment. …”

Data Sheet 1_A glycogen derived from sea urchin-Strongylocentyotus internedius shifts macrophages to the M1 phenotype and enhances the anti-pancreatic cancer activity of gemcitabin... by Zhenzhen Deng (3707608)

“…MSGA-induced M1 macrophages decreased the cell viabilities and induced apoptosis of PDAC cells. …”

Dataset sample images. by Yaojun Zhang (389482)

“…Results on a specialized dataset reveal that YOLOv8n-BWG outperforms YOLOv8n by increasing the mean Average Precision (mAP) by 4.2%, boosting recognition speed by 21.3% per second, and decreasing both the number of floating-point operations (FLOPs) by 28.9% and model size by 26.3%. …”

Performance comparison of different models. by Yaojun Zhang (389482)

“…Results on a specialized dataset reveal that YOLOv8n-BWG outperforms YOLOv8n by increasing the mean Average Precision (mAP) by 4.2%, boosting recognition speed by 21.3% per second, and decreasing both the number of floating-point operations (FLOPs) by 28.9% and model size by 26.3%. …”

Table 1_Microbial community and flavor analyses of fermented grains of Furou-type Baijiu.docx by Yanyan Tang (250904)

“…The dominant bacterial species changed from Bacillus subtilis to Acetilactobacillus jinshanensis, and the dominant fungal genus, Saccharomyces sp., gradually increased. The relative abundance of Wickerhamomyces anomalus gradually decreased. …”

Data_Sheet_1_Responses of diazotrophic network structure and community diversity to alfalfa-maize intercropping are soil property-dependent.docx by Jinglei Zhang (311803)

“…However, in the average soil, it was the A/M system that had an altered diazotrophic structure, with an increased abundance of 11 bacterial genera and a decreased abundance of three bacterial genera (p < 0.05).…”

Data Sheet 1_Endothelial Zmiz1 modulates developmental angiogenesis in the retina.pdf by Nehal R. Patel (18522672)

“…Inducible endothelial cell-specific ablation of Zmiz1 postnatally resulted in impaired retinal vascular outgrowth, decreased vascular density, and increased vessel regression. …”