Supplementary file 1_Burden of ageing spectrum of diseases in China, 1990–2021: a systematic analysis of global burden of disease study 2021.pdf by Li Yang (6520)

“…However, the number of DALYs attributed to population ageing among people aged 65 and older has been increasing by 10.45 million. Chronic obstructive pulmonary disease, stroke, and ischemic heart disease are most significantly affected by the aging trend. …”

Data Sheet 1_The CaSBP11 gene functions as a negative regulator in pepper drought stress.doc by Huai-Xia Zhang (8493453)

“…Conversely, overexpression of CaSBP11 in Nicotiana benthamiana decreased drought tolerance, with CaSBP11-overexpressing plants showing reduced ABA sensitivity, lower stomatal aperture and ABA levels, and increased stomatal density and ROS production compared to wild-type plants. …”

Image 1_Impact of social factors and health campaigns on the burden of idiopathic epilepsy: an inequality, decomposition, generalized and synthetic difference-in-differences study.... by Xuewen Rong (6242657)

“…The slope index of inequality for the mortality burden decreased from 1.97 to 1.62. After the policy shock, the age-standardized rate (ASR) of years lived with disability (YLD) in the Caribbean increased significantly to 4.59 (95% CI: 0.96 to 8.22), while the all-age YLD rate in the U.S. increased (5.18, 95% CI: 0.66 to 9.70) for both sexes.…”

Table 1_Predicting psychiatric risk: IgG N-glycosylation traits as biomarkers for mental health.xls by Yinchun Lv (18181816)

“…</p>Results<p>In the Psychiatric Genomics Consortium (PGC) database, genetically predicted IGP7 showed a protective role in schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP), while elevated IGP34, and IGP57 increased SCZ risk. High levels of IGP21 were associated with an increased risk of post-traumatic stress disorder (PTSD), while elevated levels of IGP22 exhibited a causal association with a decreased risk of attention-deficit/hyperactivity disorder (ADHD). …”

Rheological investigations of fresh fiber-reinforced cementitious composites using hydrophobic/hydrophilic UHMWPE fibers for 3D concrete printing evaluation by Yan Sun (22436)

“…Hydrophilic fibers significantly enhanced microstructural rigidity, followed by hydrophobic fibers and nanoclay, evidenced through an increase of storage modulus by 115.29%, 59.37%, and 49.49%, respectively. …”

Image 4_Impact of social factors and health campaigns on the burden of idiopathic epilepsy: an inequality, decomposition, generalized and synthetic difference-in-differences study.... by Xuewen Rong (6242657)

“…The slope index of inequality for the mortality burden decreased from 1.97 to 1.62. After the policy shock, the age-standardized rate (ASR) of years lived with disability (YLD) in the Caribbean increased significantly to 4.59 (95% CI: 0.96 to 8.22), while the all-age YLD rate in the U.S. increased (5.18, 95% CI: 0.66 to 9.70) for both sexes.…”

Table 1_Microwave ablation triggers OX40L-mediated disruption of TNFRSF4+ Treg immunosuppressive activity.docx by Runqi Guo (22481293)

“…In vivo, MWA reshaped the tumor microenvironment by significantly increasing the intratumoral CD8+/Treg ratio (P<0.001), indicating a shift toward an anti-tumor inflammatory state. …”

Data Sheet 3_Exposure to deltamethrin leads to gill liver damage, oxidative stress, inflammation, and metabolic disorders of Japanese flounder (Paralichthys olivaceus).pdf by Bingbu Li (21097373)

“…Lysozyme enzyme activity increased, whereas catalase and alkaline phosphatase enzyme activities decreased. …”

<b>Astragalus polysaccharide and </b><b><i>Clostridium butyricum</i></b><b> synergistically inhibit bone loss in mice with humanized intestinal flora</b> by Hongtao Zhang (20774453)

“…Specific mechanisms included that APS-CB increased the amount of short-chain fatty acids, especially butyric acid, in mouse feces, while increasing the abundance of Bacillariophyta (<i>Akkermansia</i>) in the intestine and decreasing the serum level of the bone resorption marker CTX-1. …”

Data Sheet 1_Exposure to deltamethrin leads to gill liver damage, oxidative stress, inflammation, and metabolic disorders of Japanese flounder (Paralichthys olivaceus).pdf by Bingbu Li (21097373)

“…Lysozyme enzyme activity increased, whereas catalase and alkaline phosphatase enzyme activities decreased. …”

RNA quality photo by zahra seifi (20804762)

“…Moreover, although the expression of the GRP78 gene increased in the sinus tissue of diabetic patients with mucormycosis, it significantly decreased in the same patients after treatment. …”

Supplementary Material for: Global, regional, and national burden of motor neuron disease: a systematic analysis of prevalence, incidence, deaths, and DALYs with projections to 203... by figshare admin karger (2628495)

“…Results: From 1990 to 2021, the global number of MND cases, deaths, and DALYs increased significantly, while the age - standardized prevalence and incidence rates decreased. …”

Data Sheet 1_Total flavonoids isolated from Eucommia ulmoides can alleviate bone loss and regulate intestinal microbiota in ovariectomized rats.docx by Baocang Yin (20689031)

“…</p>Results<p>Oral administration of TFEL for 13 weeks increased the serum level of bone formation marker PINP and decreased the level of bone resorption marker NTX-I. …”

Data Sheet 1_Polydopamine nanoparticles as immunomodulators: inhibition of M1 microglial polarization.docx by Maria Cristina Ceccarelli (19233688)

“…To mimic neuroinflammatory conditions, HMC3 cells were stimulated with interferon-gamma (IFN-γ), which significantly increased intracellular ROS levels, surface expression of CD40 and CD86, and secretion of pro-inflammatory cytokines. …”

Table 1_Effects of biochar on phosphorus fraction, phosphatase activity, and phosphorus-solubilizing bacterial abundance: a phosphorus-depleted biochar design.docx by Hongyi Qin (5943515)

“…Acid phosphatase activity was inhibited by PDB in upland soils (a peach orchard, a tea plantation, and a vegetable field). phoD-based sequencing indicated an increased relative abundance of dominant PSB genera in upland soils but a decreased abundance in paddy soils under PDB treatment. …”

DataSheet1_Effect of copper on nitrogen uptake, transportation, assimilation processes, and related gene expression in Chinese cabbage [Brassica campestris L. ssp. Chinensis (L.)]... by Xin Wen (470639)

“…Additionally, Cu treatment decreased nitrate and free amino acid contents, as well as the expression of nitrate transporters NRT1.1 and NRT2.1 in roots while increasing these four parameters in shoots. …”

Data Sheet 1_Silencing ATF3 mediates mitochondrial homeostasis and improves ischemic stroke through regulating the MAPK signaling pathway.docx by Haifengqing Li (21575201)

“…Notably, silencing ATF3 significantly inhibited the production of reactive oxygen species (ROS), increased the concentrations of ATP and NAD+, and upregulated the expression of MFN1 and MFN2. …”

Image 1_Knockdown ATG5 gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation.jpeg by Ai-Li Xu (20622440)

“…DOX–treated mice exhibited decreased heart function and cardiomyocyte size and increased cardiac fibrosis, oxidative stress, and apoptosis. …”

Table 2_Neonatal supplementation of oleamide during suckling ameliorates maternal postpartum sleep interruption-induced neural impairment and endocannabinoid dysfunction in early a... by Linxi Qian (555385)

“…MSI also decreased neurogenesis markers and increased neuroinflammatory markers in the hippocampus. …”

Table 1_Optimization of drying parameters and texture properties of winter jujube slices by radio frequency combined with hot air.xlsx by Yang Li (7082)

“…The VC content of winter jujube slices increased and then decreased with the increase in the three factors. (2) In the orthogonal test, the order of influence of each factor on the quality of the winter jujube tablet is plate spacing > RF interval time > RF application time. …”