Image 7_Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways.tiff حسب Ayaka Goto (20858771)

"…</p>Results<p>Cathepsins B and L were secreted in their precursor forms from HGFs, with significantly elevated protein levels observed at 24, 48, and 72 h post-IL-6/sIL-6R stimulation. …"

Image 9_Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways.tiff حسب Ayaka Goto (20858771)

"…</p>Results<p>Cathepsins B and L were secreted in their precursor forms from HGFs, with significantly elevated protein levels observed at 24, 48, and 72 h post-IL-6/sIL-6R stimulation. …"

Image 8_Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways.tiff حسب Ayaka Goto (20858771)

"…</p>Results<p>Cathepsins B and L were secreted in their precursor forms from HGFs, with significantly elevated protein levels observed at 24, 48, and 72 h post-IL-6/sIL-6R stimulation. …"

Image 2_Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways.tiff حسب Ayaka Goto (20858771)

"…</p>Results<p>Cathepsins B and L were secreted in their precursor forms from HGFs, with significantly elevated protein levels observed at 24, 48, and 72 h post-IL-6/sIL-6R stimulation. …"

Table 4_Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage.xls حسب Xue Li (285380)

"…Tyrosine hydroxylase positive neurons were labeled with immunofluorescence, and tyrosine hydroxylase levels were detected by Western blot (WB) assay.</p>Results<p>Low-dose co-DR1/2I significantly increased MAO-B and ROS levels (p < 0.01) and decreased SOD activity (p < 0.01) in the substantia nigra, striatum, and hippocampus. …"

Table 2_Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage.xls حسب Xue Li (285380)

"…Tyrosine hydroxylase positive neurons were labeled with immunofluorescence, and tyrosine hydroxylase levels were detected by Western blot (WB) assay.</p>Results<p>Low-dose co-DR1/2I significantly increased MAO-B and ROS levels (p < 0.01) and decreased SOD activity (p < 0.01) in the substantia nigra, striatum, and hippocampus. …"

Data Sheet 2_Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage.zip حسب Xue Li (285380)

"…Tyrosine hydroxylase positive neurons were labeled with immunofluorescence, and tyrosine hydroxylase levels were detected by Western blot (WB) assay.</p>Results<p>Low-dose co-DR1/2I significantly increased MAO-B and ROS levels (p < 0.01) and decreased SOD activity (p < 0.01) in the substantia nigra, striatum, and hippocampus. …"

Video 1_Kininogen enhances seizure susceptibility in mice possibly through bradykinin-induced modulation of calcium transients in glutamatergic and GABAergic neurons.mp4 حسب Arijit Ghosh (1304952)

"…</p>Results<p>While scRNA-seq analyses found kininogen gene expressions in various cell types across the brain, immunofluorescence revealed its preferential localization in neurons but not in glia. Pilo-SE decreased intact kininogen levels in the hippocampus and increased cleaved to intact kininogen (cHK / iHK) ratio. …"

Table 5_Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage.xls حسب Xue Li (285380)

"…Tyrosine hydroxylase positive neurons were labeled with immunofluorescence, and tyrosine hydroxylase levels were detected by Western blot (WB) assay.</p>Results<p>Low-dose co-DR1/2I significantly increased MAO-B and ROS levels (p < 0.01) and decreased SOD activity (p < 0.01) in the substantia nigra, striatum, and hippocampus. …"

Image 5_Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways.tiff حسب Ayaka Goto (20858771)

"…</p>Results<p>Cathepsins B and L were secreted in their precursor forms from HGFs, with significantly elevated protein levels observed at 24, 48, and 72 h post-IL-6/sIL-6R stimulation. …"

Comparisons of separability and variance of evidence distributions when noise and variability are manipulated independently for the 4-layer CNN across the three experiments. حسب Medha Shekhar (19502698)

"…On the other hand, separability of evidence distributions decreased significantly from the low to high variability condition and the variance of evidence distribution increased from the low to high variability conditions for all experiments.…"

Genomic DNA yield and integrity obtained from MDR-TB and DS-TB isolate cultures. حسب Linzy Elton (9750221)

"…A) DNA yields extracted from MGIT tubes over time; there was no change in MDR-TB DNA yield, but the DS-TB isolate yield decreased. B) DNA amounts extracted from 7H11 slopes over time; there was no change in MDR-TB DNA yields, but DS-TB isolate yields decreased. …"

Cardiovascular safety of Janus kinase inhibitors in inflammatory bowel disease: a systematic review and network meta-analysis حسب Huibin Yang (10486204)

"…</p> <p>Although a trend of increased cardiovascular risks was found considering dose, no significantly increased cardiovascular risk was associated with JAKinibs in IBD patients, and Deucravacitinib significantly decreased the risks of VTE and CVE.…"

Betulinic acid protects SH-SY5Y cells exposed to lipopolysaccharide and ferrous sulfate through p38MAPK/NF-κB/GPX4/Nrf2/keap-1/HO-1 signaling axis حسب Shivam Kumar Pandey (22295532)

"…Exposure to LPS and FeSO₄ increased the DMT1, Bax, caspase-3, and alpha-synuclein, and decreased the GPX4, FTH1, SLC7A11, Nrf2, Keap1, HO-1, PARK7, Bcl-2, NeuN, and TH levels, resulting in cell ferroptosis, apoptosis, and dopaminergic cell death. …"

Data Sheet 1_Leaf hydraulic decline coordinates stomatal and photosynthetic limitations through anatomical adjustments under drought stress in cotton.docx حسب Xiuli Li (133764)

"…By day 28 after drought stress, drought stress significantly impaired leaf hydraulics, as demonstrated by decreases in leaf hydraulic conductivity (K_leaf) (9.81% under MD, 12.93% under SD) and leaf water potential (5.79% under MD, 17.54% under SD). …"

Data Sheet 1_Dynamics of soil nutrients and biological activities along an infection chronosequence of pine wilt disease in subtropical Masson pine forests.docx حسب Xueyu Song (3600464)

"…The results revealed that soil non-capillary porosity, clay, microbial biomass carbon and microbial biomass nitrogen decreased significantly in 6 years forests. Available potassium consistently decreased with longer invasion periods, while soil polyphenol oxidase, leucine amino peptidase, and available phosphorous peaked in 6 years forests and then declined over time. …"

Exploratory investigation on conversion behaviors and coking tendency during coal-based asphaltene hydrogenation processes حسب Yuanlin Zhang (1694080)

"…And moreover, with hydrogen pressure increases from 2MPa to 4MPa, oil yield increases from 65.28% to 71.16% while coke yield decreases significantly from 8.85% to 2.90%, which indicates that relatively increase hydrogen pressure can effectively stabilize the free radicals to produce oil and restrict the generation of coke at 470°C. …"

Data Sheet 1_Genetic variation in RYR1 is associated with heart failure progression and mortality in a diverse patient population.docx حسب Leonardo A. Guerra (20762270)

"…Based on eQTL data, these SNPs were associated with decreased RYR1 expression in vascular tissue. Two missense variants, in linkage disequilibrium with rs2915950 (rs2915952 and rs2071089) were significantly associated with decreased mortality risk (P = 0.03) and decreased risk of atrial fibrillation/flutter (OR: 0.66, 95% CI: 0.44–0.96; P = 0.03 and OR: 0.67, 95% CI: 0.45–0.98; P = 0.04, respectively). …"

<b>The Global Burden of </b><b><i>Klebsiella pneumoniae</i></b><b>-Associated Lower Respiratory Infection in 204 Countries and Territories, 1990–2021: Findings From the Global Burd... حسب Kaizhi XU (20895128)

"…The global burden of LRI due to <i>Klebsiella pneumoniae</i> significantly decreased over the study period, but lower SDI regions, children, and the elderly remain vulnerable and require targeted interventions to further reduce this burden.…"

Box plot of queens and males in the young colony (left) and old colony (right) A-B compares the queens and males distribution in the young and old colonies, respectively. حسب Moïse Pierre Exélis (21578515)

"…However, in the old colony, the median number of queens is approximately 2.5 times higher than in the young colony, while the number of males has decreased significantly.</p>…"