Determinants of lipid lowering therapy intensification in very high risk patients with dyslipidaemia eligible for PCSK9 monoclonal antibodies: 1-year outcomes of the PERI-DYS study by Klaus G. Parhofer (12280424)

“…</p> <p>Among 1565 patients, LDL-C levels decreased from 91.0 mg/dL at baseline to 73.5 mg/dL at 6 months and 71.5 mg/dL at 12 months. …”

Image 2_Interleukin-26 expression in tuberculosis disease and its regulatory effect in macrophage polarization and intracellular elimination of Mycobacterium tuberculosis.jpeg by Kaisong Huang (5412626)

“…Conversely, circulating IL-26 levels in the plasma of adult TB patients were markedly lower than those of healthy cohorts. …”

Table 1_Cholesterol metabolic reprogramming drives the onset of DLBCL and represents a promising therapeutic target.docx by Lili Zhou (265076)

“…</p>Results<p>We confirmed significant alterations in metabolic markers (such as TC and ApoA1) between the healthy control group and patients, which were significantly associated with patient prognosis and overall OS. …”

Evaluating the effectiveness of safety countermeasures at highway–railway grade crossing based on a machine learning framework by Mohammadali Zayandehroodi (19746176)

“…</p> <p>XGBoost successfully identified 20 important collision and inventory factors with importance levels exceeding 94%, such as the number of daily trains and the surface material. …”

Model inputs. by Natalia Serpetti (5260715)

“…The spatial/temporal model successfully simulated the overall ongoing declining dynamics of the Black Sea ecosystem as the biomasses of the majority of the functional groups had significant observed decreasing trends during the simulation period. …”

Table 1_Trends in the burden of chronic diseases attributable to diet-related risk factors from 1990 to 2021 and the global projections through 2030: a population-based study.docx by Huan Ma (713125)

“…In low-SDI regions, diets low in vegetables showed the strongest association with neoplasm-related mortality, while diets low in fruits were significantly linked to CVD and diabetes burden. High-sodium diet was a significant risk factor for CVD in the middle-SDI regions. …”

Table 1_Association of cardiorespiratory fitness with phenotypic age in younger population: a study based on the NHANES database.docx by Yi Shen (152956)

“…</p>Results<p>In the multivariable logistical regression analysis, maintenance of CRF was significantly and inversely associated with PAA, demonstrating a decreased risk of 42% in the high CRF group [OR (95% CI): 0.58 (0.36, 0.96), p = 0.033]. …”

Image 1_The effects of antioxidant supplementation on pain, oxidative stress markers, and clinical pregnancy rate in women with endometriosis: a systematic review and meta-analysis... by Yuchan Zhong (22518395)

“…The results showed that antioxidant supplementation significantly alleviated pelvic pain (continuous outcomes: SMD = −2.68; p < 0.00001; binary outcomes: RR = 9.31; p < 0.0001), dysmenorrhea (SMD = −1.77; p = 0.01; RR = 2.39; p = 0.03), and dyspareunia (SMD = −2.33; p = 0.01; RR = 5.40; p = 0.003), and significantly decreased peripheral blood malondialdehyde (MDA) levels (SMD = −7.58; p = 0.001). …”

Supplementary file 1_Clinical characteristics and mortality risk factors among hospitalized infants and children with pertussis in China: a retrospective study.docx by Shuhan Zheng (18614305)

“…The severe cases group exhibited significantly higher levels than the mild cases group in length of stay, duration of antibiotic treatment, white blood cell (WBC) count, pneumonia, respiratory failure, and tachypnea (p < 0.05). …”

Image 2_The effects of antioxidant supplementation on pain, oxidative stress markers, and clinical pregnancy rate in women with endometriosis: a systematic review and meta-analysis... by Yuchan Zhong (22518395)

“…The results showed that antioxidant supplementation significantly alleviated pelvic pain (continuous outcomes: SMD = −2.68; p < 0.00001; binary outcomes: RR = 9.31; p < 0.0001), dysmenorrhea (SMD = −1.77; p = 0.01; RR = 2.39; p = 0.03), and dyspareunia (SMD = −2.33; p = 0.01; RR = 5.40; p = 0.003), and significantly decreased peripheral blood malondialdehyde (MDA) levels (SMD = −7.58; p = 0.001). …”

Data Sheet 1_Effects of plant extracts on patients with heart failure: a network meta-analysis of randomized controlled trials.pdf by Jieyin Deng (22563188)

“…Astragalus extract demonstrated the highest efficacy in enhancing the 6-min walk test (6-MWT) score (surface under the cumulative ranking curve [SUCRA]: 90.70%) and reducing tumor necrosis factor-alpha (TNF-α) levels (SUCRA: 74.4%). Shenfu extract exhibited superior efficacy in decreasing B-type natriuretic peptide (BNP) values (SUCRA: 68.2%) and enhancing the quality of life (QL) (SUCRA: 77.0%). …”

Table 1_Effects and safety of Salvia miltiorrhiza on the improvement of renal function, inflammatory factors, and vascular endothelium in patients with diabetic kidney disease: a m... by Shuyu Zheng (5570231)

“…Notably, the safety profile remained sound, with no significant differences in adverse event rates between the two groups (P > 0.05).…”

Data Sheet 1_The relationship between inflammatory factors and heart failure: evidence based on bidirectional Mendelian randomization analysis.zip by Xuanchun Huang (17359851)

“…Reverse Mendelian randomization suggested that the onset of heart failure might potentially influence the levels of four inflammatory factors, with ARTN and FGF5 decreasing after the onset of heart failure, and SLAM and MMP-10 increasing. …”

Image 4_Interleukin-26 expression in tuberculosis disease and its regulatory effect in macrophage polarization and intracellular elimination of Mycobacterium tuberculosis.jpeg by Kaisong Huang (5412626)

“…Conversely, circulating IL-26 levels in the plasma of adult TB patients were markedly lower than those of healthy cohorts. …”

Image_4_Effect of probiotic supplementation combined with bismuth-containing quadruple therapy on gut microbiota during Helicobacter pylori eradication: a randomized, double-blind,... by Zhongxue Han (19855215)

“…After treatment, the GSRS score decreased significantly in the probiotic group (p = 0.039). …”

Table 1_The effect of omega-3 supplementation on metabolic, inflammatory and oxidative stress biomarkers in pregnant women: a systematic review and meta-analysis.docx by Mohamed J. Saadh (17931488)

“…However, triglyceride (SMD = −0.96, 95% CI: −1.77, −0.16) and CRP (SMD = −0.98, 95% CI: −1.86, −0.11) significantly decreased, and HDL-C cholesterol levels significantly increased (SMD = 0.72, 95% CI: 0.21, 1.22) following omega-3 supplementation.…”

Data Sheet 1_Interleukin-26 expression in tuberculosis disease and its regulatory effect in macrophage polarization and intracellular elimination of Mycobacterium tuberculosis.xlsx by Kaisong Huang (5412626)

“…Conversely, circulating IL-26 levels in the plasma of adult TB patients were markedly lower than those of healthy cohorts. …”

Data Sheet 3_Effects and safety of Salvia miltiorrhiza on the improvement of renal function, inflammatory factors, and vascular endothelium in patients with diabetic kidney disease... by Shuyu Zheng (5570231)

“…Notably, the safety profile remained sound, with no significant differences in adverse event rates between the two groups (P > 0.05).…”

In sepsis-associated cardiotoxicity, remifentanil reduces oxidative stress, inflammation, and apoptosis to maintain mitochondrial biogenesis by inhibiting NFkB and Cas-3 immunoexpr... by Muhammet Yusuf TEPEBAŞI (22576416)

“…It markedly decreased Cas-3, NF-κB, and TNF-α expression, lowered TOS and OSI levels, and modulated the BAX/BCL-2. …”

Table 1_Microplastics in focus: a silent disruptor of liver health- a systematic review.docx by Zahra Beyzaei (9911886)

“…., increased serum cysteine, decreased hepatic cysteine, and disturbed homocysteine metabolism), impair mitochondrial bioenergetics, and lead to significant lipid accumulation after exposures lasting up to 500 h. …”