Data Sheet 1_Genomic profiling of NSCLC tumors with the TruSight oncology 500 assay provides broad coverage of clinically actionable genomic alterations and detection of known and... by Zachary D. Wallen (19986522)

“…Known associations between genomic alterations and immunotherapy markers were observed including significantly lower TMB levels in tumors with therapy-associated alterations and significantly higher PD-L1 levels in tumors with ALK, MET, BRAF, or ROS1 driver mutations. …”

Table 4_Genomic profiling of NSCLC tumors with the TruSight oncology 500 assay provides broad coverage of clinically actionable genomic alterations and detection of known and novel... by Zachary D. Wallen (19986522)

“…Known associations between genomic alterations and immunotherapy markers were observed including significantly lower TMB levels in tumors with therapy-associated alterations and significantly higher PD-L1 levels in tumors with ALK, MET, BRAF, or ROS1 driver mutations. …”

Table 1_Genomic profiling of NSCLC tumors with the TruSight oncology 500 assay provides broad coverage of clinically actionable genomic alterations and detection of known and novel... by Zachary D. Wallen (19986522)

“…Known associations between genomic alterations and immunotherapy markers were observed including significantly lower TMB levels in tumors with therapy-associated alterations and significantly higher PD-L1 levels in tumors with ALK, MET, BRAF, or ROS1 driver mutations. …”

Table 5_Genomic profiling of NSCLC tumors with the TruSight oncology 500 assay provides broad coverage of clinically actionable genomic alterations and detection of known and novel... by Zachary D. Wallen (19986522)

“…Known associations between genomic alterations and immunotherapy markers were observed including significantly lower TMB levels in tumors with therapy-associated alterations and significantly higher PD-L1 levels in tumors with ALK, MET, BRAF, or ROS1 driver mutations. …”

Table 2_Genomic profiling of NSCLC tumors with the TruSight oncology 500 assay provides broad coverage of clinically actionable genomic alterations and detection of known and novel... by Zachary D. Wallen (19986522)

“…Known associations between genomic alterations and immunotherapy markers were observed including significantly lower TMB levels in tumors with therapy-associated alterations and significantly higher PD-L1 levels in tumors with ALK, MET, BRAF, or ROS1 driver mutations. …”

Conditional Knockout of Serine Racemase in Microglia Alleviates Alzheimer -like Pathology and Behavior by Reducing Neuroinflammation through Enhancing Histone Lactylation by shengzhou Wu (22341388)

“…Further, addition of C646, a p300 inhibitor or oxamate, an inhibitor of lactate dehydrogenase A, significantly reversed arginase1 or interleukin-10 mRNA levels in srr-/- microglia. …”

Table 3_Genomic profiling of NSCLC tumors with the TruSight oncology 500 assay provides broad coverage of clinically actionable genomic alterations and detection of known and novel... by Zachary D. Wallen (19986522)

“…Known associations between genomic alterations and immunotherapy markers were observed including significantly lower TMB levels in tumors with therapy-associated alterations and significantly higher PD-L1 levels in tumors with ALK, MET, BRAF, or ROS1 driver mutations. …”

Data Sheet 5_Overexpression of NK4 gene in TU212 affects migratory activity in laryngeal squamous cell carcinoma.xls by Yixuan Huo (21783825)

“…Transcriptome sequencing revealed that the expression levels of 320 genes differed significantly, with 189 upregulated and 131 downregulated genes.…”

Data Sheet 1_Integrated transcriptomic analysis identifies lactylation-linked gemcitabine resistance and therapeutic targets in intrahepatic cholangiocarcinoma.docx by Wenwei Xie (1987225)

“…The high group associated with resistance showed significantly worse survival outcomes, with a positive correlation between resistance and lactylation levels. …”

Data Sheet 3_Overexpression of NK4 gene in TU212 affects migratory activity in laryngeal squamous cell carcinoma.xls by Yixuan Huo (21783825)

“…Transcriptome sequencing revealed that the expression levels of 320 genes differed significantly, with 189 upregulated and 131 downregulated genes.…”

Data Sheet 6_Overexpression of NK4 gene in TU212 affects migratory activity in laryngeal squamous cell carcinoma.xls by Yixuan Huo (21783825)

“…Transcriptome sequencing revealed that the expression levels of 320 genes differed significantly, with 189 upregulated and 131 downregulated genes.…”

Data Sheet 1_Overexpression of NK4 gene in TU212 affects migratory activity in laryngeal squamous cell carcinoma.xls by Yixuan Huo (21783825)

“…Transcriptome sequencing revealed that the expression levels of 320 genes differed significantly, with 189 upregulated and 131 downregulated genes.…”

Data Sheet 2_Overexpression of NK4 gene in TU212 affects migratory activity in laryngeal squamous cell carcinoma.xls by Yixuan Huo (21783825)

“…Transcriptome sequencing revealed that the expression levels of 320 genes differed significantly, with 189 upregulated and 131 downregulated genes.…”

Data Sheet 4_Overexpression of NK4 gene in TU212 affects migratory activity in laryngeal squamous cell carcinoma.xls by Yixuan Huo (21783825)

“…Transcriptome sequencing revealed that the expression levels of 320 genes differed significantly, with 189 upregulated and 131 downregulated genes.…”

Protective effect of phosphoenolpyruvate carboxykinase 1 on inflammation and fibrotic progression of IgA nephropathy by Ya-yin Tan (21448519)

“…In experiments with SV40-transformed mouse glomerular mesangial cells (MCs), PCK1 and PPARγ protein expression levels were significantly decreased in polymeric IgA1 (pIgA1)-stimulated MCs, which contrasts with the increased expression of inflammatory and fibrotic factors. …”

Data Sheet 1_STING regulates NETs formation by activating GSDMD in influenza viral pneumonia.pdf by Rongrong Huang (819212)

“…Symptoms of pneumonia in STING-KO mice infected with PR8 were significantly milder than those in WT mice, and NETs were less likely to form in the lung tissue of STING-KO mice. …”

Image_3_Notoginsenoside R1 Protects Against Diabetic Cardiomyopathy Through Activating Estrogen Receptor α and Its Downstream Signaling.JPEG by Bin Zhang (64682)

“…In vitro experiments revealed that pretreatment with NGR1 significantly decreased AGEs-induced mitochondria injury, limited an increase in ROS, and reduced apoptosis in H9c2 cells. …”

Data Sheet 1_Lactobacillus paragasseri HM018 derived from breast milk ameliorates hyperlipidemia in high-cholesterol rats by modulating bile acid metabolism.docx by Chunyu Yao (13559263)

“…</p>Results and discussion<p>We established three dosage groups (2.5 × 10⁸, 5 × 10⁸, and 1.5 × 10⁹ CFU/rat), demonstrating that HM018 significantly reduced high-fat diet-induced serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, while ameliorating gut microbiota dysbiosis and decreasing the Firmicutes/Bacteroidetes ratio. …”

Supporting information Abou-Kandil et al. by Olaf Kniemeyer (8561361)

“…Both antifungals induced significantly increased levels of proteins involved in aromatic acid metabolism, transmembrane transport and secondary metabolite biosynthesis. …”

Data Sheet 1_Diversity, functionality, and stability: shaping ecosystem multifunctionality in the successional sequences of alpine meadows and alpine steppes on the Qinghai-Tibet P... by Xin Jin (108988)

“…These environmental shifts led to decreased species diversity, driven by lower precipitation and reduced soil nitrate-nitrogen levels, as well as community differentiation influenced by declining soil pH and precipitation. …”