Data Sheet 1_The relationship between intrinsic capacity and sarcopenia in middle-aged and older Chinese populations: the mediating influence of a novel nutritional index.zip حسب Hong Ding (135247)

"…Higher TCBI was associated with a 28% decrease in sarcopenia risk per unit increase (OR = 0.72, 95% CI: 0.58–0.90, p = 0.004). …"

Signal denoising in modular spiking networks حسب Barna Zajzon (8083532)

"…</p><p dir="ltr">Taken together, these results highlight the functional benefits of structured connectivity in hierarchical neural networks, and shed light on a potential new role for modular topographic maps as a denoising mechanism.…"

Data_Sheet_1_Deregulation of mTORC1-TFEB axis in human iPSC model of GBA1-associated Parkinson’s disease.docx حسب Fahad Mubariz (16010003)

"…Using PD patients’ induced-pluripotent stem cells (iPSCs), we examined TFEB activity and regulation of the ALP in dopaminergic neuronal cultures generated from iPSC lines harboring heterozygous GBA1 mutations and the CRISPR/Cas9-corrected isogenic controls. Our data showed a significant decrease in TFEB transcriptional activity and attenuated expression of many genes in the CLEAR network in GBA1 mutant neurons, but not in the isogenic gene-corrected cells. …"

Data Sheet 1_Luteolin induces apoptosis in Philadelphia chromosome-positive acute lymphoblastic leukemia cell by regulating the PI3K/AKT signaling pathway.zip حسب Qin Ren (150436)

"…They are prone to relapse, necessitating the urgent identification of new safe and effective treatment options. Luteolin (LUT), a natural flavonoid compound, has demonstrated significant anticancer activity. …"

Table3_The incidence, mortality and disease burden of cardiovascular diseases in China: a comparative study with the United States and Japan based on the GBD 2019 time trend analys... حسب Menglan Zhu (10268801)

"…</p>Results<p>In 2019, there were approximately 12,341,074 new diagnosed cases of CVDs in China, with 4,584,273 CVDs related deaths, causing 91,933,122 DALYs. …"

Data_Sheet_1_Effects of a 30-min rest with a nap chair on task performance, sleepiness, and neurophysiological measures in men with suspected brain fatigue: a randomized controlled... حسب Minoru Fujino (12742196)

"…The Karolinska Sleepiness score significantly decreased after the nap-chair rest, and the between-treatment difference in the decrease was highly significant (P = 0.0004). …"

Table 2_Oxphos targeting of MYCN-amplified neuroblastoma.xlsx حسب Soraya Epp (22489120)

"…Furthermore, low nanomolar concentrations of MitoQ significantly decrease MYCN protein expression and induce differentiation of MNA cells. …"

Table 1_Oxphos targeting of MYCN-amplified neuroblastoma.xlsx حسب Soraya Epp (22489120)

"…Furthermore, low nanomolar concentrations of MitoQ significantly decrease MYCN protein expression and induce differentiation of MNA cells. …"

Data Sheet 1_Oxphos targeting of MYCN-amplified neuroblastoma.pdf حسب Soraya Epp (22489120)

"…Furthermore, low nanomolar concentrations of MitoQ significantly decrease MYCN protein expression and induce differentiation of MNA cells. …"

Table_1_Outcomes of retroperitoneal fibrosis-related hydronephrosis and its risk factors for poor prognosis: a multi-center retrospective cohort study in Chinese patients.DOCX حسب figshare admin frontiersin (4545187)

"…Glucocorticoid-based therapy could reduce the time of stenting, decrease the need for long-term ureteral stenting/percutaneous nephrostomy (PNS)/ureterolysis, increase the rate of mass shrinkage, and reduce the new requirement of hemodialysis compared to surgery-only strategy for RPF-related hydronephrosis patients in need of renal drainage, but did not reduce new-onset renal atrophy.…"

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity حسب Julian Loureiro (20357035)

"…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…"

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity حسب Julian Loureiro (20357035)

"…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…"

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity حسب Julian Loureiro (20357035)

"…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…"

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity حسب Julian Loureiro (20357035)

"…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…"

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity حسب Julian Loureiro (20357035)

"…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…"

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity حسب Julian Loureiro (20357035)

"…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…"

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity حسب Julian Loureiro (20357035)

"…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…"

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity حسب Julian Loureiro (20357035)

"…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…"

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity حسب Julian Loureiro (20357035)

"…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…"

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity حسب Julian Loureiro (20357035)

"…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…"