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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
significant new » significant non (Expand Search), significant genes (Expand Search), significant anti (Expand Search)
new decrease » nn decrease (Expand Search), we decrease (Expand Search), mean decrease (Expand Search)
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1521
Table 2_Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequenc...
Published 2025“…Histological analysis revealed that Chaga treatment significantly reduced renal tubular damage scores [from 5.00 (5.00, 5.00) to 2.00 (2.00, 2.00), p < 0.05] and decreased collagen deposition area (from 11.40% ± 3.01% to 4.06% ± 0.45%, p < 0.05) at day 14. …”
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1522
Image 3_Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequenc...
Published 2025“…Histological analysis revealed that Chaga treatment significantly reduced renal tubular damage scores [from 5.00 (5.00, 5.00) to 2.00 (2.00, 2.00), p < 0.05] and decreased collagen deposition area (from 11.40% ± 3.01% to 4.06% ± 0.45%, p < 0.05) at day 14. …”
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1523
Image 2_Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequenc...
Published 2025“…Histological analysis revealed that Chaga treatment significantly reduced renal tubular damage scores [from 5.00 (5.00, 5.00) to 2.00 (2.00, 2.00), p < 0.05] and decreased collagen deposition area (from 11.40% ± 3.01% to 4.06% ± 0.45%, p < 0.05) at day 14. …”
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1524
Table 1_Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequenc...
Published 2025“…Histological analysis revealed that Chaga treatment significantly reduced renal tubular damage scores [from 5.00 (5.00, 5.00) to 2.00 (2.00, 2.00), p < 0.05] and decreased collagen deposition area (from 11.40% ± 3.01% to 4.06% ± 0.45%, p < 0.05) at day 14. …”
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1525
Image 1_iPSC-derived exosomes as amphotericin B carriers: a promising approach to combat cryptococcal meningitis.tif
Published 2025“…Background<p>Cryptococcal meningitis (CM) is a significant global health issue, particularly affecting individuals with HIV. …”
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1526
Data Sheet 1_CD19+ B cell depletion: a novel strategy to alleviate ischemic stroke damage.pdf
Published 2025“…Current treatments primarily involve thrombolytic therapy, limited to a 4.5-hour window due to the risk of complications, underscoring the need for new therapeutic targets. Systemic inflammation plays a critical role in stroke progression, with immune cells infiltrating the brain and exacerbating damage. …”
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1527
Impact of COVID-19 on early intervention referrals (Zellner et al., 2025)
Published 2025“…</p><p dir="ltr"><b>Method: </b>We obtained monthly service provision data, including new referrals and enrollments, from 2015 through 2021 from 44 Part C coordinating agencies. …”
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1528
Data Sheet 1_EURAD state-of-the-art report: thermo-hydro-mechanical behaviour of clay buffers at high temperatures.pdf
Published 2025“…The clay mineralogy was significantly preserved. The slight changes observed in the other properties were opposite depending on the heating conditions: in the case of evaporation, the cation exchange capacity, specific surface area, sorption coefficients, and sometimes swelling pressure decreased. …”
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1529
Data Sheet 1_The MTNR1B Rs724030 variant is associated with islet function and women waist-to-hip ratio in healthy subjects.pdf
Published 2025“…All these findings provide a basis for accurately assessing islet function in healthy populations and offer a new perspective on precision prevention.</p>…”
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1530
Data Sheet 1_Targeting the leptin receptor promotes MDA-MB-231 cells’ metabolic reprogramming and malignancy: the role of extracellular vesicles derived from obese adipose tissue.d...
Published 2025“…This study underscores the importance of EVs in the obesity-cancer link and offers new insights for therapeutic strategies targeting leptin signaling and EV-mediated communication in breast cancer.…”
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1531
Pathogenicity and transmissibility differences in goose-originated subgenotype 3 duck Tembusu virus in goose embryos and 3-day-old goslings
Published 2024“…In the autumn of 2022, an outbreak of an infectious disease resembling DTMUV was reported in Guangdong Province, China, which caused significantly high mortality in goose embryos, and decreased egg production. …”
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1532
Data Sheet 1_The CD38+HLA-DR+ T cells with activation and exhaustion characteristics as predictors of severity and mortality in COVID-19 patients.docx
Published 2025“…These cells’ unique activated-exhausted phenotype, along with their impact on NAD<sup>+</sup> metabolism, provides new insights into COVID-19 immunopathogenesis.</p>…”
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1533
Supplementary file 1_Integrating Drosophila and Vibrio fischeri models for toxicity evaluation: uncovering detoxification trends in psoralea Fructus-TCM formulations.docx
Published 2025“…Enzyme assays indicated a decreasing toxicity trend for ESP and SSP compared to PF, with significant changes observed in female flies. …”
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1534
Data Sheet 1_Antiviral therapy can effectively suppress irAEs in HBV positive hepatocellular carcinoma treated with ICIs: validation based on multi machine learning.zip
Published 2025“…However, Immunotherapy-related adverse reactions are still a major challenge faced by tumor immunotherapy, so it is urgent to establish new methods to effectively predict immunotherapy-related adverse reactions.…”
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1535
Table 1_An evaluation of the impact of abattoir processing on the levels of Campylobacter spp. and Enterobacteriaceae on broiler carcasses.docx
Published 2025“…The abattoir was found unsatisfactory regarding compliance with PHC for Campylobacter levels within the sampling window, but satisfactory when the new proposed PHC for Enterobacteriaceae levels was applied. …”
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1536
SEAwise Report on the impacts of fisheries on stocks and landings under SEAwise EBFM
Published 2025“…The ecosystem model generally showed less optimistic outcomes under climate change, with significant decreases in biomass and catches in both the Celtic and North Seas. …”
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1537
The relationship between early-onset preeclampsia and the prognostic nutritional index and inflammatory markers
Published 2024“…In our study, we investigated whether the prognostic nutritional index (PNI) and pan immune inflammation value (PIV), which are used in the prognosis and prediction of diseases in new studies in the literature, are useful for predicting early-onset preeclampsia.…”
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1538
Video 2_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4
Published 2025“…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. Despite significant progress in systemic and immune-based therapies, many patients develop resistance or fail to respond, highlighting the need for new molecular targets. …”
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1539
Video 5_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4
Published 2025“…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. Despite significant progress in systemic and immune-based therapies, many patients develop resistance or fail to respond, highlighting the need for new molecular targets. …”
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1540
Data Sheet 1_Global burden of cancer in adolescents and young adults aged 10–24 years: a trend analysis.pdf
Published 2025“…The age-standardized death rate(ASDR) and age-standardized DALY rate of total cancer have decreased significantly globally in adolescents and young adults aged 10–24 years. …”