Table 1_Effects of low-frequency and high-frequency electroacupuncture pretreatment on the COX-2/mPGES-1/PGE2 pathway in a rat model of cold-coagulation dysmenorrhea.xlsx by Yue Song (162328)

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) and hormonal contraceptives are the first-line treatments for dysmenorrhea; however, they have significant side effects. Electroacupuncture, as a non-invasive and effective therapeutic method, is widely used as a complementary and alternative treatment, although its mechanism of action remains unclear.…”

Image 1_Safety assessment of temozolomidee: real-world adverse event analysis from the FAERS database.png by Yu Liu (6938)

“…Methods for identifying temozolomide-related AEs signals include taking a case/non-case approach. Specific detection algorithms also include report Odds ratio (ROR), Proportional Report ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and multi-item Gamma-Poisson constrictor (MGPS).…”

Table 1_Trends in diet structural composition and quality among adults in Beijing, China (2010–2022).docx by Ningsu Chen (18014155)

“…Background<p>Unbalanced dietary patterns are a major risk factor for chronic non-communicable diseases. Examining trends in population-level dietary structural composition and quality is essential for monitoring nutritional transitions, identifying key dietary risks, and developing targeted public health policies.…”

Image3_A novel functional IKBKE variant activating NFAT in a patient with polyarthritis and a remittent fever.jpeg by Saeko Yamada (11899439)

“…Background<p>IKBKE is a negative regulator of T cell activation and one of the key activators of type I interferon (IFN) and NFκB signaling via non-classical pathways. The upstream single nucleotide polymorphism of IKBKE (rs2297550-G) is a genome-wide association study risk variant of systemic lupus erythematosus, and is associated with decreased IKBKE expression in T cells by expression quantitative trait locus analysis.…”

DataSheet1_A novel functional IKBKE variant activating NFAT in a patient with polyarthritis and a remittent fever.docx by Saeko Yamada (11899439)

“…Background<p>IKBKE is a negative regulator of T cell activation and one of the key activators of type I interferon (IFN) and NFκB signaling via non-classical pathways. The upstream single nucleotide polymorphism of IKBKE (rs2297550-G) is a genome-wide association study risk variant of systemic lupus erythematosus, and is associated with decreased IKBKE expression in T cells by expression quantitative trait locus analysis.…”

Table 1_Forest bathing enhances sleep, mood, and immunity: insights from low-latitude evergreen broad-leaved forests.xlsx by Xiangheng Dai (21684431)

“…Serum AQP9 and HSPA6 levels decreased, while salivary IgA and lysozyme surged.</p>Discussion<p>These findings suggest forest bathing offers immediate and multidimensional health benefits, highlighting its potential as a non-pharmacological intervention for holistic well-being. …”

Supplementary Material for: Construction of a hybrid vaccine based on Der f 35-derived peptides with reduced allergenicity by Hu H. (4145581)

“…The levels of IL-5 and IL-13 from PBMCs were significantly decreased after stimulation by the vaccine than that by Der f 35 (p < 0.05). …”

Image 1_Effect of hypoxia-induced mIL15 expression on expansion and memory progenitor stem-like TILs in vitro.tif by Zhen Sun (269397)

“…RNA-Seq data revealed that in TIL-mIL15-IL2 cells, the expression of genes related to T cell differentiation and effector function, including PRDM1, ID2, EOMES, IFNG, GZMB, and TNF, were significantly decreased, whereas the expression of the memory stem-like T cell marker TCF7 was significantly increased. …”

Image1_A novel functional IKBKE variant activating NFAT in a patient with polyarthritis and a remittent fever.jpeg by Saeko Yamada (11899439)

“…Background<p>IKBKE is a negative regulator of T cell activation and one of the key activators of type I interferon (IFN) and NFκB signaling via non-classical pathways. The upstream single nucleotide polymorphism of IKBKE (rs2297550-G) is a genome-wide association study risk variant of systemic lupus erythematosus, and is associated with decreased IKBKE expression in T cells by expression quantitative trait locus analysis.…”

Image2_A novel functional IKBKE variant activating NFAT in a patient with polyarthritis and a remittent fever.jpeg by Saeko Yamada (11899439)

“…Background<p>IKBKE is a negative regulator of T cell activation and one of the key activators of type I interferon (IFN) and NFκB signaling via non-classical pathways. The upstream single nucleotide polymorphism of IKBKE (rs2297550-G) is a genome-wide association study risk variant of systemic lupus erythematosus, and is associated with decreased IKBKE expression in T cells by expression quantitative trait locus analysis.…”

DataSheet_1_Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profile.docx by Rocío Rubio (513839)

“…<p>SARS-CoV-2 infected pregnant women are at increased risk of severe COVID-19 than non-pregnant women and have a higher risk of adverse pregnancy outcomes like intrauterine/fetal distress and preterm birth. …”

Data_Sheet_1_A randomized double-blinded study assessing the effect of different doses of transnasal dexmedetomidine on the median effective concentration of ropivacaine for a caud... by Fu Wang (10556)

“…Compared to group IN-NS, the EC50 value of ropivacaine in IN-DEX2 was significantly decreased by 21.4% (p = 0.001), while there was no significant difference between group IN-NS and IN-DEX1 (p = 0.125). …”

Loss of H2A.Z from transcription start sites was correlated with, but not required for, HU-induced gene activation. by Hilary T. Brewis (11798006)

“…The p-values, generated using hypergeometric probability, indicate if the overlap in each group was significantly greater (red) or less (blue) than excepted by chance (black = non-significant). …”

Data Sheet 1_Chinese patent medicine tongxinluo capsule as a supplement to treat chronic coronary syndromes: a GRADE-assessed systematic review and meta-analysis of randomized cont... by Shi-Bing Liang (10200806)

“…Adding TXL to WM showed a non-significant trend toward reducing myocardial infarction [RR 0.34, 95% CI (0.05, 2.12); NNT = 41] and sudden cardiac death [RR 0.34, 95% CI (0.01, 8.28); NNT = 65]. …”

Supplementary Material for: Angiopausin® and Angiopoietin: Unveiling New Mechanisms in Rosacea Treatment through Kinetic Erythema Analysis with the AAREA® Algorithm by figshare admin karger (2628495)

“…Introduction: Non-transient erythema (NTE) is a major feature of rosacea, but its clinical evaluation is subject to human investigator variability. …”

Table 1_Probabilistic human health risk assessment of commercially supplied jar water in Gopalganj municipal area, Bangladesh.docx by Partha Pratim Brahma (19696279)

“…<p>Every day, the amount of quality fresh water decreases notably due to contamination of drinking water. …”

Image 2_A unique polygenic mouse model of obesity exhibits a distinct immunological profile that may offer protection against systemic inflammation, diabetes, and behavioral impair... by Ulrike Gimsa (9730208)

“…Unlike other mouse lines, DU6 mice do not develop diabetes despite significant obesity. We performed a series of behavioral tests on male mice because obesity is often associated with cognitive and emotional impairment. …”

Table 2_Strategies to support the mental health and well-being of health and care workforce: a rapid review of reviews.docx by Cindy E. Frias (20899853)

“…Health and care workforce report significantly greater levels of job-related burnout and mental health problems, which in turn are associated with poorer patient outcomes, increased medical errors, diminished quality and safety, decreased patient satisfaction, and reduced healthcare efficiency.…”

Data Sheet 1_From court to community: a cost–benefit evaluation of a community sports programme for Arab women in Israel's multiethnic context.docx by Limor Dina Gonen (14258380)

“…Gains in mental well-being were observed but did not reach statistical significance (p = 0.09). Modest increases were found in social capital and community engagement. …”

Table 1_Strategies to support the mental health and well-being of health and care workforce: a rapid review of reviews.docx by Cindy E. Frias (20899853)

“…Health and care workforce report significantly greater levels of job-related burnout and mental health problems, which in turn are associated with poorer patient outcomes, increased medical errors, diminished quality and safety, decreased patient satisfaction, and reduced healthcare efficiency.…”