Design, synthesis and biological evaluation of non-glucosidal based 1,3,4-thiadiazoles as SGLT-2 inhibitors by Shivani Sharma (255210)

“…SSS 6 and SSS 2 significantly decreased blood glucose levels (137 ± 4.89 mg/dL and 183 ± 15.07 mg/dL) relative to dapagliflozin (158 ± 15.9 mg/dL).…”

Data Sheet 1_Anti-neoplastic effects of the antipsychotic drug penfluridol in preclinical prostate cancer models.pdf by Arjanneke F. van de Merbel (5809940)

“…</p>Results<p>Penfluridol significantly reduced the viability of a panel of human PCa cells, induced apoptosis by increasing caspase-3/7 levels and decreased the number of PCa stem cells in vitro. …”

Data Sheet 2_Anti-neoplastic effects of the antipsychotic drug penfluridol in preclinical prostate cancer models.docx by Arjanneke F. van de Merbel (5809940)

“…</p>Results<p>Penfluridol significantly reduced the viability of a panel of human PCa cells, induced apoptosis by increasing caspase-3/7 levels and decreased the number of PCa stem cells in vitro. …”

DataSheet1_Changes in serum uteroglobin level in type 2 diabetes mellitus patients.docx by Joung Youl Lim (18237598)

“…Uteroglobin is a potential early biomarker that reflects a chronic inflammatory condition in T2D.…”

Table 1_Complex evaluation of coagulation, fibrinolysis, and inflammatory cytokines in SARS-CoV-2 infected pregnant women: a prospective, case-control study.docx by Zsuzsa Bagoly (429210)

“…Admission IL-1β, and IL-33 were significantly lower, while IL-18 was significantly higher in cases when COVID-19 became more severe, along with significantly decreased FVIII, FXIII and plasminogen. …”

Data Sheet 1_Cognitive component of auditory attention to natural speech events.pdf by Nhan Duc Thanh Nguyen (20506628)

“…Importantly, the component decreases in strength but is still significantly observable in increasingly realistic paradigms of multi-talker environments. …”

Vasculogenic mimicry in melanoma tissue : immunohistochemistry, cell growth & morphological assays, migration & invasion assays and protein expression analyses by Rakolote Matlala (11071533)

“…This dataset provides mechanistic insights and supports the therapeutic potential of targeting VEGFR-1 in melanoma.</p>…”

Data Sheet 1_Impact of drought stress on biochemical and molecular responses in lavender (Lavandula angustifolia Mill.): effects on essential oil composition and antibacterial acti... by Ramin Hosseini (21023861)

“…<p>Drought stress significantly influences the physiological, biochemical, and molecular processes in plants, directly impacting their growth and defense mechanisms. …”

Mitigation of Senescence Burden in Doxorubicin-Induced Senescent Endothelial Cells by MitoQ Treatment Through Diminishing Mitochondrial ROS and DNA Damage. by Hossein Abdeahad (22177792)

“…DOXO increased mtROS, decreased mitochondrial mass, and induced senescence. …”

Identification of Alzheimer’s disease susceptibility genes by the integration of genomics and transcriptomics by Chenghong OuYang (13521682)

“…Through Mendelian randomization (MR) analysis, it was found that the risk of AD was significantly increased when VASP expression increased (OR = 0.1.046), while the risk of AD was significantly decreased when SURF2 (OR = 0.897) and TARBP1(OR = 0.920) expression increased. …”

Table1_CHF6297: a novel potent and selective p38 MAPK inhibitor with robust anti-inflammatory activity and suitable for inhaled pulmonary administration as dry powder.DOCX by Cataldo Martucci (3117069)

“…In a murine house dust mite (HDM) model of asthma exacerbated by influenza virus A (IAV) (H3N3), CHF6297 (0.1 mg/kg, i.n.) significantly decreased airway neutrophilia compared to vehicle-treated IAV/HDM-challenged mice. …”

Image1_Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis.tif by Zi Yang (276531)

“…The gene expression levels of cytokines and chemokines, including Ccl12, Ccl3, Il1r1, Ccr2, Cx3cr1, Il7, Mmp2, Mmp14, Il1b, and Il7, significantly decreased after treatment with MYDGF, as determined by RNA sequencing. …”

Table1_Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis.docx by Zi Yang (276531)

“…The gene expression levels of cytokines and chemokines, including Ccl12, Ccl3, Il1r1, Ccr2, Cx3cr1, Il7, Mmp2, Mmp14, Il1b, and Il7, significantly decreased after treatment with MYDGF, as determined by RNA sequencing. …”

Image1_Comprehensive analysis of Hibisci mutabilis Folium extract’s mechanisms in alleviating UV-induced skin photoaging through enhanced network pharmacology and experimental vali... by Wenyuan Chen (1770583)

“…However, the therapeutic potential of HMF in preventing and treating UV-induced skin photoaging remains unexplored.…”

Image3_Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis.tif by Zi Yang (276531)

“…The gene expression levels of cytokines and chemokines, including Ccl12, Ccl3, Il1r1, Ccr2, Cx3cr1, Il7, Mmp2, Mmp14, Il1b, and Il7, significantly decreased after treatment with MYDGF, as determined by RNA sequencing. …”

Image4_Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis.tif by Zi Yang (276531)

“…The gene expression levels of cytokines and chemokines, including Ccl12, Ccl3, Il1r1, Ccr2, Cx3cr1, Il7, Mmp2, Mmp14, Il1b, and Il7, significantly decreased after treatment with MYDGF, as determined by RNA sequencing. …”

Image2_Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis.tif by Zi Yang (276531)

“…The gene expression levels of cytokines and chemokines, including Ccl12, Ccl3, Il1r1, Ccr2, Cx3cr1, Il7, Mmp2, Mmp14, Il1b, and Il7, significantly decreased after treatment with MYDGF, as determined by RNA sequencing. …”

Image2_Comprehensive analysis of Hibisci mutabilis Folium extract’s mechanisms in alleviating UV-induced skin photoaging through enhanced network pharmacology and experimental vali... by Wenyuan Chen (1770583)

“…However, the therapeutic potential of HMF in preventing and treating UV-induced skin photoaging remains unexplored.…”

DataSheet1_Comprehensive analysis of Hibisci mutabilis Folium extract’s mechanisms in alleviating UV-induced skin photoaging through enhanced network pharmacology and experimental... by Wenyuan Chen (1770583)

“…However, the therapeutic potential of HMF in preventing and treating UV-induced skin photoaging remains unexplored.…”

Table 1_Lannea edulis lowers blood glucose by modulating absorption, utilization, and pancreatic function in diabetic rats.docx by Gilbert Lutangu (21898643)

“…Treatment with 0.5 mg/mL of the leaf extract significantly decreased the movement of glucose from the mucosal side to the serosa in the everted rat jejunum (p < 0.001) and significantly increased glucose uptake by the hemidiaphragm at 1 mg/mL (p = 0.0029) and 2 mg/mL (p = 0.0479). …”