Docetaxel and quercetin-loaded lipid nanocarrier optimized by quality by design for glioblastoma therapy: a ligand-conjugated and therapeutic repurposing approach by Zufika Qamar (22259678)

“…Compared to non-conjugated NLC and (DTX-QUR) suspension (SUS), Tf-(DTX-QUR) NLC showed 3.6- and 5.8-fold decrease in IC₅₀, respectively. Cellular uptake studies demonstrated significantly (<i>***p < 0.001</i>) high internalization of Tf-conjugated NLC to U87-MG cells. …”

Data Sheet 1_Quantitative proteomic analysis reveals potential serum diagnostic markers for colorectal adenoma.docx by Chengli Yu (1445185)

“…Early detection and removal of precancerous lesions during the adenoma-carcinoma sequence can significantly reduce CRC risk. However, current clinical practice lacks rapid, noninvasive screening tools for reliable adenoma detection.…”

Table 5_Quantitative proteomic analysis reveals potential serum diagnostic markers for colorectal adenoma.xlsx by Chengli Yu (1445185)

“…Early detection and removal of precancerous lesions during the adenoma-carcinoma sequence can significantly reduce CRC risk. However, current clinical practice lacks rapid, noninvasive screening tools for reliable adenoma detection.…”

Data Sheet 1_Chemopreventive and therapeutic effects of Hippophae rhamnoides L. fruit peels evaluated in preclinical models of breast carcinoma.docx by Dana Dvorska (19809111)

“…In the 4T1 mouse model, seaberry treatment resulted in a significant, dose-dependent reduction in tumor volume (43% and 48% compared to controls) and a decrease in the mitotic activity index. …”

Supplementary file 1_Indirect regeneration of long-term callus cultures in gladiolus: a protocol for stable genetic fidelity.docx by Seyedehraziyeh Mousavimatin (21398525)

“…This medium led to an 80% decrease in the accumulation of phenolic compounds across all cultivars in comparison to the control. …”

Table 1_Enhancement of oxaliplatin efficacy and amelioration of intestinal epithelial damage by Lactobacillus rhamnosus GG through modulation of gut microbiota.xlsx by Zijie Zhang (2543533)

“…Specifically, the Oxp group exhibited a decrease in Clostridium_XlVa and an increase in Desulfovibrio, indicating a shift in microbial balance. …”

<b>Triptolide alleviates </b><b>cognitive</b><b> impairment via </b><b>autophagy</b><b> and Akt/mTOR/p70S6K pathway in an APP/PS1 Alzheimer’s disease mouse model</b> by xinyao Qi (21686459)

“…</p><p dir="ltr">The Morris Water Maze (MWM) test assessed cognitive function, where TP treatment significantly decreased escape latencies in AD mice without affecting swimming speeds, suggesting improved spatial learning and memory independent of motor function. …”

Cardiac-targeted and ROS-responsive liposomes containing puerarin for attenuating myocardial ischemia-reperfusion injury by Yan Wang (15435)

“…</p> <p><i>In vivo</i> and <i>ex vivo</i> results showed that PUE@TK/CHP-L can effectively reduce the level of myocardial oxidative stress and decrease cardiomyocyte apoptosis and ferroptosis.</p> <p>These results suggested that PUE@TK/CHP-L could hopefully be a promising drug carrier for mitigating MI/RI.…”

Data Sheet 1_Yeast cell wall derivatives as a potential strategy for modulating oral microbiota and dental plaque biofilm.docx by Torsten P. M. Scheithauer (10950975)

“…</p>Conclusion<p>This study has demonstrated the potential of yeast cell wall derivatives to positively impact oral health by significantly reducing biofilm density, modulating the oral microbial composition, and decreasing the production of short-chain fatty acids. …”

Data Sheet 1_Role of memantine in adult migraine: a systematic review and network meta-analysis to compare memantine with existing migraine preventive medications.docx by Guanglu Li (2315128)

“…</p>Conclusion<p>This study provides prioritisation evidence for memantine in migraine prevention, as memantine can significantly decrease the frequency of migraine attacks, improves response rates, and fair acceptability. …”

Data Sheet 4_Combined treatment with anti-PSMA antibody and human peripheral blood-derived NK cells for castration-resistant prostate cancer.docx by Fangming Wang (2810719)

“…CD16 is abundantly expressed in PB-NK cells. The anti-PSMA Ab significantly enhanced the cytotoxicity of NK cells against CRPC cells in vitro, evidenced by increased killing rate, upregulation of the degranulation marker CD107a, increased secretion of interferon-γ, and decreased PSA levels. …”

Data Sheet 3_Combined treatment with anti-PSMA antibody and human peripheral blood-derived NK cells for castration-resistant prostate cancer.docx by Fangming Wang (2810719)

“…CD16 is abundantly expressed in PB-NK cells. The anti-PSMA Ab significantly enhanced the cytotoxicity of NK cells against CRPC cells in vitro, evidenced by increased killing rate, upregulation of the degranulation marker CD107a, increased secretion of interferon-γ, and decreased PSA levels. …”

Data Sheet 2_Combined treatment with anti-PSMA antibody and human peripheral blood-derived NK cells for castration-resistant prostate cancer.docx by Fangming Wang (2810719)

“…CD16 is abundantly expressed in PB-NK cells. The anti-PSMA Ab significantly enhanced the cytotoxicity of NK cells against CRPC cells in vitro, evidenced by increased killing rate, upregulation of the degranulation marker CD107a, increased secretion of interferon-γ, and decreased PSA levels. …”

Data Sheet 1_Combined treatment with anti-PSMA antibody and human peripheral blood-derived NK cells for castration-resistant prostate cancer.xlsx by Fangming Wang (2810719)

“…CD16 is abundantly expressed in PB-NK cells. The anti-PSMA Ab significantly enhanced the cytotoxicity of NK cells against CRPC cells in vitro, evidenced by increased killing rate, upregulation of the degranulation marker CD107a, increased secretion of interferon-γ, and decreased PSA levels. …”

Data Sheet 2_A novel molecule targeting neutrophil-mediated B-1a cell trogocytosis attenuates sepsis-induced acute lung injury.pdf by Yuichi Akama (17892940)

“…Our data showed that B-1a cell numbers and frequencies in the pleural and peritoneal cavities were significantly decreased in sepsis. Neutrophils co-cultured with B-1a cells significantly increased B-1a cell internalization via trogocytosis. …”

Data Sheet 1_A novel molecule targeting neutrophil-mediated B-1a cell trogocytosis attenuates sepsis-induced acute lung injury.pdf by Yuichi Akama (17892940)

“…Our data showed that B-1a cell numbers and frequencies in the pleural and peritoneal cavities were significantly decreased in sepsis. Neutrophils co-cultured with B-1a cells significantly increased B-1a cell internalization via trogocytosis. …”

Image1_The fruit fly Drosophila melanogaster as a screening model for antiseizure medications.JPEG by Florian P. Fischer (14457072)

“…Despite numerous newly marketed ASMs, the proportion of drug-resistant people with epilepsy has not significantly decreased over the years. Therefore, novel and innovative seizure models for preclinical drug screening are highly desirable. …”

Data Sheet 1_Thymoquinone/β-N-acetylglucosaminidase, a novel plant-derived combination, inhibited quorum sensing signaling pathways and disrupted biofilm in Staphylococcus aureus.p... by Adel Attia M. Ahmad (16729177)

“…Identifying herbal compounds, especially those comprising enzymes, with antibacterial and biofilm-degrading properties offers a promising alternative to conventional biofilm inhibitors. …”

Table 1_Thymoquinone/β-N-acetylglucosaminidase, a novel plant-derived combination, inhibited quorum sensing signaling pathways and disrupted biofilm in Staphylococcus aureus.docx by Adel Attia M. Ahmad (16729177)

“…Identifying herbal compounds, especially those comprising enzymes, with antibacterial and biofilm-degrading properties offers a promising alternative to conventional biofilm inhibitors. …”

Table 1_HIF1A acts as target of XiHuang Pill in the treatment of papillary thyroid cancer by regulating dedifferentiation.xlsx by Xu-Zhe Yu (21509801)

“…Traditional Chinese Medicine, particularly Xihuang Pill (XHP), has demonstrated promising anticancer potential in various tumors, but its molecular mechanisms in PTC remain unclear. …”