Flt3L-derived Antigen Presenting Cell transfer in neonatal NOD mice delays the incidence of Type 1 by Stephanie Orozco (7379687)

“…Thus, we hypothesize that the transfer of tolerogenic APCs at the neonatal stage prior to priming and immune infiltration will result in effective protection from autoimmunity. Our studies demonstrate that immature APCs travel to the pancreatic draining lymph nodes, alter the cytokine milieu in young mice, divert autoreactive CD4⁺ T cells to anergy and drastically decrease proliferation and function of CTLs in adult pre-diabetic mice leading to a significant reduction in the incidence of T1D.…”

Table 1_Shenfu injection promotes self-renewal of intestinal stem cells in sepsis-induced intestinal injury via inducing ATF4 expression.docx by Yunxin Deng (11052077)

“…</p>Results<p>Plasma levels of D-lactate and intestinal-type fatty acid-binding protein (I-FABP) in septic patients with intestinal dysfunction were significantly reduced following SFI administration. Compared to the control mice, sepsis induced severe mucosal damage in the intestine, including the decrease of the villus length and the number of crypts, which was significantly inhibited by SFI administration. …”

Table 1_The adjunctive role of metformin in patients with mild to moderate ulcerative colitis: a randomized controlled study.docx by Ammena Y. Binsaleh (16631313)

“…</p>Study outcomes<p>Decrease in DAI and change in the level of measured serum and fecal markers.…”

Supplementary file 2_Wuzi-Yanzong-Wan inhibits testicular mitochondrial apoptosis in rats by downregulating TAp73-Mediated P38 MAPK-ADAM17 pathway.docx by Ziao Liu (8938748)

“…Mechanistic investigations revealed that WZYZW markedly suppressed germ cell apoptosis (flow cytometry confirmed a significant decrease in apoptotic cell proportion) and attenuated DNA damage (indicated by significantly reduced γ-H2AX (a DNA damage marker) fluorescence intensity). …”

Presentation 1_Seasonal and spatial variations of nutrients and environmental effects under anthropogenic influence in Daya Bay, China.pdf by Jincheng Zhao (3625676)

“…This study provides timely information regarding recent shifts in ecological indicators and is significant to the ecological protection, environmental management, and policy adjustment in Daya Bay.…”

Supplementary Material for: Role of melatonin in intestinal mucosal injury induced by chronic restraint stress in mice by figshare admin karger (2628495)

“…The present study investigated the mechanisms of MT-mediated protection against chronic restraint stress-induced GIMD. …”

<b>Microplastic and drought influence the positive effect of plant diversity on plant biomass production</b> by Jing Man (22181824)

“…Nevertheless, microplastic tended to decrease this positive relationship by reducing positive selection effect through suppressed shoot biomass of grasses and legumes. …”

Table_1_Does disaster resettlement reshape household livelihood adaptive capacity in rural China?.xlsx by Tiejun Zhao (230582)

“…The results show that: (1) disaster resettlement significantly reduces HLAC, and (2) poverty alleviation relocation, centralized resettlement, and short-distance relocation have a significant negative impact on HLAC. …”

Data Sheet 1_Non-stationary response of Pacific saury (Cololabis saira) in the northwestern Pacific to climate variability.docx by Chang Cao (2592700)

“…The dynamics of Pacific saury from 1970 to 2021 could be divided into four periods: the 1970s and 1980s when the Siberian High and the intensification of the East Asian winter monsoon drove down the water temperature, providing a suitable habitat and resulting in an increase in resource abundance; In the 1990s, the rise in temperature led to a reduction in resource abundance; At the beginning of the 21st century, the enhancement of the Siberian High brought about a suitable habitat, and the resource abundance showed a significant increase; The unfavorable high water temperature environment in the 2010s caused the resource abundance to decrease once again. …”

Data Sheet 1_Photodynamic therapy with a novel photosensitizer inhibits DSS-induced ulcerative colitis in rats via the NF-κB signaling pathway.docx by Yumei Rong (11589031)

“…Mechanism studies demonstrated that LD₄-PDT could inhibit the NF-κB signaling pathway, downregulated the expression of the inflammatory factors’ tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and myeloperoxidase (MPO), increased the contents of glutathione (GSH) and superoxide dismutase (SOD) and decreased the content of malondialdehyde (MDA). Additionally, analysis of gut microbiota revealed that LD₄-PDT treatment could decrease the abundance of the Proteobacteria phylum in fecal samples, while no significant differences were observed in the Firmicutes, Bacteroidetes, or Actinobacteria phyla among the three groups using 16S rRNA analysis.…”

Data Sheet 1_Effects of cattle manure and sludge vermicompost on nutrient dynamics and yield in strawberry cultivation with distinct continuous cropping histories in a greenhouse.d... by Xiaofeng Bai (711688)

“…<p>Continuous cropping has emerged as a significant challenge affecting yield and quality in greenhouse strawberries, particularly as the cultivation of strawberries as a protected crop continues to increase. …”

Data Sheet 1_Association of the dietary index for gut microbiota with sleep disorder among US adults: the mediation effect of dietary inflammation index.docx by Yingying Li (50341)

“…</p>Results<p>The DI-GM score was significantly negatively correlated with sleep disorders. …”

Data Sheet 1_Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway.pdf by figshare admin frontiersin (4545187)

“…Combining network pharmacology prediction analysis with our validation data from animal models and colonic organoids, we demonstrated that Cyn significantly inhibits IEC apoptosis, as indicated by a decrease in the proportion of TUNEL-positive cells and changes in apoptosis-related protein levels. …”

Data Sheet 1_Crosstalk between MSC-extracellular vesicles and Olea europaea leaf extract in encapsulated liposomal hydrogel: attenuation of neuroinflammation and brain neurotransmi... by Doaa Ibrahim (12910718)

“…The findings of this study demonstrated that the neuroprotective effect of the combined Lipo-OLE-Hydrogel and MSC-Exo treatment was associated with a significant reduction in oxidative stress, as evidenced by the restoration of total antioxidant capacity and the marked decrease in oxidative biomarkers, including reactive oxygen species (ROS), H₂O₂, and malondialdehyde (MDA). …”

Table 1_Association between sedentary behavior, physical activity, and osteoarthritis: results from NHANES 2007–2020 and Mendelian randomization analysis.xls by Jiangqin He (18852987)

“…A U-shaped relationship was observed between PA and OA risk, with a decrease in OA incidence as PA levels increased, although the protective effect of PA was less pronounced in individuals with severe SB. …”

Table 2_Association between sedentary behavior, physical activity, and osteoarthritis: results from NHANES 2007–2020 and Mendelian randomization analysis.xls by Jiangqin He (18852987)

“…A U-shaped relationship was observed between PA and OA risk, with a decrease in OA incidence as PA levels increased, although the protective effect of PA was less pronounced in individuals with severe SB. …”

Data Sheet 2_Characterization and immunoprotection of thioredoxin reductase TrxB knockout mutant of Salmonella Enteritidis.pdf by Siping Zhu (607538)

“…We also observed a significant decrease in the expression of virulence-related genes in the trxB-knockout mutant. …”

Image 1_Spawning habitat selection in Schizothorax wangchiachii using acoustic tagging and tracking.png by Bo Li (112195)

“…Random Forest-based importance analysis indicated that fluvial substrate composition and surface flow velocity were the key predictive variables for habitat selection model with MeanDecreaseGini being 23.3% and 22.6%, respectively.</p>Significance<p>These findings provide quantitative criteria for restoring natural spawning grounds and optimizing ecological operation strategies to support S. wangchiachii conservation in the lower Jinsha River.…”

Data Sheet 4_Characterization and immunoprotection of thioredoxin reductase TrxB knockout mutant of Salmonella Enteritidis.pdf by Siping Zhu (607538)

“…We also observed a significant decrease in the expression of virulence-related genes in the trxB-knockout mutant. …”

Data Sheet 3_Characterization and immunoprotection of thioredoxin reductase TrxB knockout mutant of Salmonella Enteritidis.pdf by Siping Zhu (607538)

“…We also observed a significant decrease in the expression of virulence-related genes in the trxB-knockout mutant. …”