Table 2_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.xlsx by Zhenyu Zhao (737165)

“…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…”

Table 3_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.xlsx by Zhenyu Zhao (737165)

“…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…”

Data Sheet 1_Gut microbiota is involved in the exacerbation of adrenal glucocorticoid steroidogenesis in diabetic animals by activation of the TLR4 pathway.pdf by Nathalia Santos Magalhães (14131047)

“…Furthermore, both TLR4 antagonist and TLR4 mutant mice (C3H/HeJ) induced a significant reduction in plasma corticosterone levels in diabetic mice.…”

Table 1_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.xlsx by Zhenyu Zhao (737165)

“…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…”

Table 6_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.csv by Zhenyu Zhao (737165)

“…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…”

Table 1_BNIP3-mediated mitophagy aggravates placental injury in preeclampsia via NLRP1 inflammasome.docx by Man Zhao (314232)

“…Furthermore, silencing BNIP3 leads to a significant reduction in mitochondrial damage and mtROS production. …”

Table 1_Decadal-scale urban footprints on seagrass blue carbon dynamics in Palk Bay, India: a remote sensing based framework.docx by Rajamohanan Pillai Ranith (22589207)

“…For the built-up areas, this correlates with elevated suspended sediment matter (SSM) (31.2% increase in high urban sites), reductions in seagrass above-ground biomass (AGB: -25.52% of high urban sites), and decreased sediment organic carbon (SOC: -42.67%). …”

Dynamic visualization of DNA methylation in cell cycle genes during iPSC cardiac differentiation by Ning Li (45258)

“…Cdk1 GMR reporter signal was strong in undifferentiated iPSCs, and gradually decreased during cardiomyocyte differentiation. RT-qPCR and pyrosequencing demonstrated that the reduction of <i>Sox2</i> and <i>Cdk1</i> was regulated by hypermethylation of their promoters’ CpG regions during cardiac differentiation.…”

Table 5_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.csv by Zhenyu Zhao (737165)

“…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…”

Table 8_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.csv by Zhenyu Zhao (737165)

“…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…”

Table 3_Comparative study of flow rate- and material-dependent human plasma protein adsorption on oxygenator membranes and heat exchanger materials.pdf by Katharina Große-Berkenbusch (21559466)

“…Protein adsorption to the membrane types did not vary to a large extent, but a decreased flow rate significantly reduced the differences in protein adsorption between both membrane types and led to the adhesion of significantly higher amounts of inhibitory proteins C1INH and α1-AT. …”

Appendix 2 - Tools and Outcomes from the Hybrid Roleplay Intervention by Dinus Salam (20306184)

“…Additionally, the NASA Task Load Index (NASA-TLX) results revealed significant reductions in mental, temporal, and effort demands, indicating a decreased cognitive load during documentation tasks. …”

Data Sheet 1_Effect of Medicaid accountable care on preventable emergency department and hospital admissions: rural-urban heterogeneity.pdf by Jangho Yoon (13258614)

“…</p>Conclusions<p>The CCO model led to significant overall reductions in preventable ED visits. …”

Data Sheet 1_Disease burden of tuberculosis in China from 1990 to 2021 and its prediction to 2036.docx by Rong Sun (532754)

“…</p>Conclusion<p>TB burden in China has decreased significantly overall in the past years. …”

Path regulates glial proliferation via the mTOR-S6K pathway. by Qian Dong (414788)

“…Path downregulation and defects in BBB expansion consequently led to a decrease in brain AAs, such as Leu, which hinders brain tumor protein synthesis to slow down tumor growth. …”

Table 1_Research on the impact of graphene oxide in feed on growth and health parameters in calves.xlsx by Tereza Aulichova (9411673)

“…Additionally, GPx activity was significantly decreased in the GO group (p = 0.011). …”

S1_Figure.pdf by George Brooks (21579206)

“…We observed no age-associated changes in coupling efficiency (ADP:O) of mitochondrial reticulum preparations, but respiratory control (RCR) was decreased in older mice. Additionally, older skeletal muscle exhibited subtle yet significant reductions in the expression of proteins functionally related to substrate uptake and oxidation (mMCT1, mPC1, CPT1b, HADH). …”

Image 1_Effects of dietary fiber on Chinese children with functional constipation and targeted modification of gut microbiota and related metabolites.pdf by Pei Xiao (466657)

“…Scores for abdominal pain, bloating, and straining showed significant reductions. After 4 weeks of dietary fiber treatment, both richness and diversity of gut microbiota were significantly enhanced. …”

Supplementary file 1_Cell wall modulation by drought and elevated CO2 in sugarcane leaves.docx by Alexandre Junio Borges Araujo (12977867)

“…Under eCO₂, cell wall composition was altered, with reductions in glucose and uronic acid in specific fractions, indicating decreased mixed-linkage glucan (MLG) and pectin. …”

Image 2_NET-EN treatment leads to delayed HSV-2 infection, enhanced mucin and T cell functions in the female genital tract when compared to DMPA in a preclinical mouse model.tiff by M. Firoz Mian (10013314)

“…However, DMPA significantly decreased the total number of VT CD4+ and CD8+ T cells and the number of IFN-γ producing CD4 and CD8 T cells and increased the percentage of CD4 and CD8 T cells producing TNF-α compared to untreated mice. …”