Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…Postmenopausal osteoporosis (PMO) is characterized by an imbalance in bone remodeling with increased osteoclast and decreased osteoblast activity, leading to bone loss and higher fracture risk. …”

Raw data. by Changzhi Liu (518454)

“…Restricted cubic spline analysis further demonstrated that the risk of vertebral fractures decreased as the RC level and the RC-to-cholesterol ratio increased. …”

Baseline characteristics of the subjects. by Changzhi Liu (518454)

“…Restricted cubic spline analysis further demonstrated that the risk of vertebral fractures decreased as the RC level and the RC-to-cholesterol ratio increased. …”

Calibration of standards. by Asif Khan (1740271)

“…<i>erecta</i> may be a promising medicinal agent for reducing the risk and progression of Parkinson’s disease.</p></div>…”

Appearance of standards under UV 365 nm. by Asif Khan (1740271)

“…<i>erecta</i> may be a promising medicinal agent for reducing the risk and progression of Parkinson’s disease.</p></div>…”

HPLC-Chromatogram of methanol fraction. by Asif Khan (1740271)

“…<i>erecta</i> may be a promising medicinal agent for reducing the risk and progression of Parkinson’s disease.</p></div>…”

Effects of <i>B</i>.<i>erecta</i> on kidney profile test. by Asif Khan (1740271)

“…<i>erecta</i> may be a promising medicinal agent for reducing the risk and progression of Parkinson’s disease.</p></div>…”

Effects of <i>B</i>.<i>erecta</i> on Morris water maze test. by Asif Khan (1740271)

“…<i>erecta</i> may be a promising medicinal agent for reducing the risk and progression of Parkinson’s disease.</p></div>…”

Characteristics of the included studies. by Si He (3236646)

“…The overall results revealed that NPWT significantly decreased the sternal wound reinfection (SWRI) rate (RR [95% CI] = 0.179 [0.099 to 0.323], 95% prediction interval [PI]: 0.082 to 0.442), in-hospital mortality (RR [95% CI] = 0.242 [0.149 to 0.394], 95% PI: 0.144 to 0.461), and shortened the length of intensive care unit (ICU) stay (SMD [95% CI] = −0.601 [−0.820 to −0.382], 95% PI: −1.317 to 0.128) compared with conventional wound care. …”

Effects of <i>B</i>.<i>erecta</i> on liver profile test. by Asif Khan (1740271)

“…<i>erecta</i> may be a promising medicinal agent for reducing the risk and progression of Parkinson’s disease.</p></div>…”

Extracted data and used for analysis. by Si He (3236646)

“…The overall results revealed that NPWT significantly decreased the sternal wound reinfection (SWRI) rate (RR [95% CI] = 0.179 [0.099 to 0.323], 95% prediction interval [PI]: 0.082 to 0.442), in-hospital mortality (RR [95% CI] = 0.242 [0.149 to 0.394], 95% PI: 0.144 to 0.461), and shortened the length of intensive care unit (ICU) stay (SMD [95% CI] = −0.601 [−0.820 to −0.382], 95% PI: −1.317 to 0.128) compared with conventional wound care. …”

Excluded studies with reasons for exclusion. by Si He (3236646)

“…The overall results revealed that NPWT significantly decreased the sternal wound reinfection (SWRI) rate (RR [95% CI] = 0.179 [0.099 to 0.323], 95% prediction interval [PI]: 0.082 to 0.442), in-hospital mortality (RR [95% CI] = 0.242 [0.149 to 0.394], 95% PI: 0.144 to 0.461), and shortened the length of intensive care unit (ICU) stay (SMD [95% CI] = −0.601 [−0.820 to −0.382], 95% PI: −1.317 to 0.128) compared with conventional wound care. …”

Predictors of SCD. by Iftikhar Ali Ch (20783753)

“…<div><p> Background </p><p>While coronary artery bypass grafting (CABG) surgery is effective in reducing the risk of myocardial infarction and subsequent cardiac events by improving myocardial perfusion, the risk of sudden cardiac death (SCD) remains notable.…”

Clinical outcomes. by Iftikhar Ali Ch (20783753)

“…<div><p> Background </p><p>While coronary artery bypass grafting (CABG) surgery is effective in reducing the risk of myocardial infarction and subsequent cardiac events by improving myocardial perfusion, the risk of sudden cardiac death (SCD) remains notable.…”

Obesity and Depressed Ejection Fraction. by Iftikhar Ali Ch (20783753)

“…<div><p> Background </p><p>While coronary artery bypass grafting (CABG) surgery is effective in reducing the risk of myocardial infarction and subsequent cardiac events by improving myocardial perfusion, the risk of sudden cardiac death (SCD) remains notable.…”

Kaplan Meier curve. by Iftikhar Ali Ch (20783753)

“…<div><p> Background </p><p>While coronary artery bypass grafting (CABG) surgery is effective in reducing the risk of myocardial infarction and subsequent cardiac events by improving myocardial perfusion, the risk of sudden cardiac death (SCD) remains notable.…”

Anthelmintics Derived from the Kinase Inhibitor SGI-1776 for the Treatment of Gastrointestinal Worm Infections by Mostafa A. Elfawal (22430138)

“…The compounds’ physical properties were significantly predictive of their activity. <b>15</b> and <b>51</b> were the most potent against whipworm and showed decreased and no activity against human PIM kinases, suggesting increased selectivity against the GIN counterparts. …”

Baseline characteristics. by Daniela Sánchez-Santiesteban (21192342)

“…After adjusting for confounders, individuals in the highest quartile had a 25% lower risk of death than those in the lowest quartile (aHR: 0.74; 95% CI: 0.59–0.92). …”

Risk factors for ACS (multivariate analysis). by Mohamed Condé (22622306)

“…Increased use of opiates in the Emergency Department, elevated total leucocyte count, breath rate, and decreased red blood cell count were not significantly associated with ACS occurrence (p > 0.05). …”

Trends in ESR per survey round by age group. by Alex Daama (18351052)

“…<div><p>Introduction</p><p>Voluntary medical male circumcision (VMMC) reduces the risk of heterosexual acquisition of HIV by 50%–60%. …”