Image 4_Single-cell and spatial transcriptomics reveal correlation between RNA methylation-related miRNA risk model and immune infiltration in hepatocellular carcinoma.tif by Rong Su (2210740)

“…The data integration of scRNA-seq and bulk RNA-seq showed the decreased TIDE score in the high-risk patients and the elevated levels of Macro-secreted phosphoprotein 1 (SPP1), MDSC-meiotic nuclear divisions 1 (MND1), γδ T cells, and Macro-complement C1q C chain (C1QC) predicted adverse prognosis. …”

Table 1_Single-cell and spatial transcriptomics reveal correlation between RNA methylation-related miRNA risk model and immune infiltration in hepatocellular carcinoma.xlsx by Rong Su (2210740)

“…The data integration of scRNA-seq and bulk RNA-seq showed the decreased TIDE score in the high-risk patients and the elevated levels of Macro-secreted phosphoprotein 1 (SPP1), MDSC-meiotic nuclear divisions 1 (MND1), γδ T cells, and Macro-complement C1q C chain (C1QC) predicted adverse prognosis. …”

Data Sheet 1_Global burden of Type 2 Diabetes Mellitus attributable to dietary risks in elderly adults: insights from the Global Burden of Disease study 2021.docx by Yiting Tang (2295307)

“…</p>Conclusion<p>This study underscores the substantial burden of T2DM attributable to dietary risks among elderly adults and highlights significant regional and demographic disparities. …”

Table 2_Prognostic alternative mRNA splicing in lung adenocarcinoma.xlsx by Panke Su (22636301)

“…</p>Results<p>A total of 13 PASEs were selected to form the prognostic signature, which demonstrated excellent predictive power for 1-, 2-, and 3-year overall survival (OS), with area under the receiver operating characteristic curve values of 0.776, 0.751, and 0.767, respectively. High-risk patients, identified by the signature, showed significantly decreased stromal, immune, and combined scores; increased tumor purity (P< 0.001); a reduced prevalence of various immune cell types; diminished immune cell activity; and decreased expression of immune checkpoint genes. …”

Data Sheet 1_Prognostic alternative mRNA splicing in lung adenocarcinoma.xlsx by Panke Su (22636301)

“…</p>Results<p>A total of 13 PASEs were selected to form the prognostic signature, which demonstrated excellent predictive power for 1-, 2-, and 3-year overall survival (OS), with area under the receiver operating characteristic curve values of 0.776, 0.751, and 0.767, respectively. High-risk patients, identified by the signature, showed significantly decreased stromal, immune, and combined scores; increased tumor purity (P< 0.001); a reduced prevalence of various immune cell types; diminished immune cell activity; and decreased expression of immune checkpoint genes. …”

Table 1_Prognostic alternative mRNA splicing in lung adenocarcinoma.xlsx by Panke Su (22636301)

“…</p>Results<p>A total of 13 PASEs were selected to form the prognostic signature, which demonstrated excellent predictive power for 1-, 2-, and 3-year overall survival (OS), with area under the receiver operating characteristic curve values of 0.776, 0.751, and 0.767, respectively. High-risk patients, identified by the signature, showed significantly decreased stromal, immune, and combined scores; increased tumor purity (P< 0.001); a reduced prevalence of various immune cell types; diminished immune cell activity; and decreased expression of immune checkpoint genes. …”

Beta cell function derived from routine clinical measures reports and predicts treatment response to immunotherapy in recent-onset type 1 diabetes. by Michelle So (400874)

Data Sheet 1_The impact of social activity on cardiovascular disease risk among middle-aged and older adults in China: a nationwide cohort study based on the CHARLS database.pdf by Yingting Wu (12215218)

“…</p>Conclusion<p>Social activity is significantly linked to the risk of cardiovascular disease among middle-aged and older adults in China. …”

Data Sheet 1_Comprehensive analysis of metabolism-related genes in sepsis reveals metabolic–immune heterogeneity and highlights GYG1 as a potential therapeutic target.csv by Jie Zheng (31208)

“…In vivo, Gyg1 was markedly upregulated in septic mice, and LNP-mediated siRNA knockdown of Gyg1 significantly improved survival in the LPS model. Mechanistically, Gyg1 knockdown significantly reduced glycogen content in myeloid cells, attenuated IL-6 and TNF-α production, alleviated LPS-induced neutrophil, and modestly decreased CD40 expression in monocytes and dendritic cells. …”

Table 1_Composition of peripheral blood immune cell compartment in stage 5 chronic kidney disease is affected by smoking and other risk factors associated with systemic inflammator... by Ivan Zahradka (17004510)

“…PERMANOVA identified smoking, CMV seropositivity, age, dialysis treatment, and atherosclerotic cardiovascular disease as factors significantly influencing peripheral blood immune composition. …”

Non-consumptive effects of <i>Cyrtorhinus lividipennis</i> (Hemiptera: Miridae) on development, wing dimorphism, and reproduction in <i>Sogatella furcifera</i> (Hemiptera: Delphaci... by Meng Yang (162251)

“…Further analysis of physiological indices showed that key genes involved in wing-morph switching and ecdysone (20E) synthesis were downregulated after exposure to predation risk, accompanied by a significant decrease in the 20E titre in the 4th instar, which may represent a potential regulatory mechanism of planthoppers in response to predator stress. …”

Data Sheet 1_Global, regional, and national epidemiology of Intracerebral Hemorrhage among women of childbearing age (1990–2021): incidence, mortality, DALYs, and risk factor analy... by Yuan Li (67017)

“…Background and Objectives<p>Intracerebral Hemorrhage (ICH) is a serious cerebrovascular condition that poses a significant health risk to women of childbearing age (WCBA) globally. …”

Thousands of chromatin regions show changes in accessibility in response to TOP2i treatment. by E. Renee Matthews (18071587)

Table 1_The relationship between positive future thinking, entrapment, defeat and death-related mental imagery in individuals with and without a suicidal history: an experimental s... by Gonca Köse (21477470)

“…Mean scores for PFT from pre-to post-negative mood induction decreased significantly in the participants with a history of suicidal thoughts/behaviours but not in those without a suicidal history. …”

Table 1_Regional and age-specific global trends associated with infectious diarrhea in children under 14 years old caused by pathogenic microorganisms in 2021.docx by Tuanjie Wang (6619406)

“…</p>Conclusion<p>Although the global burden of diarrhea has decreased significantly, it is still high in low-income countries and low- and medium-SDI areas, and newborns are at high risk. …”

Supplementary file 1_Burden of ageing spectrum of diseases in China, 1990–2021: a systematic analysis of global burden of disease study 2021.pdf by Li Yang (6520)

“…Additionally, notable changes in COVID-19-related DALYs became evident beginning in 2019. Regarding risk factors, particulate matter pollution, smoking, and high sodium diets emerged as the top three contributors to health risks among the older adults.…”

Table 4_Global burden of low back pain and its attributable risk factors from 1990 to 2021: a comprehensive analysis from the global burden of disease study 2021.docx by Yue Li (102191)

“…Compared with 1990, although the ASIR and age-standardized disability-adjusted life years rate (ASDALYsR) decreased, absolute numbers increased significantly. …”

Table 1_Global burden of low back pain and its attributable risk factors from 1990 to 2021: a comprehensive analysis from the global burden of disease study 2021.docx by Yue Li (102191)

“…Compared with 1990, although the ASIR and age-standardized disability-adjusted life years rate (ASDALYsR) decreased, absolute numbers increased significantly. …”

Table 3_Global burden of low back pain and its attributable risk factors from 1990 to 2021: a comprehensive analysis from the global burden of disease study 2021.docx by Yue Li (102191)

“…Compared with 1990, although the ASIR and age-standardized disability-adjusted life years rate (ASDALYsR) decreased, absolute numbers increased significantly. …”

Table 2_Global burden of low back pain and its attributable risk factors from 1990 to 2021: a comprehensive analysis from the global burden of disease study 2021.docx by Yue Li (102191)

“…Compared with 1990, although the ASIR and age-standardized disability-adjusted life years rate (ASDALYsR) decreased, absolute numbers increased significantly. …”