Data Sheet 1_IFNβ drives ferroptosis through elevating TRIM22 and promotes the cytotoxicity of RSL3.pdf by Huiyue Dong (4808436)

“…</p>Conclusions<p>Our work reveals a role for IFNβ in promoting ferroptosis and provides evidence that IFNβ could be used with RSL3 to increase cytotoxic effects in tumor cells.…”

Image3_DNA methylation-mediated FGFR1 silencing enhances NF-κB signaling: implications for asthma pathogenesis.TIF by Minglu Meng (19725085)

“…Background<p>Fibroblast growth factor receptor 1 (FGFR1) is known to play a crucial role in the pathogenesis of asthma, although the precise mechanism remains unclear. …”

Image2_DNA methylation-mediated FGFR1 silencing enhances NF-κB signaling: implications for asthma pathogenesis.TIF by Minglu Meng (19725085)

“…Background<p>Fibroblast growth factor receptor 1 (FGFR1) is known to play a crucial role in the pathogenesis of asthma, although the precise mechanism remains unclear. …”

Data Sheet 2_IFNβ drives ferroptosis through elevating TRIM22 and promotes the cytotoxicity of RSL3.pdf by Huiyue Dong (4808436)

“…</p>Conclusions<p>Our work reveals a role for IFNβ in promoting ferroptosis and provides evidence that IFNβ could be used with RSL3 to increase cytotoxic effects in tumor cells.…”

Data_Sheet_1_Causal relationship between non-alcoholic fatty liver disease and sarcopenia: a bidirectional Mendelian randomization study.PDF by Meng Chen (48769)

“…Published summary statistics were used to obtain instrumental variables (IVs) at the genome-wide significance level.</p>Results<p>IVW analysis showed that the risk of NAFLD was reduced when walking pace was increased (OR = 0.435, 95%CI 0.240–0.789, p = 0.006); Increasing appendicular lean mass (ALM) decreased the risk of NAFLD (OR = 0.906, 95%CI 0.838–0.980, p = 0.014); Those older than 60 were more likely to suffer from NAFLD if they had low grip strength (OR = 1.411, 95%CI 1.087–1.830, p = 0.0012). …”

Image 1_Morc4 is a novel functional gene associated with lipid metabolism in BXD recombinant inbred population.pdf by Zhanyi Yang (5142182)

“…In hepatocytes, MORC4 knockdown significantly elevated total TC/TG levels, as well as enhanced lipid accumulation. …”

Table_1_Causal relationship between non-alcoholic fatty liver disease and sarcopenia: a bidirectional Mendelian randomization study.DOCX by Meng Chen (48769)

“…Published summary statistics were used to obtain instrumental variables (IVs) at the genome-wide significance level.</p>Results<p>IVW analysis showed that the risk of NAFLD was reduced when walking pace was increased (OR = 0.435, 95%CI 0.240–0.789, p = 0.006); Increasing appendicular lean mass (ALM) decreased the risk of NAFLD (OR = 0.906, 95%CI 0.838–0.980, p = 0.014); Those older than 60 were more likely to suffer from NAFLD if they had low grip strength (OR = 1.411, 95%CI 1.087–1.830, p = 0.0012). …”

Image1_DNA methylation-mediated FGFR1 silencing enhances NF-κB signaling: implications for asthma pathogenesis.TIF by Minglu Meng (19725085)

“…Background<p>Fibroblast growth factor receptor 1 (FGFR1) is known to play a crucial role in the pathogenesis of asthma, although the precise mechanism remains unclear. …”

Table 1_Morc4 is a novel functional gene associated with lipid metabolism in BXD recombinant inbred population.xlsx by Zhanyi Yang (5142182)

“…In hepatocytes, MORC4 knockdown significantly elevated total TC/TG levels, as well as enhanced lipid accumulation. …”

Image 2_Spatial deciphering of the transcriptomic heterogeneity of tumor spread through air spaces in lung cancer.tif by Wenhao Wang (515852)

“…</p>Results<p>Compared with tumor nests in non-STAS patients, HLA-DRB5 and RASGRF1 were significantly less expressed in compartments of STAS, suggesting their inhibitory roles in the occurrence of STAS. …”

Image 4_Spatial deciphering of the transcriptomic heterogeneity of tumor spread through air spaces in lung cancer.tif by Wenhao Wang (515852)

“…</p>Results<p>Compared with tumor nests in non-STAS patients, HLA-DRB5 and RASGRF1 were significantly less expressed in compartments of STAS, suggesting their inhibitory roles in the occurrence of STAS. …”

Data Sheet 1_Spatial deciphering of the transcriptomic heterogeneity of tumor spread through air spaces in lung cancer.zip by Wenhao Wang (515852)

“…</p>Results<p>Compared with tumor nests in non-STAS patients, HLA-DRB5 and RASGRF1 were significantly less expressed in compartments of STAS, suggesting their inhibitory roles in the occurrence of STAS. …”

Image 1_Spatial deciphering of the transcriptomic heterogeneity of tumor spread through air spaces in lung cancer.tif by Wenhao Wang (515852)

“…</p>Results<p>Compared with tumor nests in non-STAS patients, HLA-DRB5 and RASGRF1 were significantly less expressed in compartments of STAS, suggesting their inhibitory roles in the occurrence of STAS. …”

Image 3_Spatial deciphering of the transcriptomic heterogeneity of tumor spread through air spaces in lung cancer.tif by Wenhao Wang (515852)

“…</p>Results<p>Compared with tumor nests in non-STAS patients, HLA-DRB5 and RASGRF1 were significantly less expressed in compartments of STAS, suggesting their inhibitory roles in the occurrence of STAS. …”

Dataset: Foraminiferal denitrification and deep bioirrigation influence benthic biogeochemical cycling in a seasonally hypoxic fjord by Subhadeep Rakshit (19702714)

“…</p><p dir="ltr">Abstract of the paper: </p><p dir="ltr">Benthic macro- and micro-biota often play significant roles in controlling the biogeochemical dynamics in sediments. …”

Data Sheet 1_Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study.pdf by Kaiwen Wang (838527)

“…</p>Results<p>There was no causal relationship between sex hormones and IBD in women (P > 0.05), and there was a causal and positive correlation between SHBG and testosterone and IBD in men.The OR for SHBG was 1.22 (95% CI: 1.09-1.37, P = 0.0004), and for testosterone was 1.20 (95% CI: 1.04-1.39, P = 0.0145).IBD did not significantly interact with female sex hormones but resulted in a decrease in SHBG (OR = 1.02, 95% CI: 1.00-1.04, P = 0.0195) and testosterone (OR = 1.01, 95% CI: 1.00 -1.02, P = 0.0200) in men.…”

Data Sheet 1_Study on the function of TTG1 gene in Camellia oleifera.docx by Chengcheng Xiang (5512442)

“…Heterologous expression resulted in: (1) significantly increased leaf trichome density (up to 114 trichomes/50 mm²); (2) enhanced seed anthocyanin accumulation (199–318% increase); and (3) substantial alterations in fatty acid composition, including 79% elevation in oleic acid (C18:1), 113% increase in gondoic acid (C20:1), 35% reduction in both linolenic (C18:3) and palmitic acids (C16:0), and 87% decrease in erucic acid (C22:1). …”

Table 1_Petunidin alleviates diabetic nephropathy injury via the inhibition of oxidative stress and ferroptosis through the Keap1/mitoNQO1 pathway.docx by Yuli Qiu (21758906)

“…</p>Results<p>Keap1 expression in the kidneys of db/db mice was significantly increased, along with reduced mitochondrial translocation of NQO1, while PET reversed this trend to decrease oxidative stress and inhibit ferroptosis. …”

Table 1_Study on the function of TTG1 gene in Camellia oleifera.xlsx by Chengcheng Xiang (5512442)

“…Heterologous expression resulted in: (1) significantly increased leaf trichome density (up to 114 trichomes/50 mm²); (2) enhanced seed anthocyanin accumulation (199–318% increase); and (3) substantial alterations in fatty acid composition, including 79% elevation in oleic acid (C18:1), 113% increase in gondoic acid (C20:1), 35% reduction in both linolenic (C18:3) and palmitic acids (C16:0), and 87% decrease in erucic acid (C22:1). …”

Data Sheet 1_Exploring the glucose-lowering and anti-inflammatory immune mechanism of artemether by AMPK/mTOR pathway and microbiome based on multi-omics.docx by Tao Jiang (28401)

“…</p>Results<p>ATM treatment (160 mg/kg) observably ameliorated insulin resistance (IR), hyperglycemia, hyperlipemia and pathological injury in the liver and pancreas. In addition, ATM significantly decreased the expression of TNF-α, IL-1β, IL-6, NF-κB and IL-17A, and significantly increased the level of IL-10 in diabetic mice. 16S rRNA sequencing and targeted GC-MS metabolomics result indicated that ATM restored gut microbiota dysbiosis based on increasing beneficial bacteria Lactobacillus and reducing pathogenic bacteria Helicobacter and Prevotella leading to the accumulation of propionic and valeric acids and the reduction of lipopolysaccharides (LPS) release, intestinal inflammation and intestinal barrier damage. …”