Data Sheet 1_Gut microbiota is involved in the exacerbation of adrenal glucocorticoid steroidogenesis in diabetic animals by activation of the TLR4 pathway.pdf by Nathalia Santos Magalhães (14131047)

“…We observed morphological alterations as well as increased inflammation in the colon with a predominance of a Th17 cytokine profile in diabetic mice, in parallel to an increase in the epithelial-intestinal permeability and lipopolysaccharide content in the adrenals. TAK-242 significantly decreased the overexpression of adrenocorticotropic hormone receptor and 11β-hydroxysteroid dehydrogenase type 1 in the adrenal glands of diabetic mice. …”

Data Sheet 1_Screening of neurotransmitter receptor modulators reveals novel inhibitors of influenza virus replication.pdf by Yarou Gao (20620991)

“…In a mouse model of lethal influenza, isoxsuprine significantly decreased lung viral titers, mitigated pulmonary inflammation, and enhanced survival rates. …”

Table 1_Coptis japonica Makino ethanol extracts attenuates cancer cachexia induced muscle and fat wasting through inhibition of the STAT3 signaling pathway.docx by Yo Sep Hwang (17967916)

“…Our results demonstrated that CJME significantly decreased the mRNA and protein levels of muscle-specific E3 ubiquitin ligases Atrogin-1 and MuRF1 in myotubes exposed to CT26 CM. …”

Supplementary Materials - Figure by Shaojie Zhang (20807333)

“…<p dir="ltr">Exposure to hypobaric hypoxia during rapid ascent to high altitudes significantly impacts intestinal barrier function. Goblet cells, as one of the primary cell types in the intestinal mucosa, play a crucial role in maintaining this barrier. …”

Supplementary file 3_Heterogeneity and longitudinal transcriptomic characteristics of Tregs in COVID-19 patients.pdf by Yanling Wen (552195)

“…Introduction<p>Regulatory T cells (Tregs) play a crucial role in maintaining immune tolerance by suppressing immune responses against pathogens. …”

Data Sheet 9_Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle.xlsx by Shengyou Song (22391068)

“…The TGF-β/Smad signaling pathway plays a significant role in the development and progression of RCC.…”

Supplementary file 2_Heterogeneity and longitudinal transcriptomic characteristics of Tregs in COVID-19 patients.pdf by Yanling Wen (552195)

“…Introduction<p>Regulatory T cells (Tregs) play a crucial role in maintaining immune tolerance by suppressing immune responses against pathogens. …”

Data Sheet 6_Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle.xlsx by Shengyou Song (22391068)

“…The TGF-β/Smad signaling pathway plays a significant role in the development and progression of RCC.…”

Table 1_BNIP3-mediated mitophagy aggravates placental injury in preeclampsia via NLRP1 inflammasome.docx by Man Zhao (314232)

“…Furthermore, silencing BNIP3 leads to a significant reduction in mitochondrial damage and mtROS production. …”

Image 3_Global, regional, and national burden of acute glomerulonephritis from 1990 to 2021 and future trend predictions until 2036: a systematic analysis using the Global Burden o... by Yangtian Jiao (21725018)

“…Decomposition analysis highlighted the role of epidemiological improvements, balanced by the impacts of population growth and aging. …”

Image 2_Moderate regular physical exercise can help in alleviating the systemic impact of schistosomiasis infection on brain cognitive function.tif by Inssaf Berkiks (15350248)

“…Remarkably, exercise decreased glial cell production of TNFα, suggesting a shift towards a less pro-inflammatory environment. …”

Table 1_Decadal-scale urban footprints on seagrass blue carbon dynamics in Palk Bay, India: a remote sensing based framework.docx by Rajamohanan Pillai Ranith (22589207)

“…Introduction<p>Seagrass ecosystems are vital for carbon sequestration, shoreline stabilization, habitat provision, and nutrient cycling, thereby playing a key role in climate mitigation and adaptation. Understanding how anthropogenic pressures affect seagrass ecosystems is essential for effective coastal zone management.…”

Table 1_Efficacy of the early start Denver model combined with the TEACCH program in children with autism spectrum disorder.docx by Ling-Ling Ma (7894544)

“…Background<p>Early intervention plays a crucial role in improving outcomes for children with autism spectrum disorder (ASD). …”

Data Sheet 1_Unraveling the anti-inflammatory effects of Mediterranean diet in patients with cancer remission.pdf by Michele Francesco Di Tolla (12503167)

“…Low-grade chronic inflammation (LGCI) plays a crucial role in cancer progression and in cardiometabolic diseases. …”

Image3_Seawater temperature drives the diversity of key cyanobacteria (Synechococcus and Prochlorococcus) in a warming sea.tiff by Alexandra Coello-Camba (6489533)

“…<p>The picocyanobacteria genera Prochlorococcus and Synechococcus play a significant role globally, dominating the primary production in warm and oligotrophic tropical and subtropical areas, which represent the largest oceanic ecosystem. …”

Image5_Seawater temperature drives the diversity of key cyanobacteria (Synechococcus and Prochlorococcus) in a warming sea.tiff by Alexandra Coello-Camba (6489533)

“…<p>The picocyanobacteria genera Prochlorococcus and Synechococcus play a significant role globally, dominating the primary production in warm and oligotrophic tropical and subtropical areas, which represent the largest oceanic ecosystem. …”

Image 1_Cancer-associated fibroblasts gene signature: a novel approach to survival prediction and immunotherapy guidance in colon cancer.tif by Wenbing Zhang (152972)

“…A higher immune infiltration rate and lower IC50 values of anticancer drugs were significant in the high-risk group. In cellular experiments, Following MAN1B1 knockdown, in cell assays, the colony formation, migration, and invasion ability of HCT116 and HT29 cell lines decreased.…”

Image 1_Global, regional, and national burden of acute glomerulonephritis from 1990 to 2021 and future trend predictions until 2036: a systematic analysis using the Global Burden o... by Yangtian Jiao (21725018)

“…Decomposition analysis highlighted the role of epidemiological improvements, balanced by the impacts of population growth and aging. …”

Data Sheet 1_Andrographis paniculata restores gut health by suppressing inflammation and strengthening mucosal immunity.pdf by Vidushi Tyagi (14022240)

“…Background<p>Gut immunity plays a critical role in overall health by balancing tolerance to food antigens and microbiota while defending against pathogens. …”

Table 2_Proteomic profiling of peripheral blood mononuclear cells reveals immune dysregulation and metabolic alterations in kidney transplant recipients with COVID-19.xlsx by Giuseppe G. F. Leite (18186056)

“…<p>The COVID-19 pandemic has significantly impacted global health, especially in vulnerable populations like kidney transplant recipients (KTRs). …”