يعرض 3,881 - 3,900 نتائج من 4,114 نتيجة بحث عن '(( significant decrease decrease ) OR ( significant role decrease ))~', وقت الاستعلام: 0.31s تنقيح النتائج
  1. 3881

    Table_1_RETRACTED: miR-335 Targets LRRK2 and Mitigates Inflammation in Parkinson’s Disease.DOCX حسب Sara R. Oliveira (10972152)

    منشور في 2025
    "…LRRK2-Wt-induced proinflammatory gene expression was also significantly reduced by miR-335 overexpression. Finally, in SH-SY5Y neuroblastoma cells, miR-335 decreased the expression of pro-inflammatory genes triggered by α-synuclein. …"
  2. 3882

    Image 1_Interactions between the intestinal microbiome and host genes in regulating vibriosis resistance in Cynoglossus semilaevis.jpeg حسب Weiwei Zheng (140828)

    منشور في 2025
    "…</p>Results<p>Obvious histopathological differences were observed between the resistant and susceptible groups in terms of inflammatory cells infiltration, and tissue dissociation of mucosal layer. 16S rRNA sequencing analysis indicated that Vibrio increased but Stenotrophomonas, Chryseobacterium, Delftia, and Salinivibrio decreased in the susceptible group. Compared to the control group, 1,986 differentially expressed genes (DEGs) were detected in the susceptible group, significantly more than the 310 DEGs found in the resistant group. …"
  3. 3883

    Data Sheet 1_Preventive hyperbaric oxygen therapy improves acute graft-versus-host disease by activating the Nrf2/HO-1 pathway.pdf حسب Chao Xue (503328)

    منشور في 2025
    "…ML385, an Nrf2 inhibitor, was used to validate the protective role of Nrf2 in the beneficial effect of HBOT on aGVHD. …"
  4. 3884

    Table 9_Interactions between the intestinal microbiome and host genes in regulating vibriosis resistance in Cynoglossus semilaevis.xlsx حسب Weiwei Zheng (140828)

    منشور في 2025
    "…</p>Results<p>Obvious histopathological differences were observed between the resistant and susceptible groups in terms of inflammatory cells infiltration, and tissue dissociation of mucosal layer. 16S rRNA sequencing analysis indicated that Vibrio increased but Stenotrophomonas, Chryseobacterium, Delftia, and Salinivibrio decreased in the susceptible group. Compared to the control group, 1,986 differentially expressed genes (DEGs) were detected in the susceptible group, significantly more than the 310 DEGs found in the resistant group. …"
  5. 3885
  6. 3886

    Data Sheet 1_Unveiling the anti-inflammatory potential of olive leaf phenolic extracts in diabetes-related endothelial dysfunction.docx حسب Ilaria Cappellacci (12997431)

    منشور في 2025
    "…VCAM-1 protein expression and TNFα-induced monocyte adhesion were also significantly decreased following extract treatment. …"
  7. 3887

    DataSheet1_Sodium danshensu modulates skeletal muscle fiber type formation and metabolism by inhibiting pyruvate kinase M1.docx حسب Yunxia Zhang (30848)

    منشور في 2024
    "…Muscle mass, the percentage of slow oxidative fibers, succinic dehydrogenase activity, muscle endurance, glucose tolerance, and the expression of the MyHC1 and MyHC2a genes increased while MyHC2b expression, lactate dehydrogenase activity, and the percentage of glycolytic muscle fibers decreased in SDSS-treated mice. Mechanistically, SDSS bound to the pyruvate kinase PKM1 and significantly repressed its activity. …"
  8. 3888

    Image 1_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif حسب Toru Miwa (8528715)

    منشور في 2025
    "…Auditory brainstem response (ABR) thresholds were significantly elevated, and distortion-product otoacoustic emissions (DPOAE) indicated outer hair cell dysfunction. …"
  9. 3889

    Table 8_Interactions between the intestinal microbiome and host genes in regulating vibriosis resistance in Cynoglossus semilaevis.xlsx حسب Weiwei Zheng (140828)

    منشور في 2025
    "…</p>Results<p>Obvious histopathological differences were observed between the resistant and susceptible groups in terms of inflammatory cells infiltration, and tissue dissociation of mucosal layer. 16S rRNA sequencing analysis indicated that Vibrio increased but Stenotrophomonas, Chryseobacterium, Delftia, and Salinivibrio decreased in the susceptible group. Compared to the control group, 1,986 differentially expressed genes (DEGs) were detected in the susceptible group, significantly more than the 310 DEGs found in the resistant group. …"
  10. 3890

    Table 6_Interactions between the intestinal microbiome and host genes in regulating vibriosis resistance in Cynoglossus semilaevis.xlsx حسب Weiwei Zheng (140828)

    منشور في 2025
    "…</p>Results<p>Obvious histopathological differences were observed between the resistant and susceptible groups in terms of inflammatory cells infiltration, and tissue dissociation of mucosal layer. 16S rRNA sequencing analysis indicated that Vibrio increased but Stenotrophomonas, Chryseobacterium, Delftia, and Salinivibrio decreased in the susceptible group. Compared to the control group, 1,986 differentially expressed genes (DEGs) were detected in the susceptible group, significantly more than the 310 DEGs found in the resistant group. …"
  11. 3891

    Table 7_Interactions between the intestinal microbiome and host genes in regulating vibriosis resistance in Cynoglossus semilaevis.xlsx حسب Weiwei Zheng (140828)

    منشور في 2025
    "…</p>Results<p>Obvious histopathological differences were observed between the resistant and susceptible groups in terms of inflammatory cells infiltration, and tissue dissociation of mucosal layer. 16S rRNA sequencing analysis indicated that Vibrio increased but Stenotrophomonas, Chryseobacterium, Delftia, and Salinivibrio decreased in the susceptible group. Compared to the control group, 1,986 differentially expressed genes (DEGs) were detected in the susceptible group, significantly more than the 310 DEGs found in the resistant group. …"
  12. 3892

    Image 4_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif حسب Toru Miwa (8528715)

    منشور في 2025
    "…Auditory brainstem response (ABR) thresholds were significantly elevated, and distortion-product otoacoustic emissions (DPOAE) indicated outer hair cell dysfunction. …"
  13. 3893

    Table 3_Interactions between the intestinal microbiome and host genes in regulating vibriosis resistance in Cynoglossus semilaevis.xlsx حسب Weiwei Zheng (140828)

    منشور في 2025
    "…</p>Results<p>Obvious histopathological differences were observed between the resistant and susceptible groups in terms of inflammatory cells infiltration, and tissue dissociation of mucosal layer. 16S rRNA sequencing analysis indicated that Vibrio increased but Stenotrophomonas, Chryseobacterium, Delftia, and Salinivibrio decreased in the susceptible group. Compared to the control group, 1,986 differentially expressed genes (DEGs) were detected in the susceptible group, significantly more than the 310 DEGs found in the resistant group. …"
  14. 3894

    Unveiling the molecular legacy of transient insulin resistance: Implications for hepatic metabolic adaptability (Sup Tables). Berthier et al. J. Hepatol. 2025 حسب Alexandre Berthier (16876311)

    منشور في 2025
    "…<h2>Abstract</h2><h3>Background & Aims</h3><p dir="ltr">Insulin plays a central role in coordinating metabolic flexibility (MetF). …"
  15. 3895

    Table 1_Integrated physiological and transcriptomic analyses elucidate the molecular mechanisms of exogenous melatonin-mediated salt tolerance in pomegranate (Punica granatum L.).x... حسب Yuanling Yang (22524785)

    منشور في 2025
    "…In contrast, 400 μM MT treatment effectively mitigated oxidative damage by coordinated activation of superoxide dismutase (SOD,+14.3%), peroxidase (POD,+21.7%), and catalase (CAT,+11.7%) activities, thereby stabilizing membrane integrity. Furthermore, MT significantly alleviated photoinhibition: F<sub>V</sub>/F<sub>M</sub> increased by 39%, Y<sub>II</sub> and qP rose, and NPQ decreased compared to salt-stressed plants, reflecting enhanced protection of the PSII reaction center and optimized light energy allocation. …"
  16. 3896

    Data Sheet 1_Premature renal epithelial cell senescence promoted by LXN/Rps3/p53 signaling pathway activation increases calcium oxalate crystal deposition by altering macrophage po... حسب Maolin Chu (11611507)

    منشور في 2025
    "…Furthermore, reducing cellular LXN/Rps3/p53 signaling significantly decreased SASP factors in the culture medium and simultaneously abolished M1-like phenotype macrophage polarization. …"
  17. 3897

    Data Sheet 1_Inflammation-related biomarkers and berberine therapy in post-stroke depression: evidence from bioinformatics, machine learning, and experimental validation.docx حسب Wei Liu (20030)

    منشور في 2025
    "…Objective<p>Post-stroke depression (PSD), a common neuropsychiatric complication, significantly hinders stroke recovery and quality of life. …"
  18. 3898

    Data Sheet 1_Determination of nine prostaglandins in the arachidonic acid metabolic pathway with UHPLC-QQQ-MS/MS and application to in vitro and in vivo inflammation models.docx حسب Yufeng Huang (782683)

    منشور في 2025
    "…At the same time, the levels of these PGs decreased significantly (p < 0.01 vs. LPS-induced group) after the positive drug (dexamethasone) intervention. …"
  19. 3899

    Supplementary file 1_Embryo-derived trypsin-induced calcium entry is inhibited by endometrial infertility factor, LEFTY2.docx حسب Zhiqi Yang (2692909)

    منشور في 2025
    "…In the presence of nifedipine, LEFTY2 did not further modify trypsin induced increase of [Ca<sup>2+</sup>]<sub>i</sub>. LEFTY2 significantly decreased levels of L-type Ca<sup>2+</sup> channel.…"
  20. 3900

    Table 1_Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction.xlsx حسب Jingjing Chen (293564)

    منشور في 2025
    "…</p>Results<p>We identified 25 ribosome biogenesis-related differentially expressed genes, which were significantly enriched in RNA degradation and rRNA processing. …"