Supplementary file 1_Histopathological examination and transcriptomic profiling reveal gossypol toxicity-responsive genes related to fertility in mice.docx حسب Teame Gereziher Mehari (11253141)

"…Introduction<p>Gossypol impairs reproduction in both sexes, inducing mitochondrial dysfunction, irregular cycles, and fewer ovarian follicles, leading to decreased fertility rates. …"

Supplementary Material for: High-sensitivity Troponin I Measurement in a Large Contemporary Cohort: Implications for Clinical Care حسب Esau D. (20563829)

"…Male sex, higher HDL-C, higher Hgb A1c, decreasing eGFR, and increasing systolic blood pressure were significant predictors of increased hsTnI. …"

Post-marketing safety of panitumumab: a real-world pharmacovigilance study حسب Heli Wen (20459923)

"…Age and sex subgroup analyses revealed specific risks, such as polyneuropathy and gene mutation in those under 65 years of age, decreased neutrophil count and peripheral sensory neuropathy in those over 65 years of age, and febrile neutropenia in men. …"

Supplementary Material for: Evolution of growth following anti-TNF-α therapy in paediatric Crohn’s disease: data from the Swiss IBD Cohort Study حسب figshare admin karger (2628495)

"…Height velocity z-scores showed a significant increase across both genders. Factors contributing to a decreased height z-score included male sex, age 10 and below at diagnosis, a concomitant corticosteroid treatment and a top-down treatment strategy. …"

Table 1_The impact of IL-17A inhibitors on scalp and gut microbiota in psoriasis.docx حسب Wenxia Huang (12290795)

"…Regarding gut microbiota, significant differences in α-diversity richness were observed compared to healthy controls (P<0.05). …"

Table 1_Trends in the burden of urolithiasis in China: an analysis from the global burden of disease study 2021.xlsx حسب Yangyang Lin (3797422)

"…The results showed that the burden of urolithiasis was significantly higher in males than in females. Furthermore, although the burden of urolithiasis has gradually improved in both men and women over the past 30 years, the BAPC prediction model suggests that the burden of urolithiasis is likely to increase in the next 15 years in both sexes. …"

Data Sheet 1_The global, regional, and national impact of laryngeal cancer from 1990 to 2021, along with forecasts for 2050: a comprehensive analysis for the Global Burden of Disea... حسب Tingting Duan (5181482)

"…However, there are significant differences among different countries and regions. …"

Global, regional, and national trends in colorectal cancer from 2010 to 2021: an analysis of the global burden of disease study 2021 حسب Gerun Chen (21924829)

"…</p> <p></p><p>There are significant differences in the global burden of colorectal cancer across age, sex, and region.…"

Supplemental Material For Coronary Microvascular Remodeling in Pressure-Overload RV حسب Ilham Essafri (21688937)

"…Notably, resistance was significantly higher in male SHAM mice compared to females at baseline, and decreased in males but not in females post-PAB. …"

Characterization of Behaviors During Food Consumption Under Novelty and Threat Learning in Male and Female Rats (MK Thesis) حسب Rebecca Shteyn (20927324)

"…Renewal of mobility behaviors was not observed, indicating that mobility behaviors were not conditioned to the tone. There were no significant differences in freezing, mobility, or neutral behaviors based on prior novelty exposure, but these findings establish a behavioral baseline for examining how novelty-related experience may interact with threat learning and memory and reveal meaningful sex differences across both paradigms.…"

Table 1_A national population-based study of mortality and risk factors in COVID-19-hospitalized patients in Spain (2020–2021).docx حسب José-Manuel Ramos-Rincón (10428656)

"…IHM rose with age, from 0.8% in patients aged 18–39 to 31.7% in those ≥80 years (p < 0.001), but significant decreases were observed across all age groups after vaccination, especially in those ≥80 years (AOR: 0.76, 95% CI: 0.75–0.79, p < 0.001). …"

Data Sheet 1_Correlation analysis of osteoporosis and vertebral endplate defects using CT and MRI imaging: a retrospective cross-sectional study.pdf حسب Song Hao (5700608)

"…The relationships between the HU value and other data between the vertebral body defect group and the nonvertebral body defect group were compared. We found significant differences in age (70.6 ± 8.4 vs. 63.8 ± 9.5, p < 0.001), sex (male/female) (26/69 vs. 43/61, p < 0.05), BMI (23.8 ± 3.4 vs. 24.8 ± 3.4, p < 0.05), and total spine HUs (84.65 ± 35.49 vs. 124.86 ± 49.59, p < 0.001). …"

Data Sheet 1_Lack of association between genetic variations in CYP3A5 and blood pressure or hypertension risk in the UK biobank.pdf حسب Pia Leibold (21390134)

"…Linear and logistic regression models were used, adjusting for age, sex, race, antihypertensives use, smoking status, and salt intake. …"

Table 1_Unpacking the cost implications of diagnosis-related groups reform for lumbar disc herniation patients in Chinese medicine: a closer look at evidence from China.xls حسب Meng-en Chen (22274533)

"…However, significant differences were noted in sex, age, visit times, admission pathways, admission disease status, complications and comorbidities, and surgeries and operations (p < 0.05). …"

Table 2_L-shaped association between triglyceride-glucose body mass index and short-term mortality in ICU patients with sepsis-associated acute kidney injury.docx حسب Heping Xu (95297)

"…Higher TyG-BMI values were significantly associated with reduced short-term mortality rates (28, 90, and 180 days) in patients with SA-AKI; for each standard deviation increase in TyG-BMI, the risk of all-cause death decreased by 0.2% (p < 0.0001). …"

Table 1_L-shaped association between triglyceride-glucose body mass index and short-term mortality in ICU patients with sepsis-associated acute kidney injury.docx حسب Heping Xu (95297)

"…Higher TyG-BMI values were significantly associated with reduced short-term mortality rates (28, 90, and 180 days) in patients with SA-AKI; for each standard deviation increase in TyG-BMI, the risk of all-cause death decreased by 0.2% (p < 0.0001). …"

Data Sheet 1_Global, regional, and national epidemiology of otitis media in children from 1990 to 2021.docx حسب HanYu Wang (16362600)

"…Key risk factors identified include secondhand smoke, particulate matter pollution, low birth weight, and short gestation. Additionally, a significant inverse association was found between the SDI and the burden of OM, with age-standardized DALY rates decreasing markedly as SDI increased.…"

Data Sheet 1_Sleep is enhanced in aged male mice that overexpress calcium/calmodulin-dependent protein kinase IV.docx حسب Sierra P. Feeney (21466928)

"…Using 2- to 4-month-old (young adult) and 22- to 24-month-old (aged) male and female CaMKIV-overexpressing (CaMKIV-OE) mice, we observed that overexpression of CaMKIV in the forebrain decreased wakefulness and increased the amount of non-rapid eye movement (NREM) and rapid eye movement (REM) sleep in aged male mice, but not young adult male mice, in comparison to age- and sex-matched controls. …"

Supplementary file 4_Breast cancer burden in the United States (1990–2021) with a 15-year forecast: a comprehensive analysis based on the global burden of disease 2021.gif حسب Zhijian Huang (1649578)

"…</p>Results<p>BC burden in the U.S. has decreased, with reductions in age-standardized rates of prevalence, incidence, mortality, and DALYs for both sexes. …"

Data Sheet 4_Breast cancer burden in the United States (1990–2021) with a 15-year forecast: a comprehensive analysis based on the global burden of disease 2021.csv حسب Zhijian Huang (1649578)

"…</p>Results<p>BC burden in the U.S. has decreased, with reductions in age-standardized rates of prevalence, incidence, mortality, and DALYs for both sexes. …"