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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
significant shifts » significant insights (Expand Search), significant benefits (Expand Search)
shifts decrease » sizes decrease (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
significant shifts » significant insights (Expand Search), significant benefits (Expand Search)
shifts decrease » sizes decrease (Expand Search)
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Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement
Published 2025“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”
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Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement
Published 2025“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”
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245
Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement
Published 2025“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”
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Characteristics of Study Participants.
Published 2025“…We measured changes in routine HBV vaccine confidence with a previously validated Shift in Vaccine Confidence (SVC) self-report measure that was verbally administered in Lingala (local language). …”
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Regression situation of each cross-section.
Published 2025“…Furthermore, as the coarse particle content rises, the strata loss rate tends to decrease gradually. The final settlement curve, calculated using the method that considers changes in coarse particle content, is closer to the measured values. …”
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Statistical Table of Formation Loss Rate <i>V1.</i>
Published 2025“…Furthermore, as the coarse particle content rises, the strata loss rate tends to decrease gradually. The final settlement curve, calculated using the method that considers changes in coarse particle content, is closer to the measured values. …”
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Fitting Results for Each Operating Condition.
Published 2025“…Furthermore, as the coarse particle content rises, the strata loss rate tends to decrease gradually. The final settlement curve, calculated using the method that considers changes in coarse particle content, is closer to the measured values. …”
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The spatial pattern of dengue including hotspot and coldspot in Bangladesh in 2019–2023.
Published 2024Subjects: -
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The spatial (districtwide) distribution of census population of Bangladesh in 2022.
Published 2024Subjects: -
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Spectral shift of fluorophore NHS-esters.
Published 2025“…After 5 min of illumination with a 561-nm excitation laser, the fluorescence signal in the 647-nm detection channel decreased, while the signal in the 561-nm detection channel significantly increased, indicating a spectral blue-shift of the emission spectrum. …”