Showing 241 - 260 results of 896 for search '(( significant decrease decrease ) OR ( significant shifts decrease ))~', query time: 0.41s Refine Results
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    Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

    Published 2025
    “…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”
  4. 244

    Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

    Published 2025
    “…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”
  5. 245

    Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

    Published 2025
    “…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”
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    Characteristics of Study Participants. by Alix Boisson-Walsh (17847176)

    Published 2025
    “…We measured changes in routine HBV vaccine confidence with a previously validated Shift in Vaccine Confidence (SVC) self-report measure that was verbally administered in Lingala (local language). …”
  9. 249

    Regression situation of each cross-section. by Puzhen An (21169189)

    Published 2025
    “…Furthermore, as the coarse particle content rises, the strata loss rate tends to decrease gradually. The final settlement curve, calculated using the method that considers changes in coarse particle content, is closer to the measured values. …”
  10. 250

    Statistical Table of Formation Loss Rate <i>V1.</i> by Puzhen An (21169189)

    Published 2025
    “…Furthermore, as the coarse particle content rises, the strata loss rate tends to decrease gradually. The final settlement curve, calculated using the method that considers changes in coarse particle content, is closer to the measured values. …”
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    Fitting Results for Each Operating Condition. by Puzhen An (21169189)

    Published 2025
    “…Furthermore, as the coarse particle content rises, the strata loss rate tends to decrease gradually. The final settlement curve, calculated using the method that considers changes in coarse particle content, is closer to the measured values. …”
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    Spectral shift of fluorophore NHS-esters. by Hyunwoo Kim (690467)

    Published 2025
    “…After 5 min of illumination with a 561-nm excitation laser, the fluorescence signal in the 647-nm detection channel decreased, while the signal in the 561-nm detection channel significantly increased, indicating a spectral blue-shift of the emission spectrum. …”