Table 2_Gallic acid attenuates diabetic cardiomyopathy by inhibiting ferroptosis and protecting mitochondria via the TSPO/FTMT pathway.xlsx by Chenchao Zou (22768010)

“…Bioinformatics analysis identified potential target genes for GA’s cardioprotection, which were subsequently validated using pAD/TSPO (for overexpression) and pAD/FTMT-shRNA (for silencing) constructs.</p>Results<p>GA treatment decreased PTGS2, lactate dehydrogenase, malondialdehyde, ferrous iron, ROS, and oxidized glutathione disulfide (GSSG) levels and increased cell viability, glutathione (GSH) levels, the GSH/GSSG ratio, and GPX4 protein levels in the injury models. …”

Image 3_Low-frequency electroacupuncture attenuates methamphetamine-induced depressive-like behaviors and cognitive impairment via modulating neuroinflammation.tif by Jingyi Zhang (741111)

“…EA may represent a promising non-pharmacological strategy for the treatment of METH-associated neuropsychiatric disorders.…”

Data Sheet 1_Cordycepin attenuates NLRP3/Caspase-1/GSDMD-mediated LPS-induced macrophage pyroptosis.pdf by Zige Liu (20724752)

“…The results demonstrated that cordycepin exhibits strong binding affinity for NLRP3, Caspase-1, and GSDMD. Cordycepin pre-treatment significantly reduced ROS levels and XO activity, inhibited the expression of NLRP3, cleaved-Caspase-1, and cleaved-GSDMD, and decreased pyroptosis-associated inflammatory cytokines IL-1β and IL-18, along with Caspase-1 activity. …”

Effect of CBZ pretreatment on HSR-induced histological damage in the lungs of rats with acute lung injury. by Yaqiang Li (7423778)

“…However, these histopathological changes were significantly ameliorated after treatment with CBZ. DMSO had no influence on histological damage, while the CBZ/CQ/HSR group showed a severe damage compared with the CBZ/HSR group. …”

Image 1_Low-frequency electroacupuncture attenuates methamphetamine-induced depressive-like behaviors and cognitive impairment via modulating neuroinflammation.tif by Jingyi Zhang (741111)

“…EA may represent a promising non-pharmacological strategy for the treatment of METH-associated neuropsychiatric disorders.…”

DataSheet1_Lats-IN-1 protects cardiac function and promotes regeneration after myocardial infarction by targeting the hippo pathway.PDF by Hua Shen (54290)

“…Additionally, Lats-IN-1 decreased infarct size and apoptosis rates while promoting cardiomyocyte proliferation. …”

Data Sheet 1_Dual upregulation of miRNA-143 and miRNA-506 in non-small cell lung cancer inhibits proliferation, motility, migration, and tumor growth.pdf by Archana Shrestha (3641959)

“…Our study highlights the advantages of investigating combinatorial miRs for cancer treatment, particularly miR-143/506 against LC.</p>…”

Data Sheet 1_Regulation of SLC7A11 by LncRNA GPRC5D-AS1 mediates ferroptosis in skeletal muscle: Mechanistic exploration of sarcopenia.pdf by Wei Gong (112494)

“…In the sarcopenia group, both GPRC5D-AS1 and SLC7A11 expression levels decreased significantly, along with SLC7A11 protein translation. …”

Data Sheet 1_GPER1 signaling restricts macrophage proliferation and accumulation in human hepatocellular carcinoma.pdf by Yanyan Yang (412382)

“…The expression of G protein–coupled estrogen receptor 1 (GPER1), a non-classical estrogen receptor, was significantly decreased in proliferating macrophages, and was inversely correlated with macrophage proliferation in HCC tumors. …”

Table 1_Therapeutic potential and mechanistic insights of silibinin targeting cancer-associated fibroblasts in colorectal cancer.xlsx by Shenglan He (7641308)

“…Consistently, in vitro experiments demonstrated that SB significantly decreased both protein and mRNA levels of α-SMA and POSTN in fibroblasts (colonic myofibroblast CCD-18Co cell lines.) co-cultured with CRC cell lines (human colorectal adenocarcinoma SW480 and RKO cell lines). …”

Supplementary file 1_Regulation of SLC7A11 by LncRNA GPRC5D-AS1 mediates ferroptosis in skeletal muscle: Mechanistic exploration of sarcopenia.pdf by Wei Gong (112494)

“…In the sarcopenia group, both GPRC5D-AS1 and SLC7A11 expression levels decreased significantly, along with SLC7A11 protein translation. …”

Supplementary file 1_Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease.docx by Demos Kynigopoulos (12420457)

“…Gliclazide reduced neuroinflammation and partially preserved glial and neuronal markers. Both treatments decreased amyloid burden and modulated adipokine levels, with Alirocumab elevating leptin and omentin in brain and serum. …”

Data Sheet 4_Sirtuin 6 mediates the therapeutic effect of endometrial regenerative cell-derived exosomes in alleviation of acute transplant rejection by weakening c-myc-dependent g... by Tong Liu (107783)

“…Furthermore, in the recipient mice, ERC-Exo treatment markedly increased the differentiation of regulatory T cells (Tregs) while significantly decreasing that of Th1 and Th17 cells. …”

Data Sheet 5_Sirtuin 6 mediates the therapeutic effect of endometrial regenerative cell-derived exosomes in alleviation of acute transplant rejection by weakening c-myc-dependent g... by Tong Liu (107783)

“…Furthermore, in the recipient mice, ERC-Exo treatment markedly increased the differentiation of regulatory T cells (Tregs) while significantly decreasing that of Th1 and Th17 cells. …”

Data Sheet 1_Sirtuin 6 mediates the therapeutic effect of endometrial regenerative cell-derived exosomes in alleviation of acute transplant rejection by weakening c-myc-dependent g... by Tong Liu (107783)

“…Furthermore, in the recipient mice, ERC-Exo treatment markedly increased the differentiation of regulatory T cells (Tregs) while significantly decreasing that of Th1 and Th17 cells. …”

Data Sheet 3_Sirtuin 6 mediates the therapeutic effect of endometrial regenerative cell-derived exosomes in alleviation of acute transplant rejection by weakening c-myc-dependent g... by Tong Liu (107783)

“…Furthermore, in the recipient mice, ERC-Exo treatment markedly increased the differentiation of regulatory T cells (Tregs) while significantly decreasing that of Th1 and Th17 cells. …”

Data Sheet 2_Sirtuin 6 mediates the therapeutic effect of endometrial regenerative cell-derived exosomes in alleviation of acute transplant rejection by weakening c-myc-dependent g... by Tong Liu (107783)

“…Furthermore, in the recipient mice, ERC-Exo treatment markedly increased the differentiation of regulatory T cells (Tregs) while significantly decreasing that of Th1 and Th17 cells. …”

Supplementary file 1_Sirtuin 6 mediates the therapeutic effect of endometrial regenerative cell-derived exosomes in alleviation of acute transplant rejection by weakening c-myc-dep... by Tong Liu (107783)

“…Furthermore, in the recipient mice, ERC-Exo treatment markedly increased the differentiation of regulatory T cells (Tregs) while significantly decreasing that of Th1 and Th17 cells. …”

<b>Targeted Inhibition of Tumor-Intrinsic SIRPα Improve anti-PD-1 Resistance by Enhancing T Cell Immunity and Inhibits</b><b> Tumor </b><b>Proliferation in Esophageal Cancer: Thera... by Xi-Yang Tang (13184496)

“…Apoptosis of PBMC and Jurkat T cell were significantly decreased cocultured with SIRPA knockdown esophageal cells. …”

Protective role of <i>N</i>-acetyl-l-tryptophan against hepatic ischemia-reperfusion injury via the RIP2/caspase-1/IL-1β signaling pathway by Jianxin Wang (35827)

“…Similarly, IL-1β activity and caspase-1 activity were significantly decreased in the H₂O₂ group when compared with the controls, after l-NAT intervention.…”