Table 4_Integrative RNA-seq and CLIP-seq analysis reveals hnRNP-F regulation of TNFα/NFκB signaling in high-glucose conditions.xlsx by Lan Wang (85307)

“…We also downloaded the CLIP-seq data of hnRNP-F in human 293T cells from the Gene Expression Omnibus (GEO) database. …”

DataSheet1_Genome-wide association analysis and genomic prediction of salt tolerance trait in soybean germplasm.xlsx by Rongqing Xu (9504492)

“…Employing four distinct models—we performed a genome-wide association study (GWAS) using four models, including MLM, MLMM, FarmCPU, and BLINK in GAPIT 3, we conducted a Genome-Wide Association Study (GWAS) to identify single nucleotide polymorphism (SNP) associated with salt tolerance in soybean. …”

Data Sheet 1_Unveiling the effects of land use and intra-seasonal variation on bee and plant diversity and their ecological interactions in vegetation surrounding coffee plantation... by Quebin Bosbely Casiá-Ajché (14234267)

“…<p>Land use, local management, and seasonal variation significantly impact the ecological dynamics of bee–plant communities and their ecological interactions. …”

Effect of amikacin-humic acid combination on <i>Acinetobacter baumannii</i> biofilm: an <i>in vitro</i> and <i>in silico</i> study by Seetha Lakshmi Rajangam (19921021)

“…The images observed via Scanning Electron Microscope (SEM) showed a significant decrease in the biofilm matrix. Confocal Laser Scanning Microscope (CLSM) confirmed a reduction of the Z value of its three-dimensional structure. …”

Table1_Leishmania major surface components and DKK1 signalling via LRP6 promote migration and longevity of neutrophils in the infection site.docx by Olivia C. Ihedioha (19925886)

“…Relative to infected BALB/c mice, a significant reduction in parasite load was observed in both LRP6^NKO and LRP6^NKO DKK1^PKO infected mice. …”

Data Sheet 1_Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway.pdf by figshare admin frontiersin (4545187)

“…Combining network pharmacology prediction analysis with our validation data from animal models and colonic organoids, we demonstrated that Cyn significantly inhibits IEC apoptosis, as indicated by a decrease in the proportion of TUNEL-positive cells and changes in apoptosis-related protein levels. …”

<b>The role of the </b><b>LncRNA </b><b>XIST/miR-15a-5p/ MN1</b><b>signaling </b><b>axis in gender disparities in bladder cancer prognosis</b> by Qingshui Wang (17151220)

“…Increased XIST mRNA levels were significantly associated with dismal overall survival in female BC patients. …”

Table 1_The association between a dietary index for the gut microbiota and frailty in older adults: emphasising the mediating role of inflammatory indicators.docx by Huangyi Yin (18593848)

“…Background<p>The dietary index for the gut microbiota (DI-GM) is a novel indicator of gut microbiome health, and its association with frailty remains unknown.</p>Methods<p>We recruited participants from the 2007–2020 National Health and Nutrition Examination Survey (NHANES). …”

Supplementary file 1_Dynamic reconfiguration and transition of whole-brain networks in patients with MELAS revealed by a hidden Markov model.docx by Qingyun Yu (18837625)

“…Based on HMM, fractional occupancies in states 5 and 6 for MELAS were significantly decreased (p < 0.001), but fractional occupancies in states 2, 3, 4, 7, 8, 9, 10, and 11 were significantly increased (p < 0.05), compared to HCs. …”

Data Sheet 1_Treatment of bacterial biothreat agents with a novel purified bioactive lactoferrin affects both growth and biofilm formation.docx by Christian Xander (9120108)

“…Here, we show that Lactea Lf can significantly inhibit biofilm and decrease the overall growth in a dose dependent manner for all Burkholderia species tested. …”

Table 1_Effects of exogenous insulin supplementation on lipid metabolism in peripartum obese dairy cows.docx by Yuanyin Guo (19207081)

“…We selected 181 periparturient multiparous obese dairy cows for the study. …”

S-nitrosoglutathione inhibits pyroptosis of kidney tubular epithelial cells in sepsis via the SIRT3/SOD2/mtROS signaling pathway by Heng Fan (814041)

“…However, after SNG pretreatment, the levels of IL-1β, IL-6, IL-18, TNF-α, MDA and mtROS were all significantly decreased, the expression of SIRT3 and SOD2 proteins were increased, NLRP3, GSDMD, Caspase-1 proteins expression and the number of KTECs apoptotic cells were decreased.…”

Data_Sheet_2_Long-Term Overconsumption of Sugar Starting at Adolescence Produces Persistent Hyperactivity and Neurocognitive Deficits in Adulthood.PDF by Kate Beecher (6688340)

“…Using a well-validated mouse model of sugar consumption, we found that long-term sugar consumption, at a level that significantly augments weight gain, elicits an abnormal hyperlocomotor response to novelty and alters both episodic and spatial memory. …”

Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation by Huang-Ju Tu (630766)

“…In this study, we utilised structure-based virtual screening (SBVS) from NCI library to discover novel DYRK1A inhibitors. …”

Data_Sheet_1_Long-Term Overconsumption of Sugar Starting at Adolescence Produces Persistent Hyperactivity and Neurocognitive Deficits in Adulthood.PDF by Kate Beecher (6688340)

“…Using a well-validated mouse model of sugar consumption, we found that long-term sugar consumption, at a level that significantly augments weight gain, elicits an abnormal hyperlocomotor response to novelty and alters both episodic and spatial memory. …”

Predicting the potential distribution of <i>Arisaema heterophyllum</i> in China under current and future climate change based on ArcGIS and MaxEnt model by Jing Xu (15337)

“…<p>Climate change significantly affects the distribution of medicinal plants, necessitating accurate models to predict future shifts in their habitats. …”

OMT by Jingmin Ou (19669426)

“…OMT was found to significantly increase the apoptosis rate of endothelial cells (ECs) treated with oxidised low-density lipoprotein (ox-LDL), as measured by caspase-3 activity assay and flow cytometry. qRT-PCR results showed that OMT treatment decreased the expression of miR-199a-5p in ECs.Transfection of miR-199a-5p mimics enhanced the apoptotic effect, whereas miR-199a-5p inhibitors attenuated apoptosis, suggesting that miR-199a-5p has a key regulatory role in EC apoptosis. …”

Data Sheet 1_A ROS-responsive, aptamer-targeted graphene oxide nanocomposite for site-specific glutathione release in cerebral ischemia-reperfusion injury.docx by Meiying Li (6051287)

“…In vitro, GO@GSH-FA significantly restored viability in oxygen-glucose-deprived SH-SY5Y cells (from 31% up to near control levels), reduced inflammatory cytokines, and lowered intracellular ROS. …”

Table3_Multi-omics analysis provides insights into the mechanism underlying fruit color formation in Capsicum.docx by Zhao Song (7135202)

“…In this study, the light-yellow color observed in immature CSJ009 fruits compared to CSJ010 could be attributed to decreased chlorophyll and carotenoid pigments. Through integrated analysis of the transcriptome and metabolome of CSJ009 and CSJ010, we identified 23,930 differentially expressed genes (DEGs) and 345 differentially accumulated metabolites (DAMs). …”

Table2_Multi-omics analysis provides insights into the mechanism underlying fruit color formation in Capsicum.xlsx by Zhao Song (7135202)

“…In this study, the light-yellow color observed in immature CSJ009 fruits compared to CSJ010 could be attributed to decreased chlorophyll and carotenoid pigments. Through integrated analysis of the transcriptome and metabolome of CSJ009 and CSJ010, we identified 23,930 differentially expressed genes (DEGs) and 345 differentially accumulated metabolites (DAMs). …”