Image 5_Wip1 inhibitor CCT007093 alleviates immune exhaustion of lymphocytes via p65 NF-κB and YY1 in chronic hepatitis B virus infection in mice.tif by Yu-Syuan You (21288113)

“…</p>Methods<p>We focused on CCT007093, a Wip1 inhibitor, screened for its distinctive capacity to simultaneously decrease PD-1 and FcγRIIB expression in B cells.…”

Image 3_Wip1 inhibitor CCT007093 alleviates immune exhaustion of lymphocytes via p65 NF-κB and YY1 in chronic hepatitis B virus infection in mice.tif by Yu-Syuan You (21288113)

“…</p>Methods<p>We focused on CCT007093, a Wip1 inhibitor, screened for its distinctive capacity to simultaneously decrease PD-1 and FcγRIIB expression in B cells.…”

Image 9_Wip1 inhibitor CCT007093 alleviates immune exhaustion of lymphocytes via p65 NF-κB and YY1 in chronic hepatitis B virus infection in mice.tif by Yu-Syuan You (21288113)

“…</p>Methods<p>We focused on CCT007093, a Wip1 inhibitor, screened for its distinctive capacity to simultaneously decrease PD-1 and FcγRIIB expression in B cells.…”

Proportion of various unloading amplitudes. by Yanxu Liang (22227024)

“…The study shows that: (1) With the increase of unloading amplitude, there is an increase in the number of nascent cracks and a tendency to expand, which is caused by shear extension cracks; with the increase of unloading amplitude, there is a tendency for the microporosity to shift to the mesoporosity, and the mesoporosity has a tendency to shift to the macroporosity, and there is a decrease in the number of micropores as a whole, which indicates that there is almost no new pore sprouting. (2) When the unloading amplitude is less than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen increase slowly; when the unloading amplitude is more than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen have a significant tendency to increase. (3) With the increase of unloading amplitude, the shale shear strength limit value decreases more slowly, the modulus of elasticity and shear strength also show a similar pattern of change, and the same way to derive the rock Poisson’s ratio does not change much.…”

Mineral fractions of rock samples. by Yanxu Liang (22227024)

“…The study shows that: (1) With the increase of unloading amplitude, there is an increase in the number of nascent cracks and a tendency to expand, which is caused by shear extension cracks; with the increase of unloading amplitude, there is a tendency for the microporosity to shift to the mesoporosity, and the mesoporosity has a tendency to shift to the macroporosity, and there is a decrease in the number of micropores as a whole, which indicates that there is almost no new pore sprouting. (2) When the unloading amplitude is less than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen increase slowly; when the unloading amplitude is more than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen have a significant tendency to increase. (3) With the increase of unloading amplitude, the shale shear strength limit value decreases more slowly, the modulus of elasticity and shear strength also show a similar pattern of change, and the same way to derive the rock Poisson’s ratio does not change much.…”

Porosity and void ratio of each binary image. by Yanxu Liang (22227024)

“…The study shows that: (1) With the increase of unloading amplitude, there is an increase in the number of nascent cracks and a tendency to expand, which is caused by shear extension cracks; with the increase of unloading amplitude, there is a tendency for the microporosity to shift to the mesoporosity, and the mesoporosity has a tendency to shift to the macroporosity, and there is a decrease in the number of micropores as a whole, which indicates that there is almost no new pore sprouting. (2) When the unloading amplitude is less than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen increase slowly; when the unloading amplitude is more than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen have a significant tendency to increase. (3) With the increase of unloading amplitude, the shale shear strength limit value decreases more slowly, the modulus of elasticity and shear strength also show a similar pattern of change, and the same way to derive the rock Poisson’s ratio does not change much.…”

Data Sheet 1_Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity.docx by Stefanie Hoffmann (3756733)

“…Overall, from the 23 tested compounds, 15 showed the expected outcome, i.e., the compound led to a decrease of the TEER for the positive control compounds, or the TEER value remained stable after treatment with non-GI-toxic compounds.…”

Images of SEM after binary processing. by Yanxu Liang (22227024)

“…The study shows that: (1) With the increase of unloading amplitude, there is an increase in the number of nascent cracks and a tendency to expand, which is caused by shear extension cracks; with the increase of unloading amplitude, there is a tendency for the microporosity to shift to the mesoporosity, and the mesoporosity has a tendency to shift to the macroporosity, and there is a decrease in the number of micropores as a whole, which indicates that there is almost no new pore sprouting. (2) When the unloading amplitude is less than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen increase slowly; when the unloading amplitude is more than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen have a significant tendency to increase. (3) With the increase of unloading amplitude, the shale shear strength limit value decreases more slowly, the modulus of elasticity and shear strength also show a similar pattern of change, and the same way to derive the rock Poisson’s ratio does not change much.…”

Microcosmic pores parameters calculation results. by Yanxu Liang (22227024)

“…The study shows that: (1) With the increase of unloading amplitude, there is an increase in the number of nascent cracks and a tendency to expand, which is caused by shear extension cracks; with the increase of unloading amplitude, there is a tendency for the microporosity to shift to the mesoporosity, and the mesoporosity has a tendency to shift to the macroporosity, and there is a decrease in the number of micropores as a whole, which indicates that there is almost no new pore sprouting. (2) When the unloading amplitude is less than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen increase slowly; when the unloading amplitude is more than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen have a significant tendency to increase. (3) With the increase of unloading amplitude, the shale shear strength limit value decreases more slowly, the modulus of elasticity and shear strength also show a similar pattern of change, and the same way to derive the rock Poisson’s ratio does not change much.…”

Percentage of different <i><i>d</i></i>_max/<i><i>d</i></i>_min. by Yanxu Liang (22227024)

“…The study shows that: (1) With the increase of unloading amplitude, there is an increase in the number of nascent cracks and a tendency to expand, which is caused by shear extension cracks; with the increase of unloading amplitude, there is a tendency for the microporosity to shift to the mesoporosity, and the mesoporosity has a tendency to shift to the macroporosity, and there is a decrease in the number of micropores as a whole, which indicates that there is almost no new pore sprouting. (2) When the unloading amplitude is less than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen increase slowly; when the unloading amplitude is more than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen have a significant tendency to increase. (3) With the increase of unloading amplitude, the shale shear strength limit value decreases more slowly, the modulus of elasticity and shear strength also show a similar pattern of change, and the same way to derive the rock Poisson’s ratio does not change much.…”

Transcriptomics insight into occupational exposure to engineered nanoparticles by Zuzana Simova (19368296)

“…</p> <p>Following PM0.1 exposure, a significant decrease in the expression of <i>DDIT4</i> and <i>FKBP5</i>, genes involved in the stress response, was detected in exposed workers. …”

Schematic diagram of test stress unloading path. by Yanxu Liang (22227024)

“…The study shows that: (1) With the increase of unloading amplitude, there is an increase in the number of nascent cracks and a tendency to expand, which is caused by shear extension cracks; with the increase of unloading amplitude, there is a tendency for the microporosity to shift to the mesoporosity, and the mesoporosity has a tendency to shift to the macroporosity, and there is a decrease in the number of micropores as a whole, which indicates that there is almost no new pore sprouting. (2) When the unloading amplitude is less than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen increase slowly; when the unloading amplitude is more than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen have a significant tendency to increase. (3) With the increase of unloading amplitude, the shale shear strength limit value decreases more slowly, the modulus of elasticity and shear strength also show a similar pattern of change, and the same way to derive the rock Poisson’s ratio does not change much.…”

<i>T</i>₂ spectra distribution of samples. by Yanxu Liang (22227024)

“…The study shows that: (1) With the increase of unloading amplitude, there is an increase in the number of nascent cracks and a tendency to expand, which is caused by shear extension cracks; with the increase of unloading amplitude, there is a tendency for the microporosity to shift to the mesoporosity, and the mesoporosity has a tendency to shift to the macroporosity, and there is a decrease in the number of micropores as a whole, which indicates that there is almost no new pore sprouting. (2) When the unloading amplitude is less than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen increase slowly; when the unloading amplitude is more than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen have a significant tendency to increase. (3) With the increase of unloading amplitude, the shale shear strength limit value decreases more slowly, the modulus of elasticity and shear strength also show a similar pattern of change, and the same way to derive the rock Poisson’s ratio does not change much.…”

Data of Fig 5C. by Xianyu Piao (145967)

“…Among these five rSjCLs, only the immunization with rSjCL1 conferred partial protection to the mice against <i>S. japonicum</i> infection, resulting in a reduction in worm burden by 34.9% ~ 38.0% and a decrease of egg burden by 46.2% ~ 48.3%. …”

Data Sheet 1_Spatiotemporal analysis of the burden of lower respiratory infections in the older adult population due to air pollution: trends from 1990 to 2021 and predictions for... by Zheng Lei (2250328)

“…Background<p>Lower respiratory infections (LRI), caused by various pathogens, have significant impacts on global health. Air pollution is a major environmental factor in the development of LRI, and with ongoing urbanization and industrialization, it has become a critical public health concern. …”

Table 1_2,4-Di-tert-butylphenol from Endophytic Fungi Fusarium oxysporum attenuates the growth of multidrug-resistant pathogens.docx by Ranjitha Dhevi V. Sundar (21515288)

“…In a cytotoxicity assay, it is more active against the cell line with a decrease in cell viability of 50.12% at 1,000 μg/mL concentration. …”

Data Sheet 1_Virological response and predictive factors for antiviral treatment in chronic HBV-related liver disease with low ALT and high HBV DNA.docx by Lei Ma (221178)

“…Objective<p>To investigate virological response and predictive factors for antiviral treatment in chronic HBV patients with low ALT and high HBV DNA.</p>Methods<p>A retrospective study grouped chronic HBV patients by baseline ALT: ALT > 80 U/L (significantly elevated group, SAG), 40-80 U/L (mildly elevated group, MAG), and ≤ 40 U/L (normal group, NG). …”

Thermogenetic activation in male flies. by Joseph D. Jones (13883524)

“…<b>(D)</b> Box plots of nighttime sleep bout duration for flies presented in A. Two-way repeated measures ANOVA followed by Sidak’s multiple comparisons revealed that control and most FBS lines show a significant decrease in nighttime sleep bout duration between 22 °C and 31 °C, and 4 sleep-promoting FBS lines show no difference between 22 and 31 °C (FBS42, FBS53, FBS81, and FBS84) while FBS45 and FBS68 show an increase in nighttime sleep bout duration at 31 °C. …”

Table_1_Spatiotemporal variation in grain production performance and efficiency of the cultivated landscapes in Upper Blue Nile Basin of Ethiopia: the impact of residual moisture-b... by Tibebu Kassawmar (5120267)

“…The results show that only 39% of the basin is currently cultivated, although a significant cropland expansion (10%) was recorded between 1985 and 2020. …”

Image_3_Spatiotemporal variation in grain production performance and efficiency of the cultivated landscapes in Upper Blue Nile Basin of Ethiopia: the impact of residual moisture-b... by Tibebu Kassawmar (5120267)

“…The results show that only 39% of the basin is currently cultivated, although a significant cropland expansion (10%) was recorded between 1985 and 2020. …”