Table 6_The benefits and risks of adding PD-1/PD-L1 inhibitors to chemotherapy for stage IIIb-IV non-small-cell lung cancer: an updated meta-analysis based on phase 3 randomized co... by Yun Xu (139234)

“…The most common AEs in the PC group were blood toxicity related AEs (anemia, neutrophil count decreased, etc).</p>Conclusion<p>The PC therapy continues to provide a substantial survival benefit for patients with stage IIIb-IV NSCLC. …”

Table3_Overexpression of endothelial S1pr2 promotes blood–brain barrier disruption via JNK/c-Jun/MMP-9 pathway after traumatic brain injury in both in vivo and in vitro models.DOCX... by Hongbo Cheng (2848235)

“…</p>Results<p>The expression of S1pr2 significantly increased following TBI in mice. Pharmacological inhibition of S1pr2 alleviated secondary injury with reduced lesion volume, ROS generation, cerebral oedema, neurological deficits, and neuronal apoptosis; BBB disruption was also mitigated, accompanied by reduced degradation of tight junction proteins and decreased induction of matrix metalloproteinases-9 (MMP-9) post-TBI. …”

Image 3_Prediction of major adverse cardiovascular events following ST-segment elevation myocardial infarction using cardiac obesity marker—epicardial adipose tissue mass index: a... by Zeyan Liu (3748747)

“…Background<p>Although reperfusion therapy has led to improvements in the acute phase of ST-segment elevation myocardial infarction (STEMI), the incidence of major adverse cardiovascular events (MACE) following STEMI has not significantly decreased. The accumulation of epicardial adipose tissue (EAT) may be associated with poorer STEMI prognosis and could serve as a potential prognostic marker. …”

Table 1_Pingwei Powder alleviates high-fat diet-induced colonic inflammation by modulating microbial metabolites SCFAs.xlsx by Tangjuan Liu (2634649)

“…Experimental validation showed that PWP significantly downregulated the levels of PI3K, pAKT/AKT, and pmTOR/mTOR in colonic tissue, thereby enhancing autophagy in colonic epithelial cells, as evidenced by decreased levels of P62 and increased LC3B-II/LC3B-I ratios. …”

Table 3_The benefits and risks of adding PD-1/PD-L1 inhibitors to chemotherapy for stage IIIb-IV non-small-cell lung cancer: an updated meta-analysis based on phase 3 randomized co... by Yun Xu (139234)

“…The most common AEs in the PC group were blood toxicity related AEs (anemia, neutrophil count decreased, etc).</p>Conclusion<p>The PC therapy continues to provide a substantial survival benefit for patients with stage IIIb-IV NSCLC. …”

Data Sheet 1_Profile and risk factors of blood donors who experienced adverse reactions: a cross-sectional study on donor hemovigilance data reported to the national network from 2... by Junhong Yang (7807046)

“…Finally, donors from outdoor blood collection sites (0.590%) and groups (1.073%) were at a significantly higher risk of syncope compared to those from indoor blood donation sites (0.438%) and individual donors (0.174%).…”

Data Sheet 3_Polygonatum sibiricum polysaccharides enhance pancreatic β-cell function in diabetic zebrafish by mitigating mitochondrial oxidative damage via the AMPK-SIRT1 pathway.... by Fan Lin (625737)

“…</p>Results<p>Polygonatum sibiricum polysaccharides significantly improved zebrafish swimming behavior, reduced blood glucose and fructosamine levels, and enhanced ATP production (p < 0.01). …”

Image 6_The benefits and risks of adding PD-1/PD-L1 inhibitors to chemotherapy for stage IIIb-IV non-small-cell lung cancer: an updated meta-analysis based on phase 3 randomized co... by Yun Xu (139234)

“…The most common AEs in the PC group were blood toxicity related AEs (anemia, neutrophil count decreased, etc).</p>Conclusion<p>The PC therapy continues to provide a substantial survival benefit for patients with stage IIIb-IV NSCLC. …”

Table 7_Polygonatum sibiricum polysaccharides enhance pancreatic β-cell function in diabetic zebrafish by mitigating mitochondrial oxidative damage via the AMPK-SIRT1 pathway.xlsx by Fan Lin (625737)

“…</p>Results<p>Polygonatum sibiricum polysaccharides significantly improved zebrafish swimming behavior, reduced blood glucose and fructosamine levels, and enhanced ATP production (p < 0.01). …”

Dataset. by Wanjun Zhang (496858)

“…The results demonstrate that the self-correcting fuzzy PID control significantly optimizes key performance metrics: overshoot (reduced by 21.3%), settling time (shortened by 34.7%), and steady-rate error (decreased by 18.9%), outperforming both traditional PID and fuzzy PID methods in concentration and pH regulation. …”

Image 3_The benefits and risks of adding PD-1/PD-L1 inhibitors to chemotherapy for stage IIIb-IV non-small-cell lung cancer: an updated meta-analysis based on phase 3 randomized co... by Yun Xu (139234)

“…The most common AEs in the PC group were blood toxicity related AEs (anemia, neutrophil count decreased, etc).</p>Conclusion<p>The PC therapy continues to provide a substantial survival benefit for patients with stage IIIb-IV NSCLC. …”

Image 3_Prevention of chemotherapy drug-mediated human hair follicle damage: combined use of cooling with antioxidant suppresses oxidative stress and prevents matrix keratinocyte c... by Khalidah Ibraheem (9525220)

“…</p>Results<p>Chemotherapy agents reduced keratinocyte viability at 37°C by ∼65%–70%, induced HF dystrophy evident by decreased proliferation (9% Ki-67+ cells), increased apoptosis (23% TUNEL+ cells), and reduced anagen (∼10%) and pigmentation. …”

Figure 1 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia by Sydney A. Skupa (18597728)

“…Asterisks denote the significance between WT B6 and Eμ-TCL1 mice at each time point. …”

Dupilumab improves sense of smell and clinical outcomes in patients with severe chronic rhinosinusitis with nasal polyps with anosmia by Andrew P. Lane (20367704)

“…<p>Loss of sense of smell is a cardinal symptom of chronic rhinosinusitis with nasal polyps (CRSwNP) and significantly impacts health-related quality-of-life. …”

Additional file 1 of MDM2-amplified esophageal adenocarcinomas exhibit an activated metabolic and immunosuppressive phenotype with multiple potential therapeutic targets by Karl Knipper (15016346)

“…Volcano plot of all detected proteins comparing the proteome of neoadjuvantly treated MDM2-amplified and non-amplified tumors. Grey: not significantly different expressed, blue: significantly decreased expression in neoadjuvantly treated MDM2-amplified tumors, red: significantly increased expression in neoadjuvantly treated MDM2-amplified tumors. …”

H2AK119ub is bidirectionally dynamic within cis-regulatory elements during neurodevelopment. by Aditya Parmar (22331873)

“…<b>(B)</b> Volcano plot depicting H2AK119ub abundance, as detected in normalized CUT&RUN data from early and late cerebellum, within SEACR-defined consensus peak regions. The significance threshold was a false-discovery rate <0.05, as defined by DiffBind [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011843#pgen.1011843.ref065" target="_blank">65</a>] (n = 4). …”

Table2_Causal relationship between plasma lipidome and four types of pancreatitis: a bidirectional Mendelian randomization study.xlsx by Runzhou Ma (19758996)

“…Furthermore, genetically predicted increased LPC (20:4) (OR = 0.862, 95%CI = 0.796-0.934, P = 3.00 × 10^-4, PFDR = 0.027) and SM (34:2;O2) (OR = 0.753, 95%CI = 0.659-0.860, P = 2.97 × 10^-5, PFDR = 0.005) levels were associated with decreased risk of ACP.</p>Conclusions<p>Our findings provide evidence of causal associations between the specific types of lipidome and pancreatitis, offering new insights into future clinical research.…”

Table4_Causal relationship between plasma lipidome and four types of pancreatitis: a bidirectional Mendelian randomization study.xlsx by Runzhou Ma (19758996)

“…Furthermore, genetically predicted increased LPC (20:4) (OR = 0.862, 95%CI = 0.796-0.934, P = 3.00 × 10^-4, PFDR = 0.027) and SM (34:2;O2) (OR = 0.753, 95%CI = 0.659-0.860, P = 2.97 × 10^-5, PFDR = 0.005) levels were associated with decreased risk of ACP.</p>Conclusions<p>Our findings provide evidence of causal associations between the specific types of lipidome and pancreatitis, offering new insights into future clinical research.…”

Table1_Causal relationship between plasma lipidome and four types of pancreatitis: a bidirectional Mendelian randomization study.xlsx by Runzhou Ma (19758996)

“…Furthermore, genetically predicted increased LPC (20:4) (OR = 0.862, 95%CI = 0.796-0.934, P = 3.00 × 10^-4, PFDR = 0.027) and SM (34:2;O2) (OR = 0.753, 95%CI = 0.659-0.860, P = 2.97 × 10^-5, PFDR = 0.005) levels were associated with decreased risk of ACP.</p>Conclusions<p>Our findings provide evidence of causal associations between the specific types of lipidome and pancreatitis, offering new insights into future clinical research.…”

DataSheet1_Causal relationship between plasma lipidome and four types of pancreatitis: a bidirectional Mendelian randomization study.pdf by Runzhou Ma (19758996)

“…Furthermore, genetically predicted increased LPC (20:4) (OR = 0.862, 95%CI = 0.796-0.934, P = 3.00 × 10^-4, PFDR = 0.027) and SM (34:2;O2) (OR = 0.753, 95%CI = 0.659-0.860, P = 2.97 × 10^-5, PFDR = 0.005) levels were associated with decreased risk of ACP.</p>Conclusions<p>Our findings provide evidence of causal associations between the specific types of lipidome and pancreatitis, offering new insights into future clinical research.…”